The relationship between posttraumatic growth and health-related quality of life in adult cancer survivors: A systematic review

Liu, Zhunzhun; Doege, Daniela; Thong, Melissa S. Y.; Arndt, Volker

doi:10.1016/j.jad.2020.07.044

Cited by 56 publications

(44 citation statements)

References 38 publications

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“…Our results suggest that post-traumatic growth is positively correlated with HRQOL, is similar to the previous study conducted on cancer survivors [35]. Post-traumatic growth is related to perceived positive changes following traumatic life events rather than objective status [36].…”

Section: Variablessupporting

confidence: 89%

“…Post-traumatic growth is related to perceived positive changes following traumatic life events rather than objective status [36]. Therefore, the results indicate that kidney transplant recipients who have experienced posttraumatic growth may have evaluated HRQOL more positively, just as cancer survivors who have experienced post-traumatic growth rate HRQOL [35]. As the process of post-traumatic growth may involve small and slow alterations over time in kidney transplant recipients [37], developing a program that improves post-traumatic growth can be difficult.…”

Section: Variablesmentioning

confidence: 88%

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Factors associated with health-related quality of life in kidney transplant recipients in Korea

2021

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Health-related quality of life (HRQOL) of kidney transplant recipients is an outcome evaluation after kidney transplants. Therefore, we investigated the associations among perceived health status, social support, self-determination, post-traumatic growth, and kidney transplant recipients’ HRQOL. This study involved a descriptive, self-report survey of 163 kidney transplant recipients visiting an outpatient solid organ transplant center in South Korea. Participants’ general and transplant characteristics, perceived health status, post-traumatic growth, social support, self-determination, and HRQOL were collected. Data were statistically analyzed using the software SPSS version 25.0. HRQOL showed statistically significant positive correlation with perceived health status (r = .56, p < .001), post-traumatic growth (r = .18, p = .022), social support (r = .25, p = .002), and self-determination (r = .36, p < .001). The factors affecting HRQOL were perceived health status (β = 0.47, p < 0.001), post-transplant occupation (β = 0.17, p = 0.009), and income source (β = -0.13, p = 0.046). The explanatory power of these variables was 34.8% (F = 28.81, p < 0.001). In the subdomains of HRQOL, the factors influencing HRQOL of mental component summary were perceived health status (β = 0.45, p < 0.001), self-determination (β = 0.27, p < 0.001), and education level (β = 0.18, p = 0.006). The explanatory power of these variables was 34.8% (F = 28.81, p < 0.001). To promote the HRQOL of kidney transplant recipients, an institutional system to assist kidney transplant recipients in returning to work needs to be developed. Additionally, creating an environment that allows kidney transplant recipients to act with self-determination, and developing intervention programs that can enhance self-determination will contribute to enhancing the HRQOL of kidney transplant recipients.

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Section: Variablessupporting

confidence: 89%

Section: Variablesmentioning

confidence: 88%

Factors associated with health-related quality of life in kidney transplant recipients in Korea

2021

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“…In terms of correlates, age, sex, time since diagnosis, type of treatment, and cancer stage have been associated with PTG, but evidence is inconsistent [9,10]. More consistent positive relationships with social support and resilience have been reported [9,14] and PTG is positively associated with health-related quality of life [15]. However, while this body of research has been valuable in quantifying the extent of PTG among survivors, it has limitations, including crosssectional designs and significant heterogeneity [15,16].…”

Section: Introductionmentioning

confidence: 99%

“…More consistent positive relationships with social support and resilience have been reported [9,14] and PTG is positively associated with health-related quality of life [15]. However, while this body of research has been valuable in quantifying the extent of PTG among survivors, it has limitations, including crosssectional designs and significant heterogeneity [15,16]. Nor can it shed light on pathways by which PTG develops or whether any aspects of the experience of PTG are specific to cancer.…”

Section: Introductionmentioning

confidence: 99%

Post-traumatic growth after cancer: a scoping review of qualitative research

Menger

Halim

Rimmer

et al. 2021

Support Care Cancer

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Purpose Interest is growing in post-traumatic growth (PTG) after cancer prompted, in part, by observations of positive associations with health-related quality of life. Qualitative research provides valuable insight into survivors’ experiences. We conducted a scoping review of qualitative evidence on PTG in cancer, determining the number, nature, range and scope of studies, and gaps in the literature. Methods We systematically searched Medline, Scopus, CINAHL, Web of Science, and PsycINFO for qualitative research exploring positive changes after cancer published from 1996. From eligible studies, we extracted: terms used for PTG; design, methodological orientation, and techniques, and participant characteristics. Using descriptive mapping, we explored whether study findings fit within Tedeschi and Calhoun’s PTG framework, and evidence for unique positive changes post-cancer. Results Twenty-eight studies were eligible. Cancer sites included were: breast, 14; mixed, 6; haematological, 4; head and neck cancer, 2; bone, 1, and testis, 1. Multiple studies were conducted in: the USA (12), Australia (3), Iran (2), and the UK (2). Twenty-three studies collected data using individual interviews (21) or focus groups (2). Definitions of PTG varied. Studies largely focused on descriptive accounts of PTG. Findings mapped onto existing PTG dimensions; health behaviour changes were often reported, under ‘new possibilities’. Conclusions A range of PTG outcomes can occur after cancer. Positive health behaviour changes warrant further exploration. Future research should include more diverse patient populations, collect longitudinal data, and focus on pathways towards positive changes.

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“…1 However, the consequences of cancer and of its treatment, including the risk of recurrent cancer, other chronic diseases, and persistent adverse effects, can significantly affect physical function and quality of life. 2,3 It is, therefore, necessary that effective care plans are developed with the aim of improving cancer survivorship.…”

Section: Introductionmentioning

confidence: 99%

Oxaliplatin, an Anticancer Agent, Causes Erectile Dysfunction in Rats due to Endothelial Dysfunction

Kataoka

Mori

Suzuki

et al. 2021

The Journal of Sexual Medicine

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Background: Chemotherapeutics, one of the standard treatment options for cancer worldwide, have various adverse effects, including erectile dysfunction (ED). Aim: To investigate erectile function in an animal model after administration of the anticancer agent oxaliplatin (L-OHP). Methods: Male Wistar/ST rats were divided into 2 groups: L-OHP rats (n = 21), which were intravenously administered L-OHP (4 mg/kg; twice a week for 4 weeks), and Control rats (n = 21), which were injected with the same volume of 5% glucose solution, using the same dosing schedule. At the end of the study period, erectile function was evaluated by measuring intracavernous pressure (ICP) and mean arterial pressure (MAP) after cavernous nerve stimulation (n = 9−10). Endothelial function was evaluated with an isometric tension study using corpus cavernosum strips (n = 11). Western blot analysis was used to assess neuronal nitric oxide (nNOS) and endothelial NO synthase (eNOS) protein levels (n = 7). Real-time quantitative polymerase chain reaction (qRT-PCR) was used to assess the expression of inflammation-and oxidative stress-related markers (nicotinamide adenine dinucleotide phosphate oxidase-1, p22 phox , interleukin [IL]-6, and nuclear factor-kappa B) (n = 6). Statistical significance was determined using the Student's t-test. Outcomes: The L-OHP group had a significantly lower ICP:MAP ratio than the control group (P < .05). Compared to the Control group, the L-OHP group exhibited significantly lower responses to ACh and eNOS protein levels and significantly higher inflammatory biomarker levels. Clinical Translation: The results based on this animal model indicate that use of the anticancer agent L-OHP should be considered as a risk factor for ED occurring via reduction of NO bioavailability in humans; our results provide possible treatment strategies for maintaining the erectile function of cancer survivors. Strengths and limitations: Our study showed that the anticancer agent L-OHP has the propensity to cause ED in rats. A major limitation of this study is the lack of an established cure for ED associated with L-OHP and the lack of clinical evidence. Conclusions: L-OHP causes ED in rats via reduction of NO bioavailability caused by endothelial dysfunction.

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The relationship between posttraumatic growth and health-related quality of life in adult cancer survivors: A systematic review

Cited by 56 publications

References 38 publications

Factors associated with health-related quality of life in kidney transplant recipients in Korea

Factors associated with health-related quality of life in kidney transplant recipients in Korea

Post-traumatic growth after cancer: a scoping review of qualitative research

Oxaliplatin, an Anticancer Agent, Causes Erectile Dysfunction in Rats due to Endothelial Dysfunction

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