The relationship between mucosal histamine and fibrinolytic activity in duodenal ulcer disease

B‐Raf/Rap1 signaling, but not c‐Raf‐1/Ras, induces the histidine decarboxylase promoter inHelicobacter pyloriinfection

“…Expression of the HDC gene is controlled mainly by gastrin binding to the CCK-B (cholecystokinin-B/gastrin) receptor, and MAP kinase pathways are involved in the signaling (4). Enhanced expression of HDC and consecutive increases in gastric acid production have clearly been correlated with gastric inflammation and the development of gastroduodenal ulcers (5).…”

Single nucleotide polymorphisms and haplotypes of histamine N-methyltransferase in patients with gastric ulcer

“…The PCR-RFLP assays that firstly developed in this study will also be applicative for other related population genetics and disease association studies. (20) 0.110 (17) TCCA, TCCT 0.051 (6) 0.078 (12) TCCA, CTCT 0.042 (5) 0.045 (7) CCCT, CCCT 0.008 (1) 0.039 (6) TCCA, CCTT 0.034 (4) 0.032 (5) CCCA, CCCT 0.042 (5) 0.026 (4) CTCA, CCCT 0.025 (3) 0.026 (4) CCCT, CCTT 0.017 (2) 0.019 (3) TCCA, TCTT 0.008 (1) 0.013 (2) CTCA, CTCA 0.008 (1) 0.013 (2) CCCA, CTCA 0.017 (2) 0.006 (1) CCCT, TCCT 0.017 (2) -TCCT, CCTT -0.013 (2) * No significant difference was found between cases and controls in haplotype and haplotype pair frequencies (P > 0.05). …”

“…Previous studies on the HNMT activity in patients with peptic ulcer, however, have given conflicting results, with decreased [7 -9, 14], increased [5], and unchanged [10,11,15] mucosal HNMT activity having been all reported. As the HNMT activity in human tissues is predominantly regulated by inheritance [16,17], it is possible that gene polymorphisms of HNMT might play roles in susceptibility to some histamine-related diseases, such as asthma, allergy, peptic ulcers and neuropsychiatric disorders.…”

“…Histamine, which is a ubiquitous biogenic amine, plays a crucial role in the regulation of gastric acid secretion via both H 2 and H 3 receptors on parietal cells [2 -3], and antagonist for H 2 receptor has already been widely used in the treatment of peptic ulcers. Histamine might also affect gastric defensive factors such as the mucosal blood flow [4,5] and mucin synthesis/secretion [6]. It has been documented that patient with peptic ulcer has distinct gastric mucosal histamine from normal controls [5, 7 -11].…”