The relationship between physical activity and heart rate variability in orthotopic heart transplant recipients

Lai, Fu Chih; Chang, Wen Lin; Jeng, Chii

doi:10.1111/j.1365-2702.2012.04070.x

Cited by 7 publications

(4 citation statements)

References 35 publications

(60 reference statements)

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“…21 Also, exercise training and moderate physical activity following transplantation could improve the state of cardiac reinnervation, 50,76 as shown by improving HRV. 77 It seems that peak power output remains lower in HTx recipients compared to controls. 16,60,62 Exercise duration was found to be lower in early and late HTx recipients compared to controls for up to 5 years post-HTx, 21,29,48,62,71 whereas it seems to be higher in reinnervated compared to denervated recipients with higher reduction in reinnervated recipients in response to b-blockade.…”

Section: I-meta-iodobenzylguanidine (Mibg)mentioning

confidence: 98%

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Early Denervation and Later Reinnervation of the Heart Following Cardiac Transplantation: A Review

Awad

Czer

Hou

et al. 2016

JAHA

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Section: I-meta-iodobenzylguanidine (Mibg)mentioning

confidence: 98%

“…Exercise performance, in general, was associated with a reduced peak HR in denervated HTx recipients . Also, exercise training and moderate physical activity following transplantation could improve the state of cardiac reinnervation, as shown by improving HRV …”

Section: Exercise Tolerancementioning

confidence: 99%

Early Denervation and Later Reinnervation of the Heart Following Cardiac Transplantation: A Review

Awad

Czer

Hou

et al. 2016

JAHA

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“…Lai et al [ 30 ] indicated that OHT recipients’ HRV was significantly lower than that of healthy adults in terms of mean, SD RR , total power, low frequency, low frequency (nu), high frequency and low frequency/high frequency. In this study we found similarly that the HRV of OHT patients was severely decreased, as compared to that of CABG patients.…”

Section: Discussionmentioning

confidence: 99%

The use of heart rate variability measures as indicators of autonomic nervous modulation must be careful in patients after orthotopic heart transplantation

Chen

Shih

et al. 2015

J Clin Monit Comput

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The precise relation between heart rate variability (HRV) and autonomic re-innervation has not been established explicitly in patients after orthotopic heart transplantation (OHT), but can be inferred from the fact that the HRV is reduced immediately after OHT and may increase gradually with time. The aim of this study was to investigate the residual HRV in patients about 1–2 years after OHT, as compared with patients after coronary artery bypass graft (CABG) surgery. Thirteen patients who had received OHT and 14 patients who had received CABG surgery were recruited. HRV analysis was performed and the HRV measures in supine position were compared between these two groups of patients. We found that the mean (mRRI), standard deviation and coefficient of variation of RR intervals, total power, very low frequency power (VLFP), low frequency power, high frequency power (HFP), normalized VLFP (nVLFP) and low-/high-frequency power ratio in the OHT group were all significantly decreased, while the heart rate (HR) and normalized HFP (nHFP) were significantly increased, as compared with the CABG group. The decrease in HRV was more severe in the VLFP region. A smaller nVLFP and a greater nHFP were associated with a smaller mRRI and a larger HR in the OHT patients. The slope of the power law relation of HRV became positive in OHT patients, instead of negative in CABG patients. We conclude that patients after OHT have residual HRV which were characterized by severely depressed time and frequency domain HRV, increased HR and nHFP, decreased nVLFP, and positive slope of the power-law relation of HRV. The use of nHFP as the indicator of vagal modulation and the use of nVLFP as the indicator of renin-angiotensin modulation, thermoregulation and vagal withdrawal must be careful in the OHT patients.

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“…The imbalance in the two branches of autonomic nervous modulation may contribute to and reflect many kinds of illness. HRV analysis has long been used in the assessment of many diseases such as acute myocardial infarction (AMI) ( 3 , 4 ), post-myocardial infarction status ( 5 ), and orthotopic heart transplantation ( 6 ).…”

Section: Introductionmentioning

confidence: 99%

Decomposition of Heart Rate Variability Spectrum into a Power-Law Function and a Residual Spectrum

Kuo

2016

Front. Cardiovasc. Med.

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The power spectral density (PSD) of heart rate variability (HRV) contains a power-law relationship that can be obtained by plotting the logarithm of PSD against the logarithm of frequency. The PSD of HRV can be decomposed mathematically into a power-law function and a residual HRV (rHRV) spectrum. Almost all rHRV measures are significantly smaller than their corresponding HRV measures except the normalized high-frequency power (nrHFP). The power-law function can be characterized by the slope and Y-intercept of linear regression. Almost all HRV measures except the normalized low-frequency power have significant correlations with the Y-intercept, while almost all rHRV measures except the total power [residual total power (rTP)] do not. Though some rHRV measures still correlate significantly with the age of the subjects, the rTP, high-frequency power (rHFP), nrHFP, and low-/high-frequency power ratio (rLHR) do not. In conclusion, the clinical significances of rHRV measures might be different from those of traditional HRV measures. The Y-intercept might be a better HRV measure for clinical use because it is independent of almost all rHRV measures. The rTP, rHFP, nrHFP, and rLHR might be more suitable for the study of age-independent autonomic nervous modulation of the subjects.

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The relationship between physical activity and heart rate variability in orthotopic heart transplant recipients

Abstract: We suggest that clinical care providers have to encourage heart transplant recipients to engage in moderate physical activity.

Cited by 7 publications

References 35 publications

Early Denervation and Later Reinnervation of the Heart Following Cardiac Transplantation: A Review

Early Denervation and Later Reinnervation of the Heart Following Cardiac Transplantation: A Review

The use of heart rate variability measures as indicators of autonomic nervous modulation must be careful in patients after orthotopic heart transplantation

Decomposition of Heart Rate Variability Spectrum into a Power-Law Function and a Residual Spectrum

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