The relationship between polycyclic aromatic hydrocarbons exposure and serum klotho among adult population

Abstract

Background Klotho is an important factor involving aging process. Recently, polycyclic aromatic hydrocarbons (PAHs) exposure was reported to have adverse impact on DNA methylation associated with aging. The aim of the current study was to determine the relationship between serum klotho and PAHs exposure in an adult population. Methods A total of 2597 participants obtained from NHANES 2015–2016 were included in this cross-sectional study. Serum klotho levels were analyzed by enzyme-linked immunosorbent assay (ELISA). PAHs exposure was estimated by urinary sample using liquid chromatography-tandem mass spectrometry. The relationship between serum klotho and exposure to PAHS was analyzed by a multivariable linear regression model. Results 2-napthol and 3-fluorene were significantly associated with decreased klotho. After fully adjusting pertinent variables, PAH exposure was significantly associated with decreased klotho, particularly in men. Conclusion In the present study we highlighted the significant association between PAHs exposure and serum klotho levels. The importance of environmental effect on aging process and age-related disorders should be paid more attention and clinical intervention is necessary.

Tangeretin Supplementation Mitigates the Aging Toxicity Induced by Dietary Benzo[a]pyrene Exposure with Aberrant Proteostasis and Heat Shock Responses in Caenorhabditis elegans

“…Exposure to PAHs, including BaP, has been associated with accelerated aging phenotypes in humans. − In our study, we showed that chronic exposure to BaP aggravated aging-related declines in C. elegans , including the worsening decline in pharyngeal pumping and ROS accumulation during aging (Figure ). Head thrashing is a common indicator of vitality for C. elegans .…”

“…Recently, emerging evidence has linked daily exposure to PAHs to poorer aging indicators in human subjects, including increased BaP-DNA adducts, reduced telomere length in leukocytes, and increased mitochondrial DNA copy number . Exposure to PAHs is also associated with significantly reduced serum Klotho levels in humans and is associated with increased DNA methylation . Advances in gerontology have revealed mechanistic associations between aging and cancer, and several common hallmarks, such as chronic inflammation, genomic instability, and epigenetic abnormalities, have been suggested .…”