The Relationship between Oxidative Stress and Obesity in Prostate Disease

Scavuzzo, Anna; Favilla, Vincenzo; Cimino, Silvia; Madonia, Massimo; Volti, Giovanni Li; Morgia, Giuseppe

doi:10.5301/ru.2012.9206

Cited by 3 publications

(3 citation statements)

References 3 publications

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“…Serenoa repens has been reported to have antioxidant activity (Habib, ); however, the effect we observed could be attributed primarily to its anti‐androgenic effects. It is known that androgen stimulation can increase oxidative stress in the prostate by activation of metabolic pathways, and anti‐androgens can reduce oxidative stress (Scavuzzo et al , ).…”

Section: Discussionmentioning

confidence: 99%

“…IR directly promotes cell proliferation and contractility alterations of the prostate (Vikram et al , ), which has been identified as an independent predictor of LUTS and erectile dysfunction in patients (Russo et al , ). Both, IR and obesity, are related to the production of reactive oxygen species (ROS) and a state of low‐grade inflammation that in turn modifies the secretion of growth factors in prostatic tissue, increasing the size of the gland regardless of androgen stimulation (Ribeiro et al , ; Scavuzzo et al , ). During oxidative stress, there is increased production of nitric oxide (NO) by activation of inducible NO synthase.…”

Section: Introductionmentioning

confidence: 99%

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Effect ofSerenoa Repenson Oxidative Stress, Inflammatory and Growth Factors in Obese Wistar Rats with Benign Prostatic Hyperplasia

et al. 2015

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Serenoa repens has been widely used to treat benign prostatic hyperplasia and lower urinary tract symptoms; however, most of the studies have been conducted in individuals with normal weight and not obese. In this study, the effects of a lipidic extract of S. repens, in markers of oxidative stress, inflammation, and growth factors, in obese rats with testosterone-induced prostatic hyperplasia, were investigated. Total nitrites, malondialdehyde, total glutathione, superoxide dismutase (SOD), and catalase activity were measured; in addition, assays for inflammatory cytokines TNF-α, IL-1β, IL-6 and the growth factors basic fibroblast growth factor (FGFb) and vascular endothelial growth factor (VEGF) were performed. The obese rats had a higher prostate weight compared with controls. S. repens significantly decreased prostate weight, total nitrites, and malondialdehyde; improved total glutathione, SOD, and catalase activity; and significantly reduced inflammatory (TNF-α, IL-1β and IL-6) and growth factors (VEGF and FGFb). S. repens showed high antioxidant and antiinflammatory activity in obese rats, suggesting that their use could be beneficial in the treatment of benign prostatic hyperplasia.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Effect ofSerenoa Repenson Oxidative Stress, Inflammatory and Growth Factors in Obese Wistar Rats with Benign Prostatic Hyperplasia

et al. 2015

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“…In obesity there is development of insulin resistance, which leads to glucose intolerance and other alterations which can lead to the development of metabolic syndrome; this leads to altered reactive oxygen species (ROS) production and a low-grade inflammation status which subsequently alter the production of growth factors in prostatic tissue increasing the size of the gland in a non-androgen dependent mechanism [25,26]. Inflammation plays an important role, since ROS themselves can cause tissue damage, increasing nitric oxide production by activation of the inducible nitric oxide synthase (iNOS).…”

Section: Obesity and Bphmentioning

confidence: 99%

Phytotherapeutical Alternatives for the Treatment of Benign Prostatic Hyperplasia in Obesity

Colado-Velázquez¹,

Mailloux-Salinas²,

Medina-Contreras³

et al. 2014

TOPROCJ

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Benign prostatic hyperplasia is a very common urinary disorder affecting middle-aged men, giving place to lower urinary tract symptoms, which are detrimental to the quality of life. Obesity increases the risk and severity of its symptoms requiring earlier medical interventions for its treatment. Current pharmacotherapy has serious adverse effects that can lead to discontinuation of the treatment. Phytotherapy is an alternative being used in European countries for several years; however, the evidence for its efficacy is contradictory and remains to be clearly defined. It is of transcendental importance to homogenize quality of plant extracts, as well as to test them in specific age groups to obtain evidence whether plant extracts alone or in combination have the potential to serve as the only therapy or as adjuncts with more traditional treatments for BPH. This review also assesses the fact that no clinical trials have been performed in obese patients, despite the direct link between obesity and prostate disease.

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Effects of algerian nettle ( Urtica dioica L.) on benign prostatic hyperplasia and their mechanism of action elucidation: in vivo and in silico approaches

Bougueroua,

Boufadi,

Latreche

et al. 2023

Natural Product Research

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The Relationship between Oxidative Stress and Obesity in Prostate Disease

Cited by 3 publications

References 3 publications

Effect ofSerenoa Repenson Oxidative Stress, Inflammatory and Growth Factors in Obese Wistar Rats with Benign Prostatic Hyperplasia

Effect ofSerenoa Repenson Oxidative Stress, Inflammatory and Growth Factors in Obese Wistar Rats with Benign Prostatic Hyperplasia

Phytotherapeutical Alternatives for the Treatment of Benign Prostatic Hyperplasia in Obesity

Effects of algerian nettle ( Urtica dioica L.) on benign prostatic hyperplasia and their mechanism of action elucidation: in vivo and in silico approaches

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