The relationship between poly(lactide‐co‐glycolide) monomer ratio, molecular weight and hollow fibre membrane scaffold morphology

Ellis, Marianne; Chaudhuri, Julian B.

doi:10.1002/apj.505

Cited by 4 publications

(3 citation statements)

References 29 publications

(24 reference statements)

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“…A particularly versatile yet simple and cheap scaffold fabrication technique, using mild conditions, is phase inversion membrane casting. Membrane morphology depends on many physical and chemical factors, including monomer ratio, molecular weight and polydispersity index (Ellis and Chaudhuri 2010), as well as the properties of the polymer solution and the non-solvent (Ellis and Chaudhuri 2007). However, further understanding of the process parameters is necessary to accurately determine the appropriate casing conditions.…”

Section: Introductionmentioning

confidence: 99%

Surfactant-free poly(lactide-co-glycolide) honeycomb films for tissue engineering: relating solvent, monomer ratio and humidity to scaffold structure

Jones

Davidson

et al. 2010

Biotechnol Lett

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One-step surfactant-free, water-droplet templating has been developed as a fabrication method for a poly(lactide-co-glycolide) (PLGA) film that can be used as a model to investigate the relationship between solvent, monomer ratio, polymer concentration and humidity on its structure. The resulting material is a honeycomb-structured film. Formation of this structure was highly sensitive to solvent, monomer ratio, polymer concentration and humidity. Surfactant-free, water-droplet templating thus allows investigation of fabrication parameters and that PLGA monomer ratio selection is important for scaffold structure but not for MG63 cell attachment and proliferation.

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Section: Introductionmentioning

confidence: 99%

Surfactant-free poly(lactide-co-glycolide) honeycomb films for tissue engineering: relating solvent, monomer ratio and humidity to scaffold structure

Jones

Davidson

et al. 2010

Biotechnol Lett

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“…The above three papers focused on one of the core issues in TE, i.e., the effect of biomaterial and surface modification on cell behavior and tissue construction. On a slightly different context, the paper by Ellis and Chaudhuri [6] evaluates the morphologies of hollow fibre membrane scaffolds fabricated from six commercial poly(lactide-co-glycolide) (PLGA) polymers with different lactide: glycolide (PLA : PGA) molar ratios. This paper responds to the fact that the morphological characteristics of scaffolds are fundamental to their use for cell culture in regenerative medicine applications.…”

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confidence: 99%

- Microvascular Imaging Methods for Tissue Engineering

Thimm¹,

Hofmann

Müller³

2014

Scaffolds for Tissue Engineering

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This special theme seeks to highlight the recent trends and innovative developments in tissue engineering (TE). The development of TE as an area of study has been rapid in the last one decade and, its definition is very broad depending on each individual's interpretation of the subject. For example, Freed and Novakovic [1] interpreted TE as having three major components: metabolically active cells, polymeric micro-carriers (scaffolds) and bioreactors. However, one may also view TE as a technology for culturing functional cells and tissues which, in particular, aims to create an in vitro environment that regulates cells and tissues development and maintenance in vivo. In general, topics of TE research can include but are not limited to cellular fate processes, methods of tissue characterization, tissue culture methods including TE bioreactors, biomaterials, three dimensional tissues like assemblies, design methods for TE scaffold, characterization of cell-scaffold material interactions, etc. Apart from these areas, research work on multi-scale analysis, mass transport and fluid flow in TE systems, and optimization methods for tissue culture systems are also found.

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“…These three papers focused on one of the core issues in TE that is the effect of biomaterial and surface modification on cell behaviour and tissue construction. On a slightly different context, the paper by Ellis and Chaudhuri evaluates the morphologies of hollow fibre membrane scaffolds fabricated from six commercial poly(lactide‐co‐glycolide) (PLGA) polymers with different lactide : glycolide (PLA : PGA) molar ratios. This paper responds to the fact that the morphological characteristics of scaffolds are fundamental to their use, for cell culture in regenerative medicine applications.…”

mentioning

confidence: 99%