The relationship between polymorphism of four serotonic genes (5-HTTL, 5-HT1A, 5-HT2A, and MAOA) and personality traits in wrestlers and control group

Butovskaya, P. R.; Lazebnij, O. E.; Fekhretdinova, D. I.; Васильев, В. А.; Prosikova, E. A.; Лысенко, В. В.; Udina, I. G.; Butovskaya, Marina L.

doi:10.3103/s0891416815040035

Cited by 3 publications

(1 citation statement)

References 13 publications

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“…Rs6311 specifically has been shown to interact with the serotonin transporter gene (5-HTTLPR) and education level to predict novelty-seeking in a Spanish sample (Saiz et al, 2010). In a study among Russian wrestlers, rs6311 interacted with gender to predict openness to experience, as measured by the NEO-5 (Butovskaya et al, 2015). Additionally, an understanding of paradoxical expression—that a condition such as potentiation of serotonin transmission can both increase sensitivity to stressful experiences as well as increase openness to experiences—is important to understanding the relation among serotonin gene receptors, spirituality, and pathology.…”

Section: Potential Candidate Single Genes For Spirituality and Depres...mentioning

confidence: 99%

Genetic correlates of spirituality/religion and depression: A study in offspring and grandchildren at high and low familial risk for depression.

Anderson¹,

Miller²,

Wickramaratne³

et al. 2017

Spirituality in Clinical Practice

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Rationale Possible genetic correlates of spirituality and depression have been identified in community samples. We investigate some of the previously identified candidates in a sample of families at both high and low-risk for depression. Method Offspring and grandchildren of individuals at high and low-risk for depression, participating in a multi-wave thirty-year longitudinal study, were assessed for seven SNPS drawn from four single gene candidates associated with systems implicated in both depression and spirituality: Serotonin (5-HT1B and 5-HT2A), Dopamine (DRD2), Oxytocin (OT) and Monoamine Vesicular Transporter (VMAT1). Results Dopamine (DRD2) Serotonin (5-HT1B), their Transporter (VMAT1) and Oxytocin (OXTR) were positively associated with a high level of importance of spirituality or religion (S/R) in the group at low familial risk for depression. DRD2 minor allele was associated with both lifetime major depressive disorder (MDD) and spirituality in the low-risk group for depression. No SNPs were related to S/R in the group at high familial risk for depression. OXTR was associated with lifetime MDD in the full sample. Conclusion Genes for dopamine, serotonin, their vesicular transporter, and oxytocin may be associated with S/R in people at low familial risk for depression. Genes for dopamine may be associated both with S/R and increased risk for depression in people at low-risk for depression, suggesting a common pathway or physiology to mild to moderate depression. MDD is associated with oxytocin across risk groups. In the high-risk group, phenotypic expression of S/R may be suppressed. Implications The shared association of DRD2 by S/R and depression, generally found to be inversely related, calls for further research on their common physiological pathways, and the phenotypic expression of these pathways based upon use and environment. Prevention for offspring at high familial risk for depression might include support for the development of child spirituality.

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Section: Potential Candidate Single Genes For Spirituality and Depres...mentioning

confidence: 99%

Genetic correlates of spirituality/religion and depression: A study in offspring and grandchildren at high and low familial risk for depression.

Anderson¹,

Miller²,

Wickramaratne³

et al. 2017

Spirituality in Clinical Practice

View full text Add to dashboard Cite

show abstract

Search for Correlation between Indicators of Tolerance to Extreme Impacts and Levels of Individual Heterozygosity

et al. 2018

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The Genetic Profile of Combat Sport Athletes: A Systematic Review of Physiological, Psychological and Injury Risk Determinants

Anastasiou,

Morris,

Akam

et al. 2024

IJERPH

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This systematic review aims to assess the genetic determinants influencing combat sports performance and address potential gaps in previous reviews. Twenty-four selected studies were analysed, investigating genetic influences on physiological performance, psychological traits, psychophysiological factors like pain perception, and injury susceptibility in combat sport athletes. The systematic literature search, using keywords, encompassed PubMed, Scopus, SportDiscus, Medline, and Google Scholar. The Covidence systematic review management software facilitated the screening process and the creation of the PRISMA flow diagram. The quality assessment complied with the PRISMA guidelines, featuring a custom 10-point scale and the STREGA criteria for more reliable study inclusion. Collectively, the 24 studies incorporated 18,989 participants, of which 3323 were combat athletes of majority European ancestry (71.7%) from various combat sports disciplines. Twenty-five unique genetic variants were significantly associated with combat sports performance across diverse domains. These included physiological performance (nine genetic variants), psychological traits (ten genetic variants), psychophysiological factors (one genetic variant), and injury susceptibility (four genetic variants). In conclusion, this systematic review lays the foundation for a more comprehensive exploration of the association between genetics and athletic performance in the demanding arena of combat sports, offering valuable insights for talent identification, training optimisation, and injury prevention.

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The relationship between polymorphism of four serotonic genes (5-HTTL, 5-HT1A, 5-HT2A, and MAOA) and personality traits in wrestlers and control group

Cited by 3 publications

References 13 publications

Genetic correlates of spirituality/religion and depression: A study in offspring and grandchildren at high and low familial risk for depression.

Genetic correlates of spirituality/religion and depression: A study in offspring and grandchildren at high and low familial risk for depression.

Search for Correlation between Indicators of Tolerance to Extreme Impacts and Levels of Individual Heterozygosity

The Genetic Profile of Combat Sport Athletes: A Systematic Review of Physiological, Psychological and Injury Risk Determinants

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