The relationship between QTc interval and cardiac autonomic neuropathy in diabetes mellitus

Pourmoghaddas, Ali; Hekmatnia, Ali

doi:10.1007/978-1-4419-9236-9_16

Cited by 18 publications

(24 citation statements)

References 6 publications

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“…Earlier clinical studies of diabetics have also reported a good correlation between prolonged QTc interval and overall cardiac mortality (61,62). Several studies have found a significant association between diabetic autonomic dysfunction and prolongation of the QTc interval (63)(64)(65)(66). Given the recently confirmed status of prolonged QTc interval as a marker of sudden cardiac death risk in a large, community-based cohort (described below), this parameter has potential for increased significance among diabetics.…”

Section: Diabetes As a Potential Predictor Of Sudden Cardiac Death Riskmentioning

confidence: 89%

Epidemiology of Sudden Cardiac Death: Clinical and Research Implications

Chugh

Reinier

Teodorescu

et al. 2008

Progress in Cardiovascular Diseases

580

449

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The current annual incidence of sudden cardiac death in the US is likely to be in the range of 180-250,000 per year. Coinciding with the decreased mortality from coronary artery disease, there is evidence pointing toward a significant decrease in rates of sudden cardiac death in the US during the second half of the twentieth century. However the alarming rise in prevalence of obesity and diabetes in the first decade of the new millennium both in the US and worldwide, would indicate that this favorable trend is unlikely to persist. We are likely to witness a resurgence of coronary artery disease and heart failure, as a result of which sudden cardiac death will have to be confronted as a shared and indiscriminate, worldwide public health problem. There is also increasing recognition of the fact that discovery of meaningful and relevant risk stratification and prevention methodologies will require careful prospective community-wide analyses, with access to large archives of DNA, serum and tissue that link with well-phenotyped databases. The purpose of this review is to summarize current knowledge of sudden cardiac death epidemiology. We will discuss the significance and strengths of community-wide evaluations of sudden cardiac death, summarize recent observations from such studies, and finally highlight specific potential predictors that warrant further evaluation as determinants of sudden cardiac death in the general population.

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Section: Diabetes As a Potential Predictor Of Sudden Cardiac Death Riskmentioning

confidence: 89%

Epidemiology of Sudden Cardiac Death: Clinical and Research Implications

Chugh

Reinier

Teodorescu

et al. 2008

Progress in Cardiovascular Diseases

580

449

View full text Add to dashboard Cite

show abstract

“…There is an increase incidence of intraventricular conduction blocks in diabetic patients than that of normal however this was not statistically significant. 8 …”

Section: Discussionmentioning

confidence: 99%

A study of electrocardiographic changes in type 2 diabetes patients

2015

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“…We have demonstrated with the use of a subject‐matched control population that, after correcting for heart rate effects upon the QT interval, pharmacologic sympathetic and parasymapthetic block exaggerate drug‐induced prolongation of the QT interval. While little is known about drug‐induced QT prolongation in the setting of autonomic dysfunction, there is evidence that QTc intervals are prolonged at baseline in patients with diabetic autonomic neuropathy, familial dysautonomia, and primary autonomic failure 25–28 . Sudden unexpected death in diabetics with cardiac autonomic neuropathy has been described and suggests a potential relationship between QT prolongation and a greater risk for sudden unexpected death, in addition to established diabetes‐related risk factors 29,30 …”

Section: Discussionmentioning

confidence: 99%