The relationship between oral‐origin bacteria in the fecal microbiome and albumin–bilirubin grade in patients with hepatitis C

Yamamoto, Keizô; Honda, Takashi; Ito, Takanori; Ishizu, Yoji; Kuzuya, Teiji; Nakamura, Masanao; Miyahara, Ryoji; Ishigami, Masatoshi; Fujishiro, Mitsuhiro

doi:10.1111/jgh.15206

Cited by 6 publications

(10 citation statements)

References 32 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Bilirubin is excreted into the intestine and reduced to urobilinoids and/or urobilinogens by gut bacteria (Fahmy et al, 1972; Koníčková et al, 2012; Vítek et al, 2005; Vítek & Tiribelli, 2020; Yamamoto et al, 2021). Interestingly, we observed the enrichment of gut microbes involved in urobilinogen metabolism in the high‐altitude samples (Figure 3).…”

Section: Resultsmentioning

confidence: 99%

The putatively high‐altitude adaptation of macaque monkeys: Evidence from the fecal metabolome and gut microbiome

Li,

Xia,

Cui

et al. 2023

Evolutionary Applications

View full text Add to dashboard Cite

Animals living in high‐altitude environments, such as the Tibetan Plateau, must face harsh environmental conditions (e.g., hypoxia, cold, and strong UV radiation). These animals' physiological adaptations (e.g., increased red cell production and turnover rate) might also be associated with the gut microbial response. Bilirubin is a component of red blood cell turnover or destruction and is excreted into the intestine and reduced to urobilinoids and/or urobilinogen by gut bacteria. Here, we found that the feces of macaques living in high‐altitude regions look significantly browner (with a high concentration of stercobilin, a component from urobilinoids) than those living in low‐altitude regions. We also found that gut microbes involved in urobilinogen reduction (e.g., beta‐glucuronidase) were enriched in the high‐altitude mammal population compared to the low‐altitude population. Moreover, the spatial–temporal change in gut microbial function was more profound in the low‐altitude macaques than in the high‐altitude population, which might be attributed to profound changes in food resources in the low‐altitude regions. Therefore, we conclude that a high‐altitude environment's stress influences living animals and their symbiotic microbiota.

show abstract

Section: Resultsmentioning

confidence: 99%

The putatively high‐altitude adaptation of macaque monkeys: Evidence from the fecal metabolome and gut microbiome

Li,

Xia,

Cui

et al. 2023

Evolutionary Applications

View full text Add to dashboard Cite

show abstract

“…Besides, oral Treponema denticola , together with Porphyromonas gingivalis and Tannerella forsythia , are known as the “red complex” which have been widely considered essential pathogens in periodontal disease etiology and pathogenesis. A series of animal and human studies have confirmed that the genera Fretibacterium ( Yamamoto et al., 2021 ), Propionibacterium ( Del Chierico et al., 2017 ), Shuttleworthia ( Xie et al., 2016 ), Eggerthia ( Yamamoto et al., 2021 ), and Bulleidia ( Bashiardes et al., 2016 )are prevalent in the oral or gut microbiota with liver disease including nonalcoholic fatty liver disease, hepatocellular carcinoma. These findings could be interpreted by the emerging oral-gut-liver axis that oral microbes could translocate into the gastrointestinal tract, where they would spread to the liver and induce hepatic diseases( Imai et al., 2021 ).…”

Section: Discussionmentioning

confidence: 99%

Ecological shifts of salivary microbiota associated with metabolic-associated fatty liver disease

Wang

Yan²,

Qiao³

et al. 2023

Front. Cell. Infect. Microbiol.

View full text Add to dashboard Cite

IntroductionMetabolic-associated fatty liver disease (MAFLD) is the most common chronic liver disease related to metabolic syndrome. However, ecological shifts in the saliva microbiome in patients with MAFLD remain unknown. This study aimed to investigate the changes to the salivary microbial community in patients with MAFLD and explore the potential function of microbiota.MethodsSalivary microbiomes from ten MAFLD patients and ten healthy participants were analyzed by 16S rRNA amplicon sequencing and bioinformatics analysis. Body composition, plasma enzymes, hormones, and blood lipid profiles were assessed with physical examinations and laboratory tests.ResultsThe salivary microbiome of MAFLD patients was characterized by increased α-diversity and distinct β-diversity clustering compared with control subjects. Linear discriminant analysis effect size analysis showed a total of 44 taxa significantly differed between the two groups. Genera Neisseria, Filifactor, and Capnocytophaga were identified as differentially enriched genera for comparison of the two groups. Co-occurrence networks suggested that the salivary microbiota from MAFLD patients exhibited more intricate and robust interrelationships. The diagnostic model based on the salivary microbiome achieved a good diagnostic power with an area under the curve of 0.82(95% CI: 0.61–1). Redundancy analysis and spearman correlation analysis revealed that clinical variables related to insulin resistance and obesity were strongly associated with the microbial community. Metagenomic predictions based on Phylogenetic Investigation of Communities by Reconstruction of Unobserved States revealed that pathways related to metabolism were more prevalent in the two groups.ConclusionsPatients with MAFLD manifested ecological shifts in the salivary microbiome, and the saliva microbiome-based diagnostic model provides a promising approach for auxiliary MAFLD diagnosis.

show abstract

“…Among the three age groups, differences in significantly changed OTUs and functional pathways in response to PMA treatment were also observed. For these OTUs, previous studies showed that Selenomonas noxia in saliva was associated with refractory periodontitis [ 39 ] and hepatitis C [ 40 ], while Capnocytophaga granulosa was associated with Papillon-Lefèvre syndrome [ 41 ], but the associations of Peptostreptococcaceae_[XI][G-5]_bacterium_HMT_493 , Ottowia sp._HMT_894 , Treponema sp._HMT_238 , Lachnospiraceae_[G-2] bacterium HMT 096 and some other bacteria with diseases were still not clear. Some of these microbes might always come up in a dead form in saliva samples, resulting in a potential bias in analysis of the pathogenic process in the circumstances of diseases.…”

Section: Discussionmentioning

confidence: 99%

The effects of removing dead bacteria by propidium monoazide on the profile of salivary microbiome

et al. 2021

View full text Add to dashboard Cite

Background Oral microbiome played an important role in maintaining healthy state and might exhibit certain changes under circumstances of diseases. However, current microbiological research using sequencing techniques did not regard dead bacteria as a separate part, causing findings based on subsequent analyses on dynamic equilibrium and functional pathways of microbes somewhat questionable. Since treatment by propidium monoazide (PMA) was able to remove dead bacteria effectively, it would be worth studying how the sequencing results after PMA treatment differed from those focusing on the whole microbiota. Methods Unstimulated whole saliva samples were obtained from 18 healthy people from 3 age groups (children, adults, and the elderly). After removal of dead bacteria by propidium monoazide (PMA), changes in the profile of salivary microbiome were detected using 16S rRNA sequencing technology, and differences among age groups were compared subsequently. Results Dead bacteria accounted for nearly a half of the whole bacteria flora in saliva, while freezing had little effect on the proportion of deaths. After treatment with PMA, the numbers of OTUs reduced by 4.4–14.2%, while the Shannon diversity indices decreased significantly (P < 0.01). Only 35.2% of positive and 6.1% of negative correlations were found to be shared by the whole microbiota and that with dead bacteria removed. Differences in significantly changed OTUs and functional pathways among different age groups were also observed between the group of PMA and the control. Conclusions It was necessary to take the influence of living state of bacteria into account in analytic studies of salivary microbiome.

show abstract

The relationship between oral‐origin bacteria in the fecal microbiome and albumin–bilirubin grade in patients with hepatitis C

Cited by 6 publications

References 32 publications

The putatively high‐altitude adaptation of macaque monkeys: Evidence from the fecal metabolome and gut microbiome

The putatively high‐altitude adaptation of macaque monkeys: Evidence from the fecal metabolome and gut microbiome

Ecological shifts of salivary microbiota associated with metabolic-associated fatty liver disease

The effects of removing dead bacteria by propidium monoazide on the profile of salivary microbiome

Contact Info

Product

Resources

About