The relationship between oxidative stress markers and endometrial hyperplasia: A case-control study

Yıldırım, Engin; Turkler, Can; Görkem, Ümit; Şimşek, Ömer Faruk; Yılmaz, Ercan; Aladag, Hulya

doi:10.4274/tjod.galenos.2021.16132

Cited by 6 publications

(3 citation statements)

References 23 publications

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“…Moreover, alarin could attenuate oxidative stress in heart failure rats [ 43 ]. High oxidative stress levels seem to be involved in the pathophysiology of various diseases, including diabetes, inflammatory diseases, cancers, and especially atherosclerosis [ 44 , 45 ]. These results suggest that elevated alarin levels can be used to assess atherosclerosis progression.…”

Section: Discussionmentioning

confidence: 99%

Serum Tenascin-C and Alarin Levels Are Associated with Cardiovascular Diseases in Type 2 Diabetes Mellitus

Zhu

et al. 2022

International Journal of Endocrinology

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Background. Tenascin-C (TNC), an extracellular matrix glycoprotein, is elevated in inflammatory and cardiovascular pathologies, whereas alarin, a novel orexigenic peptide, participates in insulin resistance and glycometabolism. The roles of these molecules in individuals with cardiovascular disease (CVD) and type 2 diabetes mellitus (T2DM), clinical conditions associating with metabolic disorders, and chronic inflammation, remain controversial. Our study aimed at determining the potential role of TNC and alarin in CVD adult patients with T2DM. Methods. This was a cross-sectional study. Basic and clinical information for 250 patients with T2DM were analyzed. Based on their cardiovascular disease status, participants were assigned into the CVD and non-CVD groups. Serum TNC and alarin levels were assessed by enzyme-linked immunosorbent assay (ELISA). Results. Serum TNC and alarin concentrations in the CVD group were significantly higher than those of the non-CVD group. Moreover, serum TNC levels were positively correlated with age, waist circumference, and waist-hip ratio; however, they were negatively correlated with TC, LDL-C, and eGFR levels. Alarin levels were positively correlated with BMI, waist circumference, and hip circumference. In logistic regression models, TNC and alarin were also established to be independent determinants for CVD in T2DM patients and their increases were associated with CVD severity. Receiver operating characteristic (ROC) curve analysis showed that the area under curve (AUC) values for TNC and alarin were 0.68 and 0.67, respectively. TNC and alarin were good predictors of CVD occurrence. When the cutoff value for TNC was 134.05 pg/mL, its sensitivity was 69.47% while its specificity was 61.29%. When the cutoff value for alarin was 142.69 pg/mL, sensitivity and specificity were 38.95% and 90.97%, respectively. Conclusion. Elevated TNC and alarin levels are independently associated with the occurrence and severity of CVD in T2DM individuals. Therefore, these two biomarkers are potential diagnostic and prognostic indicators for CVD in diabetics.

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Section: Discussionmentioning

confidence: 99%

Serum Tenascin-C and Alarin Levels Are Associated with Cardiovascular Diseases in Type 2 Diabetes Mellitus

Zhu

et al. 2022

International Journal of Endocrinology

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“…There is evidence to support the theory that estrogen-induced tumors result from the redox cycling of estrogen metabolites [ 41 ]. Estrogens and their catecholic metabolites have been reported to act as prooxidants [ 41 , 42 ]. The harmful effects of these metabolites can be associated either directly by making semiquinone radicals or indirectly as a result of their ability to undergo a redox cycle and form reactive oxygen species ROS [ 13 , 42 , 43 ].…”

Section: Contentmentioning

confidence: 99%

“…Estrogens and their catecholic metabolites have been reported to act as prooxidants [ 41 , 42 ]. The harmful effects of these metabolites can be associated either directly by making semiquinone radicals or indirectly as a result of their ability to undergo a redox cycle and form reactive oxygen species ROS [ 13 , 42 , 43 ]. 2-Hydroxyestradiol, a significant E2 metabolite, is mostly catalyzed by CYP1A2 and CYP3A4 in the liver and by CYP1A1 in extrahepatic tissues [ 44 ].…”

Section: Contentmentioning

confidence: 99%

Endogenous estrogen metabolites as oxidative stress mediators and endometrial cancer biomarkers

Bukato,

Kostrzewa,

Gammazza

et al. 2024

Cell Commun Signal

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Background Endometrial cancer is the most common gynecologic malignancy found in developed countries. Because therapy can be curative at first, early detection and diagnosis are crucial for successful treatment. Early diagnosis allows patients to avoid radical therapies and offers conservative management options. There are currently no proven biomarkers that predict the risk of disease occurrence, enable early identification or support prognostic evaluation. Consequently, there is increasing interest in discovering sensitive and specific biomarkers for the detection of endometrial cancer using noninvasive approaches. Content Hormonal imbalance caused by unopposed estrogen affects the expression of genes involved in cell proliferation and apoptosis, which can lead to uncontrolled cell growth and carcinogenesis. In addition, due to their ability to cause oxidative stress, estradiol metabolites have both carcinogenic and anticarcinogenic properties. Catechol estrogens are converted to reactive quinones, resulting in oxidative DNA damage that can initiate the carcinogenic process. The molecular anticancer mechanisms are still not fully understood, but it has been established that some estradiol metabolites generate reactive oxygen species and reactive nitrogen species, resulting in nitro-oxidative stress that causes cancer cell cycle arrest or cell death. Therefore, identifying biomarkers that reflect this hormonal imbalance and the presence of endometrial cancer in minimally invasive or noninvasive samples such as blood or urine could significantly improve early detection and treatment outcomes.

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Protective effect of eicosapentaenoic acid against estradiol valerate-induced endometrial hyperplasia via modulation of NF-κB/HIF-1α/VEGF signaling pathway in rats

Abdelzaher

Ibrahim

Hassan

et al. 2023

Chemico-Biological Interactions

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The relationship between oxidative stress markers and endometrial hyperplasia: A case-control study

Cited by 6 publications

References 23 publications

Serum Tenascin-C and Alarin Levels Are Associated with Cardiovascular Diseases in Type 2 Diabetes Mellitus

Serum Tenascin-C and Alarin Levels Are Associated with Cardiovascular Diseases in Type 2 Diabetes Mellitus

Endogenous estrogen metabolites as oxidative stress mediators and endometrial cancer biomarkers

Protective effect of eicosapentaenoic acid against estradiol valerate-induced endometrial hyperplasia via modulation of NF-κB/HIF-1α/VEGF signaling pathway in rats

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