The relationship between periodontal status and hyperglycemia after kidney transplantation

Gomes, Samira Vasconcelos; Rodrigues, Vandílson Pinheiro; Nunes-dos-Santos, Danila Lorena; Pereira, António Luis; Peres, Marco Aurélio

doi:10.1007/s00784-021-04011-6

Cited by 2 publications

(3 citation statements)

References 49 publications

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“…Our results showed no significant difference of DM incidence in the two groups defined according to periodontitis severity, although it is important to note that in our study a small number of KTRs had DM, which is in line with data from the literature 48 . However, the recently published study of Gomes et al., which investigated the association between periodontal status and hyperglycemia after KT, showed that periodontitis severity and CVD were positively associated with hyperglycemia 49 . Therefore, further studies with a larger sample size and a longitudinal design are needed to thoroughly investigate the association between the severity of periodontitis and hyperglycemia in KTRs.…”

Section: Discussionsupporting

confidence: 90%

“…48 However, the recently published study of Gomes et al, which investigated the association between periodontal status and hyperglycemia after KT, showed that periodontitis severity and CVD were positively associated with hyperglycemia. 49 Therefore, further studies with a larger sample size and a longitudinal design are needed to thoroughly investigate the association between the severity of periodontitis and hyperglycemia in KTRs.…”

Section: Discussionmentioning

confidence: 99%

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Risk factors of severe periodontitis in kidney transplant recipients: A case‐control study

Roguljić

Vučković

Gelemanović

et al. 2023

Journal of Periodontology

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Background: Kidney transplant recipients (KTRs) represent a vulnerable group of patients who develop a number of comorbidities. Severe periodontitis (SP) is associated with the most common chronic systemic diseases including kidney diseases. The objective of this study was to explore the risk factors for SP in KTRs.Methods: In this study, KTRs were divided into those with or without periodontitis and in relation to the severity of periodontitis. A comprehensive medical and periodontal examination was performed and evaluated. Multivariate logistic regression was performed to examine possible risk factors for SP among KTRs. Results: A total of 100 KTRs were included in the analysis, of which 87% had periodontitis. Significant predictors of periodontitis were older age (OR = 1.07, 95% CI [1.01, 1.13], p = 0.016) and lower skeletal muscle mass (OR = 0.88, 95% CI [0.78, 0.99], p = 0.035). When examining periodontitis severity, predictors of SP (n = 21, 24%) were increased levels of uric acid (OR = 1.01, 95% CI [1.00, 1.02], p = 0.022) and dental plaque (OR = 1.04, 95% CI [1.01, 1.07], p = 0.013). In the subset analysis that included only KTRs with measured advanced glycation end products (AGE) (n = 47), 34% (n = 16) had SP. The predictors of SP were AGE (OR = 3.89, 95% CI [1.28, 11.82], p = 0.017) and dental plaque (OR = 1.07, 95% CI [1.01, 1.13], p = 0.028).Conclusions: KTRs with SP had significantly higher uric acid levels and AGE, which may contribute to the systemic health status of this patient population.

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Section: Discussionsupporting

confidence: 90%

Section: Discussionmentioning

confidence: 99%

Risk factors of severe periodontitis in kidney transplant recipients: A case‐control study

Roguljić

Vučković

Gelemanović

et al. 2023

Journal of Periodontology

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“…In agreement, consistencies were shown by Nunes-Dos-Santos et al [ 31 ], who found in a recent systematic review a correlation between periodontal disease and decreased kidney graft functionality. Nonetheless, in 2022 Gomes et al [ 32 ] suggested a possible role of periodontitis in the onset of hyperglycemia in KT patients. By contrast, results from different studies are in disagreement with the above-mentioned conclusions.…”

Section: Discussionmentioning

confidence: 99%

Evaluation of the correlation between oral infections and systemic complications in kidney transplant patients: a retrospective pilot study

et al. 2022

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Background Data regarding the efficacy of the dental clearance required prior to kidney transplantation (KT) for preventing post-transplant complications is controversial. The aim of this retrospective study was to investigate a possible correlation between any untreated oral infectious foci and the onset of systemic complications in KT patients. Methods Patients scheduled for regular check-ups during the post-transplant period were visited at the C.I.R. Dental School in Turin, Italy. Patients were asked to bring orthopantomography (OPT) acquired prior to transplantation to compare the possible presence of untreated infectious foci at the time of transplantation with the time of their post-transplant visit. Patients were then divided, according to the evaluation of the OPT obtained prior to the transplantation, into two groups according to their dental status prior to the transplant. “Group Infected” was comprised of patients with no dental clearance, and “Group Clear” included patients with dental clearance. The medical records were then retrospectively reviewed for the evaluation of any systemic complications that occurred after transplantation. The following medical complications were considered: fever, pneumonia, urinary tract infections, systemic infections, kidney rejection, and death. Complications were divided in two groups: early complications, which occurred within 100 days of transplantation, and late complications, which occurred more than 100 days after transplantation. Results A total of 77 patients were enrolled in the study. Group Infected was composed of 19 subjects (25%), while Group Clear was composed of 58 patients (75%). In Group Infected, 13 (68%) patients developed complications within 100 days of transplantation, and 11 (58%) did so after 100 days. In Group Clear, 31 (53%) patients had complications within 100 days of the transplant, and 23 (40%) did after 100 days. Patients in Group Infected had a statistically significant increase in episodes of fever (p = 0.03), compared to Group Clear, with a higher relative risk (RR) of 3.66 in the first 100 days after transplantation. Conclusion Within the limitations of the present retrospective pilot study, and based on the results, a correlation between the absence of dental clearance prior to KT and a higher RR of developing a fever within the first 100 days post transplantation was highlighted. The present results encourage doctors to continue research on the topic, which remains controversial. Further prospective studies are required to confirm the results of the present study.

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The relationship between periodontal status and hyperglycemia after kidney transplantation

Cited by 2 publications

References 49 publications

Risk factors of severe periodontitis in kidney transplant recipients: A case‐control study

Risk factors of severe periodontitis in kidney transplant recipients: A case‐control study

Evaluation of the correlation between oral infections and systemic complications in kidney transplant patients: a retrospective pilot study

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