The Relationship Between Red Cell Distribution Width and Cancer-Specific Survival in Patients With Renal Cell Carcinoma Treated With Partial and Radical Nephrectomy

Życzkowski, Marcin; Rajwa, Paweł; Gabryś, Ewa; Jakubowska, Karolina; Jantos, Ewelina; Paradysz, Andrzej

doi:10.1016/j.clgc.2017.12.003

Cited by 25 publications

(23 citation statements)

References 48 publications

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“…As an inexpensive and easy-to-measure marker, RDW is gradually attracting attention and being used more and more widely in the clinic 9 – 12 . Emerging evidence suggests that RDW plays an important role in tumor diagnosis and prognosis 13 , such as renal cell cancer 14 , breast cancer 15 , ovarian cancer 16 , colorectal cancer 17 , esophageal cancer 18 , endometrial cancer 19 , and gastric cancer 20 .…”

Section: Introductionmentioning

confidence: 99%

Utility of red cell distribution width as a diagnostic and prognostic marker in non-small cell lung cancer

Song

Shi

Xiao

et al. 2020

Sci Rep

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An increasing number of studies have indicated that red blood cell distribution width (RDW) may be a novel biomarker for the diagnosis and prognosis of various malignancies. However, to date, data on the association of RDW with non-small cell lung cancer (NSCLC) are unclear. Our present study aimed to explore the value of RDW in NSCLC patients. A total of 338 NSCLC patients, 109 small cell lung cancer (SCLC) patients, and 302 healthy participants were retrospectively analyzed between January 2016 and December 2018. In the present study, we found that RDW was significantly increased in NSCLC patients. Receiver-operating characteristic (ROC) analysis showed that the area under the ROC curve (AUC) of RDW was 0.753 in discriminating NSCLC patients from healthy participants, the optimal cut-off value of RDW was 12.95, and the specificity and sensitivity were 76.33% and 76.16%, respectively. Further analysis found that RDW can enhance the diagnostic performance of Cyfra21-1 and NSE in discriminating NSCLC patients from healthy participants or SCLC patients. Among NSCLC patients, RDW was significantly correlated with TNM stage, T stage, N stage, M stage, and Cyfra21-1, indicating that RDW may be helpful for predicting the prognosis of NSCLC patients. Our findings suggest that RDW can be used as an auxiliary marker for the diagnosis and prognosis of NSCLC.

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Section: Introductionmentioning

confidence: 99%

Utility of red cell distribution width as a diagnostic and prognostic marker in non-small cell lung cancer

Song

Shi

Xiao

et al. 2020

Sci Rep

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“…High levels of RDW and other inflammatory markers have been implicated with aggressive cancers that show poor chemotherapy response. Similar results were noted in renal cell carcinoma treated with partial and radial nephrectomy according to an RDW cut-off of 13.9%, concluding that preoperative levels can aid in assessing the tumour aggressiveness [7]. The use of RDW as a prognostic indicator in cancer has been re-iterated in a meta-analysis of 17 studies across a number of tumour types, including lung and oesophageal cancer [12].…”

Section: Discussionmentioning

confidence: 67%

“…Numerous studies thereafter discussed different cut-off levels of RDW for patient stratification in cancer care. The selection of a 13.9% cutoff for RDW was established in recently published literature on renal cell carcinoma [ 7 ] and non-small cell lung cancer [ 8 ] to stratify high-risk and low-risk groups of cancer progression. Wang et al first showed the correlation between RDW at the time of diagnosis and renal cell carcinoma stage and grade, defining advanced disease with a RDW cut-off value of 13.15% [ 9 ].…”

Section: Introductionmentioning

confidence: 99%

Red cell differential width (RDW) as a predictor of survival outcomes with palliative and adjuvant chemotherapy for metastatic penile cancer

et al. 2020

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Purpose Red cell distribution width (RDW) measures red cells' size variability. Metastatic penile cancer displays poor chemotherapy response. As no validated prognostic predictor exists, we investigated whether RDW correlates independently with survival outcomes in metastatic penile cancer treated by chemotherapy. Methods Electronic chemotherapy files of patients with metastatic penile cancer (M1 or N3) from a large academic supraregional centre were retrospectively analysed between 2005 and 2018. Patients were stratified into RDW > 13.9% and < 13.9%, as per published data on RDW in renal cell carcinoma. Survival time was calculated from the date of chemotherapy initiation until the date of death. Results 58 patients were analysed. The RDW-high group (n = 31) had a poorer survival than the RDW-low group (n = 27). Median overall survival (mOS) in all patients was 19.0 months (95% CI 13.1-24.9). mOS for RDW-high was 15.0 months (95% CI 10.1-19.9) and 37.0 months (95% CI 32.3-43.1) for RDW-low. Kaplan-Meier curves showed a clear disparity in survival (log rank p = 0.025). Cox proportional hazard ratio for death, corrected for T-stage, grade, age and deprivation score was 0.43 (p = 0.04). Sub-analysis of the M1 patients showed mOS in RDW-high of 17 m (95% CI 11.6-22.4) vs. NR; HR for death of 0.42. N3 patients' mOS in RDW-high cohort was 30 months (95% CI 4.5-55.9) vs. 13 months (95% CI 1.8-24.2) in RDW-low; HR for death was 0.30. Conclusion RDW correlates independently with survival outcomes in metastatic penile cancer and may act as a potential predictor of survival outcomes for patients with metastatic penile cancer receiving chemotherapy.

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“…The solution might be found in cheap and easy obtainable blood-based indicators. Different complete blood count (CBC) parameters were reported to have an association with overall survival in RCC, such as neutrophil count, platelet count, neutrophil-to-lymphocyte ratio and mean platelet volume [16][17][18][19][20][21]. These markers are routinely used in everyday practice.…”

Section: Discussionmentioning

confidence: 99%

Mean platelet volume-to-lymphocyte ratio: a novel biomarker associated with overall survival in patients with nonmetastatic clear cell renal cell carcinoma treated with nephrectomy

et al. 2020

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Introduction Renal cell carcinoma is a highly aggressive malignancy that causes significant morbidity and mortality. The rising number of newly diagnosed renal tumors results in a great need to search for new preoperative markers to evaluate the course of the disease and to help select patients who would benefit the most from additional postoperative care. The aim of our study was to evaluate the prognostic value of mean platelet volume-to-lymphocyte ratio (MPVLR) in patients undergoing nephrectomy for nonmetastatic clear cell renal cell carcinoma (ccRCC). Materials and methods A total number of 344 patients with proven nonmetastatic ccRCC treated with radical or partial nephrectomy at our institution between January 2003 and December 2012 were included in our analysis. Based on the optimal cutoff value of MPVLR, which was determined by the receiver operating characteristic curve, our study population was divided into two groups, with low and high MPVLR. Differences in overall survival between groups were compared using the Kaplan-Meier method with log-rank testing. The Cox proportional hazards regression model was applied to perform univariate and multivariate analysis. Results Study subjects with high MPVLR were older and had more advanced tumors. Tumor necrosis and higher TNM stages were also more prevalent in this group of patients. Mortality in patients with high MPVLR was significantly higher than in patients with low MPVLR. In the multivariate analysis, after adjustment for pathological and clinical covariates, high MPVLR (≥ 3.61) was independently associated with higher long-term overall mortality in nonmetastatic ccRCC patients. Conclusion MPVLR is an easily obtainable prognostic marker for overall survival in nonmetastatic ccRCC patients treated with nephrectomy.

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The Relationship Between Red Cell Distribution Width and Cancer-Specific Survival in Patients With Renal Cell Carcinoma Treated With Partial and Radical Nephrectomy

Cited by 25 publications

References 48 publications

Utility of red cell distribution width as a diagnostic and prognostic marker in non-small cell lung cancer

Utility of red cell distribution width as a diagnostic and prognostic marker in non-small cell lung cancer

Red cell differential width (RDW) as a predictor of survival outcomes with palliative and adjuvant chemotherapy for metastatic penile cancer

Mean platelet volume-to-lymphocyte ratio: a novel biomarker associated with overall survival in patients with nonmetastatic clear cell renal cell carcinoma treated with nephrectomy

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