The Relationship Between Monocyte Count to High-density Lipoprotein Ratio and Severity of Inflammation in Aggressive Periodontitis: A Retrospective Analysis

Güler, Berceste; Doğan, Ezgi; Onbaşı, Kevser

doi:10.4274/meandros.galenos.2020.41033

Cited by 4 publications

(3 citation statements)

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“…Of particular interest is the physiology of the individual's immune response. The presence of certain periodontal microorganisms initiates immune responses (Bartold and Van Dyke, 2019 ; Güler et al, 2020 ) involving both innate immunity players [such as macrophages, dendritic cells, natural killer (NK) cells, monocytes, neutrophils] as well as adaptive immunity (represented by the concerted action of B and T lymphocytes) resulting in the production and release of pro-inflammatory molecules ([such as interferon (IFN)-γ, interleukin (IL)-17, tumor necrosis factor (TNF), IL-1, IL-6] and associated enzymes—in particular collagenases such as matrix metalloproteinases (MMPs) ( Figures 1A,B ) (Franco et al, 2017 )—(Holmström et al, 2017 ; Nascimento et al, 2017 ; Dahlen et al, 2019 ; Cecoro et al, 2020 ).…”

Section: Biological Aspects Of Periodontal Inflammationmentioning

confidence: 99%

Periodontal Inflammation and Systemic Diseases: An Overview

2021

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Periodontitis is a common inflammatory disease of infectious origins that often evolves into a chronic condition. Aside from its importance as a stomatologic ailment, chronic periodontitis has gained relevance since it has been shown that it can develop into a systemic condition characterized by unresolved hyper-inflammation, disruption of the innate and adaptive immune system, dysbiosis of the oral, gut and other location's microbiota and other system-wide alterations that may cause, coexist or aggravate other health issues associated to elevated morbi-mortality. The relationships between the infectious, immune, inflammatory, and systemic features of periodontitis and its many related diseases are far from being fully understood and are indeed still debated. However, to date, a large body of evidence on the different biological, clinical, and policy-enabling sources of information, is available. The aim of the present work is to summarize many of these sources of information and contextualize them under a systemic inflammation framework that may set the basis to an integral vision, useful for basic, clinical, and therapeutic goals.

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Section: Biological Aspects Of Periodontal Inflammationmentioning

confidence: 99%

Periodontal Inflammation and Systemic Diseases: An Overview

2021

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“…NI NI NI . NI TG > 200; TC > 200; LDL > 130; HDL < 35; VLDL> 40 TC, TG, LDL, HDL OR – High Gao H, 2015 [ 19 ] China Case-control 185/138 Secure 27.91 0.96 40.56 1.00 NI TC, HDL, LDL, TG Mean (SD) Age, gender, smoking, BMI Moderate Golpasand HL, 2014 [ 20 ] Iran Case-control 45/45 Secure 34.74 0.96 46.67 0.91 TC > 220; TG > 200; LDL > 178; HDL < 29 TC, TG, HDL, LDL Mean (SD), Post-OR Age, gender, number of teeth Moderate Güler B, 2020 [ 21 ] Turkey Cross-sectional LagP: 16; GagP: 16 NI 34.79 1.02 25 1.00 NI HDL Mean (SD) – Moderate Hamissi J, 2011 [ 22 ] Iran Case-control 30/30 Secure 35.32 1.04 NI 1.00 NI TC, HDL, LDL, TG Mean (SD) Age, gender Moderate Han SJ, 2019 [ 23 ] Korea Cross-sectional 4997/12007 Insecure 44.61 1.29 50.2 1.28 TC ≥ 240; HDL-C < 40; HDL-C ≥ 60; TG ≥ 200; LDL-C ≥ 160 TC, HDL, LDL, TG OR Adjust 1 Moderate Kalburgi V, 2014 [ …”

Section: Methodsmentioning

confidence: 99%

Exploring the bi-directional relationship between periodontitis and dyslipidemia: a comprehensive systematic review and meta-analysis

Ma,

Zou,

Yang

et al. 2024

BMC Oral Health

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Aim As periodontitis and dyslipidemia are diseases that occur with high incidence, the relationship between them has attracted much attention. Previous studies on these diseases have tended to focus on lipid parameters and periodontitis, we aimed to investigate the relationship between dyslipidemia and periodontitis. Materials and methods A comprehensive search to identify the studies investigating the relationship between dyslipidemia and periodontitis was performed on PubMed, Web of Science and Cochrane Library before the date of August, 2023. Studies were considered eligible if they contained data on abnormal blood lipid parameters and periodontitis. Studies that reported mean differences and 95% confidence intervals or odds ratios were used. Results A total of 73 publications were included in the meta-analysis. Hyper total cholesterol (TC), triglycerides (TGs), low-density lipoprotein (LDL), very low-density lipoprotein (VLDL) and lower high-density lipoprotein (HDL) levels are risk factors for periodontitis. Periodontal disease is a risk factor for high TG and low HDL levels. Three months after periodontal treatment, the levels of TC, TG and HDL were significantly improved, and statin treatment only improved gingival index (GI) levels compared to that of the dietary control. Conclusions The findings reported here suggest that the mutual promotion of periodontitis and dyslipidemia can be confirmed. Non-surgical periodontal therapy may improve lipid abnormalities. It can’t be demonstrated whether systematic application of statins have a better effect on the improvement in periodontal status in patients with dyslipidemia compared to that of the control.

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“…For example, an association has been established between high blood pressure and periodontitis, i.e., patients with previously undetected elevated blood pressure may also suffer from periodontal disease [2]. Certain periodontal microorganisms initiate immune responses [3]; hence apical periodontitis can elevate the inflammatory status of the individual as well as insulin resistance [4]. During pregnancy, the oral cavity is more frequently exposed to gastric acid, which can erode tooth enamel, thus making the teeth more sensitive and more susceptible to dental caries [5].…”

Section: Introductionmentioning

confidence: 99%

Impact of school for future parents and first preventive examination in the first year of life on oral habits

2023

Journal of Clinical Pediatric Dentistry

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Pregnancy is an ideal time to promote the primary prevention of early childhood caries. It is crucial to have a child’s first dental examination in the first year of life. The aim of this study was to find out how the School for future parents and the child’s first dental examination affect children’s oral habits. A specialist pediatric dentist was involved in the implementation of the School for future parents and the courses and on timely care for the good oral health of the child. We examined all one- and two-year-olds whose parents responded positively to a dental examination for their child. During the first examination, we considered attendance at the School, how the parents booked the dental examination, what the child drinks when thirsty, how many times a day they brush their children’s teeth and toothpaste use. During the second examination, we considered what the child drinks when thirsty, how many times a day the parents brush their children’s teeth and toothpaste use. The results showed that participants in the School were more likely to book their children’s first preventive, consultative dental examination (p < 0.001), brush their children’s teeth, and use toothpaste (p < 0.001) than parents who did not attend the school. However, there was no difference between the two groups regarding what parents gave their children to drink when they were thirsty (p = 0.69). In the child’s second year, all the parents used toothpaste, brushed their children’s teeth more often, and their children drank sweet drinks more often than before the first examination (p < 0.001). We have succeeded in raising awareness of good oral habits among parents and children (the frequency of brushing children’s teeth and the using toothpaste), but not changed the behavior in the type of drinking against thirst.

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The Relationship Between Monocyte Count to High-density Lipoprotein Ratio and Severity of Inflammation in Aggressive Periodontitis: A Retrospective Analysis

Cited by 4 publications

References 0 publications

Periodontal Inflammation and Systemic Diseases: An Overview

Periodontal Inflammation and Systemic Diseases: An Overview

Exploring the bi-directional relationship between periodontitis and dyslipidemia: a comprehensive systematic review and meta-analysis

Impact of school for future parents and first preventive examination in the first year of life on oral habits

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