The relationship between obesity and other medical comorbidities

Afolabi, Hafeez Abiola; Zakariya, Zaidi bin; Shokri, Amran Ahmed; Hasim, M.; Vinayak, Rajkumar; Afolabi-Owolabi, Oluwafunke Toyin; Elesho, Rashidat Folashade

doi:10.1016/j.obmed.2019.100164

Cited by 33 publications

(25 citation statements)

References 26 publications

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“…Moreover, studies show that a large number of obese people are likely to develop more virulent viral strains, extend the spread of the virus across the entire population, and eventually increase the overall death rate of an influenza pandemic [ 12 ]. Obesity has also been correlated with certain co-morbidities that are no less dangerous than obesity itself, such as type 2 diabetes mellitus, essential hypertension, coronary artery diseases, atherosclerosis, osteoarthritis, and stroke [ 13 ]. Sattar et al [ 14 ] noted that obesity enhances multiple cardiovascular risk factors, premature cardiovascular disease development, and adverse cardiorenal effects.…”

Section: Introductionmentioning

confidence: 99%

Factors Associated with Increased Morbidity and Mortality of Obese and Overweight COVID-19 Patients

Beshbishy

Hetta

Hussein

et al. 2020

Biology

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Overweight and obesity are defined as an unnecessary accumulation of fat, which poses a risk to health. It is a well-identified risk factor for increased mortality due to heightened rates of heart disease, certain cancers, musculoskeletal disorders, and bacterial, protozoan and viral infections. The increasing prevalence of obesity is of concern, as conventional pathogenesis may indeed be increased in obese hosts rather than healthy hosts, especially during this COVID-19 pandemic. COVID-19 is a new disease and we do not have the luxury of cumulative data. Obesity activates the development of gene induced hypoxia and adipogenesis in obese animals. Several factors can influence obesity, for example, stress can increase the body weight by allowing people to consume high amounts of food with a higher propensity to consume palatable food. Obesity is a risk factor for the development of immune-mediated and some inflammatory-mediated diseases, including atherosclerosis and psoriasis, leading to a dampened immune response to infectious agents, leading to weaker post-infection impacts. Moreover, the obese host creates a special microenvironment for disease pathogenesis, marked by persistent low-grade inflammation. Therefore, it is advisable to sustain healthy eating habits by increasing the consumption of various plant-based and low-fat foods to protect our bodies and decrease the risk of infectious diseases, especially COVID-19.

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Section: Introductionmentioning

confidence: 99%

Factors Associated with Increased Morbidity and Mortality of Obese and Overweight COVID-19 Patients

Beshbishy

Hetta

Hussein

et al. 2020

Biology

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“…Cancer is regarded as a chronic illness that gradually causes a significant decrease in the strength of the immune system, thereby reducing the individual capability to ward off infections (17) . A higher rate of severe outcomes and death were reported among the cancer patients with hematologic cancer (which included patients with lymphoma, myeloma, and leukaemia) thus recording the highest figure, followed by patients with lung cancer.…”

Section: Discussionmentioning

confidence: 99%

A Mini Review on Covid-19 Infection and Severe Outcome on Cancer Patient

Zaidi Zakaria,

Sameer B. Al-Mhanna,

Hafeez A. Afolabi

et al. 2021

Indian Journal of Forensic Medicine & Toxicology

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Introduction December 2019, the world witness a new strand of pathogen known as coronavirus-2 (SARS-CoV-2), later recognized as the novel coronavirus disease . By April 1 st 2020, the confirmed cases were over 800,000 around the world with over 40,000 fatalities. Individuals with cancer are more vulnerable to COVID-19 impact because of compromised health-status.Methods A comprehensive search method was applied by searching the google scholar using the keywords to select eligible studies to be included in the review ResultsThe findings showed that patients with cancer, especially thoracic malignancies that were infected with COVID-19 infection during the hospital stay developed severe cardiorespiratory symptoms that warranted use of a mechanical ventilator. The cancer patients with COVID-19 had increased rate of hospitalization and a poor outcome as well as a higher risk of mortality when compared to healthy individuals. It is recommended that cancer patients taking anti-tumour drugs should undergo early screening for COVID-19 because the anti-tumour drugs also suppress the immune system. Hence, their dosage should be regulated appropriately in case of COVID-19 co-infection. Conclusion.In risk-mitigation pandemic scenario in COVID-19 period, efforts should be made not to compromise the prognosis of cancer in these patients by adhering to treatment guideline.

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“…The consequences of obesity exceed the impacts of smoking or problem drinking in these risk areas and have been shown to exacerbate the risk of other chronic health conditions, thereby diminishing the overall quality of individuals who are obese [20] . The increased risk of developing type 2 diabetes as obesity increases has been shown by multiple studies [19,21,22] . In addition, there is a correlation between obesity and the development of a number of cancers, including breast, ovarian, colorectal, oesophageal, kidney, pancreatic, prostate, and endometrial cancers [22,23] .…”

Section: Obesity Co-morbiditiesmentioning

confidence: 96%

“…In addition, there is a correlation between obesity and the development of a number of cancers, including breast, ovarian, colorectal, oesophageal, kidney, pancreatic, prostate, and endometrial cancers [22,23] . Obesity also increases the likelihood that individuals will experience strokes, hypertension, dyslipidemia, coronary artery disease, congestive heart failure, and pulmonary embolisms [19,21,24] . Moreover, there is an established link between obesity or excessive weight gain and conditions such as chronic back pain, gallbladder disease, osteoarthritis, nonalcoholic liver disease, and asthma [19,25] .…”

Section: Obesity Co-morbiditiesmentioning

confidence: 99%