Background and Purpose: Breast milk (mother's milk) is the most natural and valuable nutrient that can be provided easily and comfortably for the infant. Although breast-feeding at the beginning is often done without any problems, the continuation of that, especially the exclusive form of mother's milk, is underestimated in many cases by some factors. Studies aimed at identifying effective factors that can be useful in planning for breastfeeding promotion. Therefore, considering this important issue made the researcher carry out this study with the purpose of identifying the factors affecting the lack of continuity of breastfeeding in mothers based on review of literature and experts standpoints in this regard. Methodology: The present studies under consideration were conducted between 2001 and 2018. These were searched using the exclusive keywords. Mag Iran, SID, Med lib, were examined and data were analyzed by using the meta-analysis method (random effect model). Findings: About 30 articles were identified and examined regarding the effective factors that affected the continuation of successful breastfeeding in infants aged between 0 and 6 months. Finally, a variety of factors influencing the lack of continuous breastfeeding have been classified and discussed in order of maternal, neonatal and environmental factors(in order of effect). Conclusion: In order to investigate the factors effecting breastfeeding continuity by mothers, all nurses must take steps to promote breast-feeding and spread awareness regarding the benefit of breast feeding for children along with recommending avoidance of unnecessary cesarean deliveries, advertisements about the benefits of normal vaginal delivery (NVD) for mother and infant, as well as training for breast-feeding and encouraging it during pregnancy and postpartum, especially in mothers with cesarean deliveries.