The main purpose of this study is to examine the relationship between perceived effort-reward fairness, perceived organizational support, affective commitment, and intention to leave. Survey was used as a data collection method in this study. 176 junior and middle level managers working in service industries in the city of Istanbul in Turkey took the survey. Data obtained from surveys was analyzed through the SPSS statistical package software (v.18). Hierarchical regression analysis was employed to test the hypotheses in this study. The results show that perceived organizational support fully mediates the positive relationship between effort-reward fairness, affective commitment, and perceived organizational support while fully mediating the negative relationship between effort-reward fairness and intention to leave.