The Relationship between Nutritional Parameters and Thrombosis Risk in Cancer Patients

Sari, Merve; Ilhan, Yusuf; Göksu, Sema Sezgin; Köstek, Osman; Tatlı, Ali Murat; Çoşkun, Hasan Şenol

doi:10.1080/01635581.2021.1952631

Cited by 5 publications

(4 citation statements)

References 21 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…However, the study suggested that most of the mortality risk in patients with celiac disease was due to increased cardiovascular mortality and the risk of non-Hodgkin lymphoma [ 22 ]. The presence of various micronutrient deficiencies has also been linked to mortality in hospitalized patients and patients undergoing major surgeries [ 23 ]. Malnutrition may also increase mortality through other mechanisms, such as hypoglycemia and hypothermia [ 23 , 24 ].…”

Section: Discussionmentioning

confidence: 99%

“…The presence of various micronutrient deficiencies has also been linked to mortality in hospitalized patients and patients undergoing major surgeries [ 23 ]. Malnutrition may also increase mortality through other mechanisms, such as hypoglycemia and hypothermia [ 23 , 24 ]. Patients with malnutrition who are unable to tolerate oral feeding should receive an alternative form of enteral nutrition to improve outcomes.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Prevalence and Impact of Malnutrition in Hospitalizations Among Celiac Diseases: A Nationwide Analysis

Bains,

Kalra,

Singh

et al. 2023

Cureus

View full text Add to dashboard Cite

Background/Aims: Celiac disease (CD) is a T-cell-mediated gluten sensitivity that results in villous atrophy in the small intestine, leading to chronic malabsorption. Patients with celiac disease are prone to malnutrition. We assessed the impact of malnutrition on in-hospital outcomes in patients with CD. Materials and methods: Patients with a primary discharge diagnosis of CD between January 2016 and December 2019 were included in the National Inpatient Sample Database. Data were collected on patient demographics, hospital characteristics, the Charlson Comorbidity Index (CCI), and concomitant comorbidities. The association between malnutrition and outcomes, including mortality, deep vein thrombosis (DVT), pulmonary embolism (PE), sepsis, acute kidney injury (AKI), length of stay (LOS), and total hospitalization charges (THC), was analyzed using the multivariate regression model. Results: A total of 187310 patients with CD were included in the analysis. Patients with CD and malnutrition had a higher risk of mortality (adjusted odds ratio [aOR], 2.08; p<0.001), AKI (aOR=1.18, p=0.003), and DVT (aOR=1.53; p<0.001) compared to patients with CD without malnutrition. No significant difference was noted in the rates of sepsis and PE. Patients with malnutrition also had a prolonged LOS (2.89 days; p<0.001) and higher THC ($22252.18; p<0.001) compared to patients without malnutrition. Discussion: Patients with CD and malnutrition are at high risk of worse outcomes. Early identification of malnutrition in CD can help prevent morbidity and mortality. Even strict adherence to a gluten-free diet has been associated with malnutrition. Further studies identifying factors associated with malnutrition in CD and the impact of interventions to prevent and treat malnutrition are encouraged.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Prevalence and Impact of Malnutrition in Hospitalizations Among Celiac Diseases: A Nationwide Analysis

Bains,

Kalra,

Singh

et al. 2023

Cureus

View full text Add to dashboard Cite

show abstract

“…We found a significantly higher proportion of patients with cancer who developed PE had concurrent malnutrition, which supports evidence from previous observations that there was a significant relationship between the thrombosis risk and nutritional parameters. 18 Comprehensive assessment of nutritional status and subsequent optimisation of cancer patients is critical.…”

Section: Discussionmentioning

confidence: 99%

Effect of malnutrition on outcomes of hospitalisations for acute pulmonary embolism: a national inpatient database study

Li,

Lio,

et al. 2023

BMJNPH

View full text Add to dashboard Cite

BackgroundTo evaluate the occurrence of malnutrition in pulmonary embolism (PE)-related hospitalisations and assess the impact of malnutrition on the outcomes of patients with PE.MethodsA retrospective observational study using data extracted from the Nationwide Inpatient Sample from 2016 to 2018. Hospitalisations with a principal diagnosis of PE were obtained using International Classification of Diseases, Tenth Revision codes and divided into groups based on a secondary diagnosis of malnutrition.ResultsOf 563 135 PE hospitalisations, 30 495 (5.4%) had malnutrition. PE patients with malnutrition were older (mean age±SD, 69.1±14.5 vs 62.3±16.6, p<0.001) and with higher Charlson Comorbidity Index score (3 to 5, 24.8% vs 12.9%, p<0.001). Concurrent malnutrition was associated with higher adjusted OR (aOR) of in-hospital mortality (aOR 2.43, 95% CI 2.18 to 2.70, p<0.001), acute kidney injury (aOR 1.56, 95% CI 1.45 to 1.67, p<0.001), sepsis (aOR 4.37, 95% CI 3.79 to 5.03, p<0.001), shock (aOR 2.52, 95% CI 2.25 to 2.81, p<0.001), acidosis (aOR 2.55, 95% CI 2.34 to 2.77, p<0.001) and mechanical ventilation (aOR 2.95, 95% CI 2.61 to 3.33, p<0.001). Patients with PE and malnutrition had an increased mean length of stay (adjusted difference 3.39 days, 95% CI 3.14 to 3.65, p<0.001), hospital charges (adjusted difference US$34 802.11, 95% CI US$31 005.01 to US$38 599.22, p<0.001) and costs (adjusted difference US$8 332.01, 95% CI US$7489.09 to US$9174.94, p<0.001).ConclusionConcurrent PE and malnutrition were associated with worse outcomes. The study highlights the importance of identifying malnutrition in patients with PE to improve outcomes and reduce healthcare utilisation.

show abstract

“…Malnutrition in itself is a known risk factor for DVT and PE in patients with gastrointestinal conditions [27,28]. Studies have shown a statistically significant relationship between the risk of thrombosis and nutritional indices such as BMI, weight, and waist circumference [29]. The reasons for these associations are unclear; however, multiple hypotheses have been postulated.…”

Section: Discussionmentioning

confidence: 99%

The Effects of Malnutrition on Inpatient Outcomes in Patients With Gastroparesis: A Nationwide Analysis

Patel,

Bains,

Kalra

et al. 2023

Cureus

View full text Add to dashboard Cite

IntroductionGastroparesis (GP) is a chronic debilitating gastric motility disorder defined as delayed emptying of the stomach content without mechanical obstruction. It can result in nutritional deficiencies, leading to poor overall outcomes. We assessed the impact of malnutrition on in-hospital outcomes in patients with gastroparesis. MethodsPatients with a primary discharge diagnosis of GP between January 2016 and December 2019 were included in the National Inpatient Sample (NIS) database. Data on patient demographics, hospital characteristics, the Charlson Comorbidity Index (CCI), and the etiology of gastroparesis were collected. The association between malnutrition and outcomes, including mortality, deep vein thrombosis (DVT), pulmonary embolism (PE), sepsis, acute kidney injury (AKI), length of stay (LOS), and total hospitalization charges (THC), were analyzed using the multivariate regression model. ResultsA total of 182,580 patients with gastroparesis were included in the analysis. Patients with gastroparesis and malnutrition had a higher risk of mortality (adjusted odds ratio {aOR}, 3.29; p<0.001), sepsis (aOR, 0.43; p<0.001), DVT (aOR, 2.34; p<0.001), and PE (aOR, 2.68; p<0.001) compared to patients with gastroparesis without malnutrition. No significant difference was noted in the rates of AKI. Patients with malnutrition also had a prolonged LOS (2.96 days; p<0.001) and higher THC ($22,890; p<0.001) compared to patients without malnutrition. ConclusionGastroparesis patients with malnutrition are at a greater risk of worse outcomes than those without malnutrition. The early identification of malnutrition in gastroparesis patients can predict morbidity and mortality and assist in risk stratification to enhance outcomes. Further studies are encouraged to identify factors associated with malnutrition in gastroparesis and the impact of interventions to prevent and treat malnutrition.

show abstract

The Relationship between Nutritional Parameters and Thrombosis Risk in Cancer Patients

Cited by 5 publications

References 21 publications

Prevalence and Impact of Malnutrition in Hospitalizations Among Celiac Diseases: A Nationwide Analysis

Prevalence and Impact of Malnutrition in Hospitalizations Among Celiac Diseases: A Nationwide Analysis

Effect of malnutrition on outcomes of hospitalisations for acute pulmonary embolism: a national inpatient database study

The Effects of Malnutrition on Inpatient Outcomes in Patients With Gastroparesis: A Nationwide Analysis

Contact Info

Product

Resources

About