The relationship between nerve conduction studies and neuropathic pain in sciatic nerve injury due to intramuscular injection

Fidancı, Halit; Öztürk, İlker

doi:10.3344/kjp.2021.34.1.124

Cited by 6 publications

(4 citation statements)

References 32 publications

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“…Therefore, our study reported that moderate hot compression starting a week after the injury can effectively attenuate the infiltration of inflammatory factors in the affected area, which implies that periodic and continuous hot compression promotes vasoconstriction, and blood circulation contributes to nerve acceleration to the recovery phase. Furthermore, a recent study reported that a physical squeezing-induced nerve injury model produced large changes in the CMAP amplitude prior to large changes in the conduction velocity ( Stecker et al, 2008 ; Fidancı and Öztürk, 2021 ). Therefore, we used CMAP electrophysiological testing to evaluate the therapeutic effects of hot compress treatment in the CCI model.…”

Section: Discussionmentioning

confidence: 99%

Ameliorative Potential of Hot Compress on Sciatic Nerve Pain in Chronic Constriction Injury-Induced Rat Model

Chan

Tsai

Chiang

et al. 2022

Front. Synaptic Neurosci.

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Hot compress modalities are used to ameliorate pain despite prevalent confusion about which modality should be used and when. Most recommendations for hot compresses are based on empirical experience, with limited evidence to support its efficacy. To obtain insight into the nerve transmission mechanism of hot compresses and to identify the nerve injury marker proteins specifically associated with sciatic nerve pain, we established a rat model of chronic constriction injury (CCI) and performed mechanical allodynia, electrophysiology, and histopathological analysis. All CCI rats exhibited geometric representation of the affected hind paw, which indicated a hyper-impact on both mechanical gait and asymmetry of gait on day 28. The CCI model after 28 days of surgery significantly reduced compound muscle action potential (CMAP) amplitude, but also significantly reduced latency. Administration of hot compress for 3 weeks (heated at 40–42°C, cycle of 40 min, and rest for 20 min, three cycles each time, three times per week) significantly increased the paw withdrawal thresholds in response to stimulation by Von Frey fibers and reversed the CCI-induced reduced sciatic functional index (SFI) scores. Hot compress treatment in the CCI model improved CMAP amplitude and latency. The S100 protein expression level in the CCI+Hot compression group was 1.5-fold higher than in the CCI group; it dramatically reduced inflammation, such as tumor necrosis factor alpha and CD68 expression in nerve injury sites. Synaptophysin (Syn) expression in the CCI+Hot compression group was less than threefold in the CCI group at both nerve injury sites and brain (somatosensory cortex and hippocampus). This finding indicates that local nerve damage and inflammation cause significant alterations in the sensorimotor strip, and hot compress treatment could significantly ameliorate sciatic nerve pain by attenuating Syn and inflammatory factors from local pathological nerves to the brain. This study determines the potential efficacy and safety of hot compress, and may have important implications for its widespread use in sciatic nerve pain treatment.

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Section: Discussionmentioning

confidence: 99%

Ameliorative Potential of Hot Compress on Sciatic Nerve Pain in Chronic Constriction Injury-Induced Rat Model

Chan

Tsai

Chiang

et al. 2022

Front. Synaptic Neurosci.

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“…5,41,73 Pain was reported to have a high incidence in neuropathic patients showing abnormalities in nerve conduction studies, although these tests only provide information on impairment of Ab fibers. 31,33 Commonly used medications, such as gabapentin, lamotrigine, or pyridoxine plus pyridostigmine, showed low efficacy against neuropathic pain in random clinical trials. 55,62,89 Previously, several attempts have been performed to treat or prevent CIN with various neuroprotective drugs, but most of them are either ineffective or cause neurological side effects.…”

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Broad-spectrum neuroprotection exerted by DDD-028 in a mouse model of chemotherapy-induced neuropathy

Lucarini

Micheli

Rajagopalan³

et al. 2023

Pain

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Neurotoxicity of chemotherapeutics involves peculiar alterations in the structure and function, including abnormal nerve signal transmission, of both the peripheral and central nervous system. The lack of effective pharmacological approaches to prevent chemotherapy-induced neurotoxicity necessitates the identification of innovative therapies. Recent evidence suggests that repeated treatment with the pentacyclic pyridoindole derivative DDD-028 can exert both pain-relieving and glial modulatory effects in mice with paclitaxel-induced neuropathy. This work is aimed at assessing whether DDD-028 is a disease-modifying agent by protecting the peripheral nervous tissues from chemotherapy-induced damage. Neuropathy was induced in animals by paclitaxel injection (2.0 mg kg−1 i.p). DDD-028 (10 mg kg−1) and the reference drug, pregabalin (30 mg kg−1), were administered per os daily starting concomitantly with the first injection of paclitaxel and continuing 10 days after the end of paclitaxel treatment. The behavioural tests confirmed the antihyperalgesic efficacy of DDD-028 on paclitaxel-induced neuropathic pain. Furthermore, the electrophysiological analysis revealed the capacity of DDD-028 to restore near-normal sensory nerve conduction in paclitaxel-treated animals. Histopathology evidence indicated that DDD-028 was able to counteract effectively paclitaxel-induced peripheral neurotoxicity by protecting against the loss of intraepidermal nerve fibers, restoring physiological levels of neurofilament in nerve tissue and plasma, and preventing morphological alterations occurring in the sciatic nerves and dorsal root ganglia. Overall, DDD-028 is more effective than pregabalin in preventing chemotherapy-induced neurotoxicity. Thus, based on its potent antihyperalgesic and neuroprotective efficacy, DDD-028 seems to be a viable prophylactic medication to limit the development of neuropathies consequent to chemotherapy.

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“…Successful neurorrhaphy is not a matter of simple surgical judgement regarding the apparent clinical alignment of the proximal and distal ends of the nerve, or what can be considered a tension free suture, it must be based on sound measures. One of the well-established reliable methods is the use of electromyography measurements to detect nerve conduction as, latency in conduction in milliseconds, amplitude of voltage in millivoltages and reaction of degeneration [17][18][19] . Immunohistochemical examination of the repaired segment is another sound prove of nerve regeneration that has been used in many studies [20][21][22] .…”

Section: Introductionmentioning

confidence: 99%

Effect of Low Level Laser Therapy (LLLT) as an adjunct to Platelet Rich Fibrin (PRF) on sciatic nerve regeneration in rat model

Dakrory

Amin

2022

Egyptian Dental Journal

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Peripheral nerve injury (PNI) is a challenging injury in which healing relies on many factors. End-to-end neurorrhaphy (EEN) is the gold standard technique used in management of these injuries. Platelet rich fibrin (PRF) and low level laser therapy (LLLT) have the ability to enhance nerve regeneration after neurorrhaphy. The aim of this study is to evaluate the effect of LLLT as an adjunct to PRF use after end-to-end neurorrhaphy on sciatic nerve regeneration in rat model. Material and methods:This double-blind randomized study was performed on 20 Albino Wistar rats in the animal house of Misr University for Science and Technology. Animals were divided into two groups; group I in which nerve repair was performed using EEN with PRF membrane, in group II the same treatment was performed in addition to intraoperative application of LLLT diode laser. Within each group, animals were divided into two subgroups where rats were sacrificed after one and three weeks follow-up period. Assessment was performed using electromyography measurements and area percent evaluation of S100 protein immunostain at one and three weeks follow-up periods.Results: Comparison showed that electromyography measurements improved in group II more than group I with significant difference in the first week follow-up period. At three weeks follow-up period group II showed enhanced values than group I but with no significance. Histologic examination showed more enhanced regeneration with group II at both follow-up periods with significant difference. Conclusion:Application of LLLT enhances peripheral nerve regeneration of sciatic nerve in rat model (3172)

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The relationship between nerve conduction studies and neuropathic pain in sciatic nerve injury due to intramuscular injection

Cited by 6 publications

References 32 publications

Ameliorative Potential of Hot Compress on Sciatic Nerve Pain in Chronic Constriction Injury-Induced Rat Model

Ameliorative Potential of Hot Compress on Sciatic Nerve Pain in Chronic Constriction Injury-Induced Rat Model

Broad-spectrum neuroprotection exerted by DDD-028 in a mouse model of chemotherapy-induced neuropathy

Effect of Low Level Laser Therapy (LLLT) as an adjunct to Platelet Rich Fibrin (PRF) on sciatic nerve regeneration in rat model

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