2020
DOI: 10.1016/j.ssmph.2019.100517
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The relationship between neighborhood socioeconomic deprivation and telomere length: The 1999–2002 National Health and Nutrition Examination Survey

Abstract: Socioeconomically disadvantaged neighborhoods have been associated with poor health outcomes. Little is known about the biological mechanism by which deprived neighborhood conditions exert negative influences on health. Data from the 1999–2002 National Health and Nutrition Examination Surveys (NHANES) were used to assess the relationship between neighborhood deprivation index (NDI) and log-transformed leukocyte telomere length (LTL) via multilevel modeling to control for census tract level clustering. Models w… Show more

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Cited by 28 publications
(29 citation statements)
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“…United States Census Bureau data from the 2010 American Community Survey was used to create a Neighborhood Deprivation Index (NDI) for census tracts in Washington, D.C. and Maryland, as previously described ( 25 ). Briefly, key variables were identified via principal axis factoring with oblique rotation (minimum loading score 0.40; minimum eigenvalue 1).…”
Section: Methodsmentioning
confidence: 99%
“…United States Census Bureau data from the 2010 American Community Survey was used to create a Neighborhood Deprivation Index (NDI) for census tracts in Washington, D.C. and Maryland, as previously described ( 25 ). Briefly, key variables were identified via principal axis factoring with oblique rotation (minimum loading score 0.40; minimum eigenvalue 1).…”
Section: Methodsmentioning
confidence: 99%
“…Leukocyte telomere length has been linked to immune cell dysfunction, various chronic diseases ( 60 ), and psychosocial stress [as summarized in ( 61 )]; telomere length has been suggested as a new tool for immunoepigenetics ( 62 ). A recent study from our lab using data from the National Health and Nutrition Examination Survey demonstrated that living in socioeconomically disadvantaged neighborhoods associated with shorter leukocyte telomere length among U.S. adults, indicating the potential impact of adverse neighborhood conditions on immune cells ( 63 ). It is important to note that leukocyte telomere length has also been reported to have inconclusive results for some diseases ( 64 ) and certainly warrants future research as racial/ethnic differences have been shown when comparing telomere length and/or telomere shortening rate of Blacks to those of Whites ( 65 67 ).…”
Section: Markers Of Social Position and The Immune Systemmentioning
confidence: 99%
“…Childhood trauma also increases the risk of respiratory, heart, and metabolic diseases [ 13 ]. Childhood trauma deteriorates health through various mechanisms such as systemic inflammation [ 14 ], reducing telomere length [ 15 , 16 , 17 , 18 ], and DNA methylation [ 19 , 20 , 21 ]. Exposure to childhood trauma also impacts the developing brain [ 22 ].…”
Section: Introductionmentioning
confidence: 99%