The relationship between maximum isometric strength and intramuscular circulatory occlusion

Barnes, William S.

doi:10.1080/00140138008924748

Cited by 165 publications

(138 citation statements)

References 10 publications

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“…By using only volitional measurements of MVC and sustained isometric exercise, a reduction in FI O 2 was shown to have no significant influence on rate of fatigue development during isolated muscle exercise (5,6). However, the increased intramuscular pressure accompanying sustained isometric exercise causes substantial and sustained ischemia, even in normoxia (4,5). When intermittent isometric exercise of the adductor pollicis muscle was used to cause fatigue, acute hypoxia significantly accelerated the rate of decline of MVC force output (21).…”

Section: Hypoxic Effects On Peripheral Muscle Fatiguementioning

confidence: 99%

Effect of arterial oxygenation on quadriceps fatigability during isolated muscle exercise

Katayama

Amann²,

Pegelow³

et al. 2007

American Journal of Physiology-Regulatory, Integrative and Comp

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.-The effect of various levels of oxygenation on quadriceps muscle fatigability during isolated muscle exercise was assessed in six male subjects. Twitch force (Qtw) was assessed using supramaximal magnetic femoral nerve stimulation. In experiment 1, maximal voluntary contraction (MVC) and Qtw of resting quadriceps muscle were measured in normoxia [inspired O2 fraction (FIO 2 ) ϭ 0.21, percent arterial O2 saturation (Sp O 2 ) ϭ 98.4%, estimated arterial O2 content (CaO 2 ) ϭ 20.8 ml/dl], acute hypoxia (FIO 2 ϭ 0.11, Sp O 2 ϭ 74.6%, CaO 2 ϭ 15.7 ml/dl), and acute hyperoxia (FIO 2 ϭ 1.0, Sp O 2 ϭ 100%, CaO 2 ϭ 22.6 ml/dl). No significant differences were found for MVC and Qtw among the three FIO 2 levels. In experiment 2, the subjects performed three sets of nine, intermittent, isometric, unilateral, submaximal quadriceps contractions (62% MVC followed by 1 MVC in each set) while breathing each FIO 2 . Qtw was assessed before and after exercise, and myoelectrical activity of the vastus lateralis was obtained during exercise. The percent reduction of twitch force (potentiated Qtw) in hypoxia (Ϫ27.0%) was significantly (P Ͻ 0.05) greater than in normoxia (Ϫ21.4%) and hyperoxia (Ϫ19.9%), as were the changes in intratwitch measures of contractile properties. The increase in integrated electromyogram over the course of the nine contractions in hypoxia (15.4%) was higher (P Ͻ 0.05) than in normoxia (7.2%) or hyperoxia (6.7%). These results demonstrate that quadriceps muscle fatigability during isolated muscle exercise is exacerbated in acute hypoxia, and these effects are independent of the relative exercise intensity. hypoxia; magnetic femoral nerve stimulation; hyperoxia ; hypoxemia; quadriceps twitch force WE AND OTHERS HAVE RECENTLY SHOWN that high-intensity whole body exercise to exhaustion caused significant peripheral limb muscle fatigue and that the level of arterial O 2 content (Ca O 2 ) via changes in inspired O 2 fraction (FI O 2 ) is a significant determinant of the rate at which peripheral muscle fatigue is developed during exercise (2,43,46). In these studies, evidence for the effects of Ca O 2 on peripheral fatigue was obtained via measures of quadriceps force output using supramaximal magnetic stimulation obtained pre-vs. postexercise and also by the rate of rise of quadriceps muscle electromyogram (EMG) during the exercise. The latter measurement presumably indicates the rate of motor unit recruitment in response to peripheral fatigue development (2, 46). Given that a changing Ca O 2 induced by breathing various FI O 2 also had significant effects on maximal peak exercise capacity during whole body exercise, the observed effect of changing Ca O 2 on peripheral limb fatigue might be attributed at least in part to changes in relative work intensity (2, 43). Different relative work intensities might be expected to influence the rate of accumulation of muscle metabolites (27) and therefore influence peripheral muscle fatigue.We tested this hypothesis by using isolated submaximal isometric contractions of th...

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Section: Hypoxic Effects On Peripheral Muscle Fatiguementioning

confidence: 99%

Effect of arterial oxygenation on quadriceps fatigability during isolated muscle exercise

Katayama

Amann²,

Pegelow³

et al. 2007

American Journal of Physiology-Regulatory, Integrative and Comp

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show abstract

“…Moreover, intramuscular pressure and the associated degree of blood flow occlusion increase linearly with an increasing intensity of contraction. [19][20][21][22][23][24][25][26][27] It can be postulated that muscular hypertonia, spasticity, and contractures induce a state of relative ischemia.…”

Section: Why Free Radical Scavengers?mentioning

confidence: 99%

“…[18][19][20][21][22][23][24][25][26][27][28][29][30][31][32][33][34][35][36][37] Ischemia/Reperfusion Syndrome An isometric muscle contraction accompanied by an elevation of muscular pressure, consequent upon vascular occlusion, can induce a state of relative ischemia in an extremity. Such elevations compress and may even occlude the arteries if the pressure becomes fairly high.…”

Section: Why Free Radical Scavengers?mentioning

confidence: 99%

Free radical scavengers are more effective than indomethacin in the prevention of experimentally induced heterotopic ossification

Bossche

Maele

Wojtowicz

et al. 2006

Journal Orthopaedic Research

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The pathogenesis of heterotopic ossification is still unclear and the preventive therapies are usually insufficient. The present study was designed to investigate the possible preventive effect of free radical scavengers on the development of experimentally induced heterotopic ossification in a rabbit model and to compare free radical scavengers with indomethacin to determine whether they act synergistically. A standard immobilization-manipulation model was used to induce heterotopical ossification in the hind legs of 40 1-year-old female New Zealand albino rabbits. The animals were divided into four groups and received daily either placebo, a free radical scavenger cocktail [allopurinol and N-acetylcysteine (A/A)], indomethacin or the combination of A/A and indomethacin in a randomized double-blind fashion. Every 4 days an X-ray was taken and the thickness and length of new bone formation was measured at the thigh. A marked statistically significant difference was found between the four groups. In the groups that received A/A, either alone or combined with indomethacin, an inhibition of bone growth, both in thickness and in length was demonstrated. In this experimental model free radical scavengers had a superior inhibitory effect on heterotopic ossification than indomethacin. Free radicals could play an important role in the pathogenesis of heterotopic ossification. ß

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“…Blood flow during rhythmic exercise dramatically changes concomitant with muscle contraction and relaxation (Barcroft and Dornhorst 1949, Barnes 1986, Kagaya and Ogita 1992, Walløe and Wesche 1988. This mechanical disturbance of muscle circulation originates from the anatomical arrangements of muscle fibers and vessels.…”

Section: Introductionmentioning

confidence: 99%

“…In addition, the muscles develop tension during muscle contractions and thereby the elevated intramuscular pressure compresses the capillaries between the fibers (Sjø gaard, et al, 1986, Sejersted, et al, 1984 ( Figure 1B). This causes blood flow restriction or occlusion to the contracting muscles on the arterial side and expels blood from the muscle on the venous side (muscle pump) (Barnes 1986, Bonde-Petersen, et al, 1975, Gaskell 1877, Kagaya and Ogita 1992, Lind and McNicol 1967, Sadamoto, et al, 1983, Sjø gaard, et al, 1986. Accordingly, changes in vessel geometry due to muscle lengthening/shortening and vessel compression due to developed muscle tension are two major factors which mechanically modify muscle circulation.…”

Section: Introductionmentioning

confidence: 99%

Muscle Architecture and its Relationship to Muscle Circulation

Kagaya

Muraoka

2005

Int. J. Sport Health Sci.

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Muscle contraction mechanically changes vessel geometry and consequently muscle circulation. Lengthening of muscle fiber straightens capillary tortuosity and further increase in muscle fiber length reduces blood flow by extending the capillary while reducing its diameter. The direction of capillary to the fiber long axis will modify the extent of capillary lumen diameter change due to lengthening muscle fiber. During passive stretching in human subjects, the relationship between changes in blood volume (determined by near-infrared spectroscopy: NIRS) and fascicle length differed among the three heads of triceps surae muscles with different fascicle length and pennation angle. Muscle thickness, muscle curvature, and muscle fascicle angle are potential determinants of intramuscular pressure during muscle contraction. Muscle circulation is impeded more in short bulging muscles with great curvature of fibers than in long slender muscles with less curvature. The different response of circulatory parameters across the synergist muscles in the calf and heterogeneity of muscle circulation in the same muscle were observed, partly due to the difference in the pennation angle of the muscle fascicle. The muscle architecture will influence venous outflow by changing the muscle pumping action. This is possibly an indirect way of modifying vasodilation due to difference in muscle architecture.

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The relationship between maximum isometric strength and intramuscular circulatory occlusion

Cited by 165 publications

References 10 publications

Effect of arterial oxygenation on quadriceps fatigability during isolated muscle exercise

Effect of arterial oxygenation on quadriceps fatigability during isolated muscle exercise

Free radical scavengers are more effective than indomethacin in the prevention of experimentally induced heterotopic ossification

Muscle Architecture and its Relationship to Muscle Circulation

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