“…IFs are divided into six classes based on their sequence homologies, and in mammalian neurons, a diverse set of IFs can be found, including synemin, peripherin, vimentin, nestin, α-internexin and neurofilaments (NFs). Abnormal accumulations of NFs is found in various neurological diseases such as Parkinson's disease (PD), amyotrophic lateral sclerosis (ALS), infantile spinal muscular atrophy (SMA), Alzheimer's disease (AD), Charcot-Marie-tooth (CMT) disease, Giant axonal neuropathy (GAN) and hereditary sensorymotor neuropathy (HSMN); while many of the aforementioned IFs (specifically peripherin and αinternexin) are known to be central components of NFs [1][2][3] . IFs act as a molecular scaffold and regulate intracellular positioning of nucleus and organelles providing integrity to cells and tissues 4 .…”