The relationship between pulmonary function and bone mineral density in healthy nonsmoking women: the Korean National Health and Nutrition Examination Survey (KNHANES) 2010

Jeon, Yun Kyung; Shin, Minseung; Kim, W. J.; Kim, Sung Sik; Kim, B. H.; Kim, S. J.; Kim, Y. K.; Shin, Yong‐Il; Kim, I. J.

doi:10.1007/s00198-014-2627-3

Cited by 16 publications

(16 citation statements)

References 30 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…A South Korean study that enrolled 456 premenopausal women who had never smoked showed that FVC and FEV 1 were correlated with BMD. 39 This is consistent with our findings showing that FEV 1 is an independent risk factor regardless of smoking history.…”

Section: Discussionsupporting

confidence: 93%

Prevalence, risk factors, and health-related quality of life of osteoporosis in patients with COPD at a community hospital in Taiwan

Lin

Chen

et al. 2015

COPD

View full text Add to dashboard Cite

BackgroundData regarding osteoporosis in COPD patients in Taiwan remain limited. The primary end point of this study was to evaluate the prevalence and risk factors of osteoporosis in COPD patients in Taiwan. The secondary end point was to examine the association between osteoporosis and health-related quality of life (HRQL) in COPD patients.Materials and methodsThis prospective cross-sectional study enrolled 125 COPD patients (mean age 73.6 years, forced expiratory volume in 1 second [FEV1] 1.19±0.43 L) who had bone mineral-density measurements performed consecutively. Demographic data, lung function, and HRQL including modified Medical Research Council dyspnea scale, St George’s Respiratory Questionnaire, oxygen-cost diagram, Center for Epidemiologic Studies – depression scale, and COPD Assessment Test scores were recorded.ResultsA total of 50 (40%) participants were diagnosed as having osteoporosis. In a multivariate logistic regression model including age, smoking amount (pack-year), body mass index (BMI), and FEV1, only BMI (odds ratio 0.824, 95% confidence interval 0.73–0.93; P=0.002) and FEV1 (odds ratio 0.360, 95% confidence interval 0.13–0.98; P=0.046) were negatively associated with an increased risk of osteoporosis in COPD patients. In addition, COPD patients with osteoporosis had significantly higher modified Medical Research Council dyspnea scale scores (1.7±0.8 vs 1.4±0.8, P=0.046), St George’s Respiratory Questionnaire scores (36.6 vs 28.0, P=0.01), and COPD Assessment Test scores (14.7±8 vs 11.5±7, P=0.019), and lower oxygen-cost diagram score (4.8±1.8 vs 5.4±1.6, P=0.045) than patients without osteoporosis.ConclusionThe prevalence of osteoporosis in COPD patients was high at a community hospital in Taiwan. BMI and FEV1 were the independent risk factors for osteoporosis in COPD. In addition, COPD patients with osteoporosis had worse HRQL than those without osteoporosis.

show abstract

Section: Discussionsupporting

confidence: 93%

Prevalence, risk factors, and health-related quality of life of osteoporosis in patients with COPD at a community hospital in Taiwan

Lin

Chen

et al. 2015

COPD

View full text Add to dashboard Cite

show abstract

“…This result was lower than the prevalence in other COPD studies and higher than that in the general population. [ 6 16 17 18 ] Studies have shown that patients with COPD usually have low BMD, impaired bone quality, and low bone turnover. [ 4 ] The mechanisms by which osteoporosis occurs in COPD patients are not yet known.…”

Section: Discussionmentioning

confidence: 99%

“…[ 20 22 23 ] The correlation between BMD and FEV 1 has also been demonstrated in the general population. Jeon et al[ 17 ] reported that FVC and FEV 1 are associated with BMD in healthy nonsmoking premenopausal women but not in postmenopausal women. Lee et al[ 24 ] found that FEV 1 was negatively correlated with lumbar spine BMD but not femur neck or total hip BMD in middle-aged Korean men.…”

Section: Discussionmentioning

confidence: 99%

Prevalence of Osteoporosis in Korean Patients with Chronic Obstructive Pulmonary Disease and Their Health-related Quality of Life According to the Korea National Health and Nutrition Examination Survey 2008–2011

Lee

Kwon

2017

J Bone Metab

View full text Add to dashboard Cite

BackgroundIn this study, we evaluated the prevalence of osteoporosis, risk factors associated with osteoporosis, and health-related quality of life (HRQOL) in clinically stable chronic obstructive pulmonary disease (COPD) patients.MethodsA total of 1,081 COPD patients were recruited from the Korea National Health and Nutrition Examination Survey (KNHANES) from July 2008 to May 2011. Bone mineral densities at the lumbar spine, femoral neck, and total proximal femur were measured using dual energy X-ray absorptiometry. HRQOL was assessed using the EuroQOL-5 dimensions (EQ-5D) questionnaire. To identify factors associated with osteoporosis and HRQOL in patients with COPD, multivariate regression analyses was performed.ResultsOf the 1,081 COPD patients, 191 (17.7%) were diagnosed with osteoporosis. There were significant differences in age, sex, smoking status, education level, house income, and body mass index (BMI) between the osteoporotic and non-osteoporotic groups. COPD patients with osteoporosis had significantly lower EQ-5D scores than the controls. In multivariate analyses, older age (odds ratio [OR]=1.10, P<0.001) was risk factor for osteoporosis. And patients of male sex (OR=0.06, P<0.001), high house income (OR=0.75, P=0.045), and high BMI (OR=0.74, P<0.001) were less likely to have osteoporosis. In addition, osteoporosis was associated with poor HRQOL (β=−0.21, P=0.023).ConclusionsThe prevalence of osteoporosis in COPD patients based on the 2008 to 2011 KNHANES data were relatively lower than that in physician-diagnosed COPD patients. In these COPD patients, older age, female sex, low household income, and low BMI increased the risk for osteoporosis.

show abstract

“…Decreased forced expiratory volume in one second (FEV1.0) and/or advanced Global Initiative for Chronic Obstructive Lung Disease (GOLD) stages have been demonstrated to be correlated with lower BMD. [ 6 8 10 27 37 ] Some [ 81 82 ] but not all [ 83 ] have reported correlation between BMD and FEV1.0 in the general population. In COPD patients the correlation of pulmonary function and/or GOLD stages with BMD seems to be in part mediated by BMI, whereas the correlation between BMD and with fracture prevalence was not always apparent.…”

Section: Disease-specific Risk Factors For Osteoporosis In Copdmentioning

confidence: 99%

Osteoporosis Associated with Chronic Obstructive Pulmonary Disease

2016

View full text Add to dashboard Cite

Recent epidemiological studies have revealed that osteoporosis is closely associated with common chronic diseases including diabetes, hypertension, chronic kidney disorders, and chronic obstructive pulmonary disease (COPD). COPD is a chronic inflammatory airway disease but now well known to be associated with various systemic comorbidities including osteoporosis. Osteoporosis and osteoporotic fractures are extremely common in COPD patients, which have significant impacts on their quality of life (QOL), activities of daily life (ADL), respiratory function, and possibly their prognosis. COPD-associated osteoporosis is however extremely under-recognized, hence undertreated. Recent studies have suggested that both decreased bone mineral density (BMD) and impaired bone quality compromise bone strength causing fractures in COPD. In COPD patients, various general clinical risk factors for osteoporosis are present including smoking, older age, low body weight, and physical inactivity. In addition, disease-related risk factors such as decreased pulmonary function, inflammation, glucocorticoid use and vitamin D deficiency/insufficiency have been linked to the development of osteoporosis in COPD. Increased awareness of osteoporosis in COPD, especially that of high prevalence of vertebral fractures is called upon among general physicians as well as pulmonologists. Routine screening for osteoporosis and risk assessment of fractures will enable physicians to diagnose COPD patients with comorbid osteoporosis at an early stage. Timely prevention of developing osteoporosis together with appropriate treatment of established osteoporosis may improve QOL and ADL of the COPD patients, preserve their lung function and eventually result in better prognosis in these patients.

show abstract

The relationship between pulmonary function and bone mineral density in healthy nonsmoking women: the Korean National Health and Nutrition Examination Survey (KNHANES) 2010

Abstract: Pulmonary function, including FVC and FEV1 are associated with BMD at FN in healthy nonsmoking premenopausal women but not in postmenopausal women.

Cited by 16 publications

References 30 publications

Prevalence, risk factors, and health-related quality of life of osteoporosis in patients with COPD at a community hospital in Taiwan

Prevalence, risk factors, and health-related quality of life of osteoporosis in patients with COPD at a community hospital in Taiwan

Prevalence of Osteoporosis in Korean Patients with Chronic Obstructive Pulmonary Disease and Their Health-related Quality of Life According to the Korea National Health and Nutrition Examination Survey 2008–2011

Osteoporosis Associated with Chronic Obstructive Pulmonary Disease

Contact Info

Product

Resources

About