The relationship between objective physical activity and change in cognitive function

Sewell, Kelsey R; Rainey‐Smith, Stephanie R.; Peiffer, Jeremiah J.; Sohrabi, Hamid R.; Taddei, Kevin; Ames, David; Maruff, Paul; Masters, Colin L.; Rowe, Christopher C.; Martins, Ralph N.; Erickson, Kirk I.; Brown, Belinda M.

doi:10.1002/alz.12950

Cited by 4 publications

(3 citation statements)

References 53 publications

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“…Further research is required to determine the optimal type of exercise or combination of them for achieving maximum benefits [ 44 ]. Other factors such as duration, intensity, frequency [ 45 ], gender [ 46 ], age, and baseline cognitive function [ 35 ] also influenced the effects of exercise on the hippocampus’s function. Therefore, more research should be conducted to identify personalised exercise intervention programs that are applicable to different populations to maximise hippocampal function improvement [ 47 , 48 ].…”

Section: Discussionmentioning

confidence: 99%

Knowledge mapping of trends and hotspots in the field of exercise and cognition research over the past decade

Zhu,

Hu,

Luo

et al. 2024

Aging Clin Exp Res

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Exercise elicits a wide range of physiological responses in mammalian tissues that enhance a broad range of functions, particularly in improving cognitive performance. However, the field lacks a comprehensive bibliometric analysis that clarifies its knowledge structure and research hotspots. This study aims to address this gap and map the research landscape regarding the role of exercise in cognitive function enhancement. Firstly, the frequencies and co-occurrence of keywords were analysed to identify six main clusters: aging, cognitive impairment, rehabilitation, obesity, fatigue, and hippocampus. Secondly, reference timeline co-citation analysis revealed that hippocampus and aging were the major bursts with high intensity and long attention span while children had recently emerged as a topical subject. Finally, the evolution of themes from 2012 to 2022 was analysed, and found that older adults had been the leading research theme for exercise affecting cognition. Childhood obesity was an emerging theme that attracted increasing research attention in recent years while the hippocampus research theme expanded rapidly during the decade but remained a niche topic with less relevance to others. This research identified and summarised research priorities and evolutionary trends in exercise to improve cognition by constructing knowledge networks through visual analysis. It provides researchers with a comprehensive insight into the current state of the field to facilitate further research.

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Section: Discussionmentioning

confidence: 99%

Knowledge mapping of trends and hotspots in the field of exercise and cognition research over the past decade

Zhu,

Hu,

Luo

et al. 2024

Aging Clin Exp Res

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“…1 Consistent evidence from observational research demonstrates that a higher volume of habitual physical activity (any bodily movement resulting in energy expenditure) is associated with better cognitive function and reduced dementia risk. 2,3 Exercise is a structured or planned form of physical activity, 4 the evidence for exercise interventions to modify cognitive function has been inconclusive and less consistent, compared to the observational physical activity literature. 5 Reviews of randomized clinical trials for exercise-induced cognitive change produce varying levels of support.…”

Section: Introductionmentioning

confidence: 99%

The influence of baseline sleep on exercise‐induced cognitive change in cognitively unimpaired older adults: A randomised clinical trial

Sewell,

Rainey‐Smith,

Peiffer

et al. 2023

Int J Geriat Psychiatry

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ObjectivesObservational studies consistently demonstrate that physical activity is associated with elevated cognitive function, however, there remains significant heterogeneity in cognitive outcomes from randomized exercise interventions. Individual variation in sleep behaviours may be a source of variability in the effectiveness of exercise‐induced cognitive change, however this has not yet been investigated. The current study aimed to (1) investigate the influence of a 6‐month exercise intervention on sleep, assessed pre‐ and post‐intervention and, (2) investigate whether baseline sleep measures moderate exercise‐induced cognitive changes.MethodsWe utilised data from the Intense Physical Activity and Cognition (IPAC) study (n = 89), a 6‐month moderate intensity and high intensity exercise intervention, in cognitively unimpaired community‐dwelling older adults aged 60–80 (68.76 ± 5.32). Exercise was supervised and completed on a stationary exercise bicycle, and cognitive function was measured using a comprehensive neuropsychological battery administered pre‐ and post‐intervention. Sleep was measured using the Pittsburgh sleep quality index. There was no effect of the exercise intervention on any sleep outcomes from pre‐ to post‐intervention.ResultsThere was a significant moderating effect of baseline sleep efficiency on both episodic memory and global cognition within the moderate intensity exercise group, such that those with poorer sleep efficiency at baseline showed greater exercise‐induced improvements in episodic memory.ConclusionsThese results suggest that those with poorer sleep may have the greatest exercise‐induced cognitive benefits and that baseline sleep behaviours may be an important source of heterogeneity in previous exercise interventions targeting cognitive outcomes.

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“…There is a well-established link between habitual physical activity (bodily movement resulting in energy expenditure; Caspersen et al, 1985 ) and preservation of cognition in aging ( Sofi et al, 2011 ; Blondell et al, 2014 ; Yoneda et al, 2021 ; Sewell et al, 2023a ). However, evidence for the efficacy of exercise (i.e., structured/planned physical activity) interventions to improve cognitive function in older adults is inconsistent ( Sink et al, 2015 ; Young et al, 2015 ).…”

Section: Introductionmentioning

confidence: 99%

The effect of acute exercise on objectively measured sleep and cognition in older adults

Sewell,

Smith,

Rainey-Smith

et al. 2023

Front. Psychol.

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BackgroundExercise can improve cognition in aging, however it is unclear how exercise influences cognition, and sleep may partially explain this association. The current study aimed to investigate whether objectively measured sleep mediates the effect of an acute exercise intervention on cognition in older adults.MethodsParticipants were 30 cognitively unimpaired, physically active older adults (69.2 ± 4.3 years) with poor sleep (determined via self-report). After a triple baseline cognitive assessment to account for any natural fluctuation in cognitive performance, participants completed either a single bout of 20-minutes of high intensity exercise on a cycle ergometer, or a control condition, in a cross-over trial design. Cognition was measured immediately post-intervention and the following day, and sleep (total sleep time, sleep onset latency, sleep efficiency, % of rapid eye movement sleep, light sleep and deep sleep) was characterized using WatchPAT™ at baseline (5 nights) and measured for one night after both exercise and control conditions.ResultsResults showed no effect of the exercise intervention on cognition immediately post-intervention, nor an effect of acute exercise on any sleep variable. There was no mediating effect of sleep on associations between exercise and cognition. However, a change from baseline to post-intervention in light sleep and deep sleep did predict change in episodic memory at the ~24 h post-intervention cognitive assessment, regardless of intervention condition.DiscussionThere was no effect of acute high intensity exercise on sleep or cognition in the current study. However, results suggest that associations between sleep and cognition may exist independently of exercise in our sample. Further research is required, and such studies may aid in informing the most effective lifestyle interventions for cognitive health.

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The relationship between objective physical activity and change in cognitive function

Cited by 4 publications

References 53 publications

Knowledge mapping of trends and hotspots in the field of exercise and cognition research over the past decade

Knowledge mapping of trends and hotspots in the field of exercise and cognition research over the past decade

The influence of baseline sleep on exercise‐induced cognitive change in cognitively unimpaired older adults: A randomised clinical trial

The effect of acute exercise on objectively measured sleep and cognition in older adults

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