The relationship between motor neuron disease and bullous pemphigoid: An English cohort study

Ong, Eugene Liat Hui; Goldacre, Raph; Taghipour, Kathy

doi:10.1016/j.jaad.2013.06.033

Cited by 5 publications

(5 citation statements)

References 5 publications

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“…The previous studies, except the ones considering motor neuron diseases8 and strokes15, have most probably missed this connection because of small study populations or short follow-up time. Still, the 2-fold increased risk of viral meningitis or viral encephalitis following a diagnosis of BP was unexpected.…”

Section: Discussionmentioning

confidence: 99%

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Psychiatric and neurological disorders are associated with bullous pemphigoid – a nationwide Finnish Care Register study

Försti

Jokelainen

Ansakorpi

et al. 2016

Sci Rep

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Bullous pemphigoid (BP) is an autoimmune blistering skin disease with increasing incidence. BP is associated with neurological disorders, but it has not been established, what subtypes of dementia and stroke are associated with BP, and what is the temporal relation between these diseases. Also, the association between BP and psychiatric disorders is controversial. We conducted a retrospective nationwide study, using the Finnish Care Register for Health Care diagnoses between 1987 and 2013. The study population of 4524 BP patients were compared with 66138 patients with basocellular carcinoma (BCC), neurological and psychiatric comorbid disorders were evaluated for both groups, and associations were estimated by Cox regression and logistic regression analyses. The strongest risk of developing BP was found after diagnosis of multiple sclerosis (MS) (OR=5.9, 95% CI 3.9–8.5). Among psychiatric diseases, the corresponding risk was strongest in schizophrenia (OR=2.7, 95% CI 2.0–3.5), and as a novel finding, also personality disorders (OR=2.2, 95% CI 1.3–3.3) preceded BP. In conclusion, many psychiatric disorders, especially schizophrenia, carry heightened risk for BP. Furthermore, several neurological diseases which cause central nervous system inflammation or degeneration were related to BP, and the association was strongest between MS and BP.

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Section: Discussionmentioning

confidence: 99%

“…Several studies have established an association between BP and neurological disorders, especially stroke, dementia and Parkinson’s disease5678. The mechanism behind this association has been suggested to be an autoinflammatory reaction against BP180 or the neuronal isoform of BP230 in the human brain910.…”

mentioning

confidence: 99%

Psychiatric and neurological disorders are associated with bullous pemphigoid – a nationwide Finnish Care Register study

Försti

Jokelainen

Ansakorpi

et al. 2016

Sci Rep

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“…The prevalence and the incidence of neurodegenerative disease have been increasing in recent decades as a result of the aging population (18–20), and the recognition of autoimmune-related dementias is increasing; both of these factors are prompting further investigation of the association between autoimmunity and dementia (21). To better understand the association between BP and neurologic disorders, we conducted a 50-year population-based study on the co-occurrence of neurologic disorders in patients with BP in one Midwestern county.…”

Section: Introductionmentioning

confidence: 99%

A population-based study of the association between bullous pemphigoid and neurologic disorders

Brick

Weaver

Savica

et al. 2014

Journal of the American Academy of Dermatology

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Background Bullous pemphigoid has been reported in association with neurologic disorders. Objective To analyze the association between bullous pemphigoid and neurologic disorders. Methods We retrospectively identified residents of Olmsted County, Minnesota, with a first lifetime diagnosis of bullous pemphigoid between January 1, 1960, and December 31, 2009. Three age- and sex-matched Olmsted County residents without bullous pemphigoid were selected as controls for each patient. We compared history of or development of neurologic disorders (dementia, Alzheimer disease, Parkinson disease, multiple sclerosis, cerebrovascular disease, and seizures) between groups using case-control and cohort designs. Results A total of 87 patients with bullous pemphigoid were identified and matched to 261 controls. The odds of a previous diagnosis of any neurologic disorder or a history of dementia were significantly increased among cases compared with controls (odds ratios: 6.85 (3.00–15.64); P<.001, and 6.75 (2.08–21.92); P=.002, respectively). Both Parkinson disease (hazard ratio, 8.56 (1.55–47.25); P=.01) and any type of neurologic disorder (hazard ratio, 2.02 (1.17–3.49); P=.01) were significantly more likely to develop during follow-up in patients with bullous pemphigoid than in those without bullous pemphigoid. Limitations Small geographic area; retrospective study design. Conclusion Our study confirmed an association of bullous pemphigoid with neurologic disorders, especially dementia and Parkinson disease.

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“…It is a blistering cutaneous disease that is characterized by tension bullae 1–3 . Within the last few decades, neurodegenerative disease prevalence and incidence have increased as the age of the population has increased 4–6 . A number of previous studies have evaluated the positive associations between BP and neurological diseases in elderly populations 7–9 …”

Section: Introductionmentioning

confidence: 99%

“…[1][2][3] Within the last few decades, neurodegenerative disease prevalence and incidence have increased as the age of the population has increased. [4][5][6] A number of previous studies have evaluated the positive associations between BP and neurological diseases in elderly populations. [7][8][9] BP blister formation is due to the production of autoantibodies reactive with the hemi-desmosome proteins, BP180 and BP230.…”

Section: Introductionmentioning

confidence: 99%

Associations among bullous pemphigoid and various neurological diseases: A systematic review and meta‐analysis

Chen

Lyu

et al. 2022

JEADV Clinical Practice

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Bullous pemphigoid is a common autoimmune bullous skin disease of the elderly. The objective of this meta-analysis was to assess the association of bullous pemphigoid with neurological disease. We conducted a systematic search of three databases, screening for articles with relevant search terms from database inception until August 01, 2020. The Newcastle-Ottawa quality assessment scale was used to evaluate the quality of the retained articles.Random effects models were applied to calculate the pooled odds ratio and confidence intervals. Publication bias was evaluated by funnel plot and Egger's test. A total of 25 studies with 44,726 BP patients were included in this metaanalysis. Patients with BP were significantly more likely to have any neurological disease [odds ratio (OR): 4.

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The relationship between motor neuron disease and bullous pemphigoid: An English cohort study

Cited by 5 publications

References 5 publications

Psychiatric and neurological disorders are associated with bullous pemphigoid – a nationwide Finnish Care Register study

Psychiatric and neurological disorders are associated with bullous pemphigoid – a nationwide Finnish Care Register study

A population-based study of the association between bullous pemphigoid and neurologic disorders

Associations among bullous pemphigoid and various neurological diseases: A systematic review and meta‐analysis

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