The relationship between red-cell distribution width and abnormal left ventricle geometric patterns in patients with untreated essential hypertension

Abstract

Abnormal left ventricle (LV) geometric patterns are associated with an increased risk of vascular complications of hypertension (HT). The association between red-cell distribution width (RDW) and HT has been recently investigated; however, the relationship between abnormal LV geometric patterns and RDW has not been studied before. The aim of this study was to investigate the relationship between RDW and abnormal LV geometric patterns in patients with untreated essential HT. Measurements were obtained from 139 patients with untreated essential HT (mean age=51.3±16.3 years). Four different geometric patterns (NG, normal geometry; CR, concentric remodeling; EH, eccentric hypertrophy; CH, concentric hypertrophy) were determined according to the LV mass index (LVMI) and relative wall thickness (RWT). RDW, lipid parameters and other biochemical markers were measured in all patients. While the highest RDW values were detected in the CH group (P<0.05, for all), it was similar among the NG, CR and EH groups (P>0.05, for all). RDW was associated with age, LVMI and LV geometry in bivariate analysis (P<0.05, for all). In a receiver operating characteristic (ROC) curve analysis, a level of RDW>14.5 predicted CH with 81% sensitivity and 59% specificity. Age (beta=0.309, P=0.001), LV geometry type (beta=0.228, P=0.01) and RWT (beta=-0.278; P=0.25) were independent predictors of high RDW in multiple linear regression analysis. In conclusion, the highest RDW values were observed in the CH group in the untreated essential HT patients. RDW seems to be a useful tool for the prediction of end-organ damage in patients with untreated essential HT.

Red Cell Distribution Width and Inappropriateness of Left Ventricular Mass in Patients with Untreated Essential Hypertension

“…This study also indicates an association between RDW and LVH and affirms the importance of this index in the full evaluation of hypertensive patients. We noticed that a similar study conducted by Kilicaslan et al had been published in the Hypertension Research [ 25 ]. In this study four different geometric patterns (Normal geometry, concentric remodeling, eccentric hypertrophy, concentric hypertrophy) were determined according the LVMI, and they found that LV geometry type were independent associated with high RDW.…”

Red cell distribution width and end-organ damage in patients with systo-diastolic hypertension

“…Kilicaslan et al . recently demonstrated that RDW values were associated with ventricular geometrical patterns [ 23 ] in untreated hypertensive patients.…”

Red Cell Distribution Width as an Independent Predictor of Long-Term Mortality in Hip Fracture Patients: A Prospective Cohort Study

“…Red blood cell distribution width (RDW), which is a readily available parameter in complete blood cell counts (CBC), has been conventionally used for the evaluation of heterogeneity of circulating erythrocytes and differential diagnosis of anemia . However, recent studies have found that increased RDW also shows promising predictive value for many diseases with high mortality, such as hypertension, myocardial infarction, coronary heart disease, heart failure, sepsis, and acute pancreatitis . Although the underlying biological and metabolic mechanism of increased RDW has not been validated, the association between higher RDW and higher mortality risk in many diseases indicates that the clinical significance of RDW should be broadened.…”