The Relationship Between Maternal Postpartum Psychological State and Breast Milk Secretory Immunoglobulin A Level

Kawano, Atsuko; Emori, Yoko

doi:10.1177/1078390314566882

Cited by 50 publications

(48 citation statements)

References 43 publications

(50 reference statements)

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“…In addition to TGFβ2, three studies investigated the association between postpartum depression and milk sIgA levels, with one study reporting an increase of sIgA levels in depressed mothers (Hart et al, 2004), one study reporting no correlation (Groër et al, 1994) and one reporting a significant decrease of sIgA levels in depressed mothers (Kawano and Emori, 2015). Results from the last study are in line with previous evidence, showing a decrease in sIgA levels in faecal samples of children who were breastfed by depressed mothers (Kang et al, 2017).…”

Section: Immune Componentssupporting

confidence: 80%

“…Two studies did not find any significant correlation between maternal state or trait anxiety and sIgA (Groër et al, 1994), and state anxiety and sIgA milk levels (Hart et al, 2004). However, one study found a negative association between postpartum state and trait anxiety scores, and sIgA milk levels (Kawano and Emori, 2015). This is in contrast with results previously described where only state anxiety, but not trait anxiety, was associated with high ions levels in milk (Ozbek et al, 2008;Serim Demirgoren et al, 2017).…”

Section: Immune Componentsmentioning

confidence: 59%

See 1 more Smart Citation

Nutritional and immunological factors in breast milk: A role in the intergenerational transmission from maternal psychopathology to child development

Benedetto

Bottanelli

Cattaneo

et al. 2020

Brain, Behavior, and Immunity

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Perinatal psychopathologies affect more than 25% of women during and after their gestational period. These psychiatric disorders determine important biological variations in their organisms, affecting many different physiological and metabolic pathways. Of relevance, any of these changes occurring in the mother can alter the normal composition of breast milk, particularly the concentration of nutritional and inflammatory components, which play a role in child brain functioning and development. Indeed, there is evidence showing that changes in milk composition can contribute to cognitive impairments and alterations in mental abilities in children. This review aims to shed light on the unique intergenerational role played by breast milk composition, from maternal psychopathologies to child development.

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Section: Immune Componentssupporting

confidence: 80%

Section: Immune Componentsmentioning

confidence: 59%

Nutritional and immunological factors in breast milk: A role in the intergenerational transmission from maternal psychopathology to child development

Benedetto

Bottanelli

Cattaneo

et al. 2020

Brain, Behavior, and Immunity

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show abstract

“…We found no statistical interaction between the maternal distress trajectory variable and breastfeeding status in the association with fecal sIgA in study infants. However, the breastfed infant may not be impervious to maternal mood, as lower sIgA levels have been reported in the breast milk of mothers who experience anxiety . This observation may partially explain our findings in older breastfed infants.…”

Section: Discussionmentioning

confidence: 50%

Maternal psychological distress before birth influences gut immunity in mid‐infancy

Kang

Koleva

et al. 2020

Clin Experimental Allergy

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Background: Maternal pre-postnatal psychosocial distress increases the risk for childhood allergic disease. This may occur through a host immunity pathway that involves intestinal secretory immunoglobulin A (sIgA). Experimental animal models show changes in the gut microbiome and immunity of offspring when exposed to direct or prenatal maternal stress, but little is known in humans. Objective:We determined the association between maternal depression and stress symptom trajectories and infant fecal sIgA concentrations. Methods: 1043 term infants from the Canadian Healthy Infant LongitudinalDevelopment (CHILD) birth cohort were studied. Trajectories of maternal perceived stress and depression were based on scored scales administered in pregnancy and postpartum. sIgA was quantified in infant stool (mean age 3.7 months) with Immundiagnostik ELISA. Linear regression and logistic regression were employed to test associations.Results: Very low fecal sIgA concentrations were more common in infants of mothers in the antepartum and persistent depression trajectories (6% and 2% of women, respectively). Independent of breastfeeding status at fecal sampling, infant antibiotic exposure or other covariates, the antepartum depressive symptom trajectory was associated with reduced mean infant sIgA concentrations (β=−0.07, P < .01) and a two fold risk for lowest quartile concentrations (OR, 1.86; 95% CI: 1.02, 3.40). This | 179KANG et Al.

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“…SIgA serves as a defense against infections, and low salivary sIgA levels are associated with increased likelihood of illness (Jemmott & McClelland, ; Volkmann & Weekes, ). Numerous behavioral immunology studies in adults have shown that psychological distress and stressful experiences reduce breast milk (Groer, Davis, & Steele, ; Kawano & Emori, ) and salivary sIgA (Engeland et al, ; Graham, Chiron, Bartholomeusz, Taboonpong, & Brooy, ; Phillips et al, ; Segerstrom & Miller, ) while the developmental literature consistently shows maternal well‐being is a primary regulator of child development (e.g., Morris, Silk, Steinberg, Myers, & Robinson, ). Our findings extend these two fields revealing the importance of maternal well‐being for infant immunity.…”

Section: Discussionmentioning

confidence: 99%

Maternal distress across the postnatal period is associated with infant secretory immunoglobulin A

Ellberg

Sayler

Hibel

2019

Developmental Psychobiology

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Employing a longitudinal design, relationships between maternal distress (i.e., perceived stress, negative affect, depressive symptomology), and infant secretory immunoglobulin A (sIgA) across the peripartum period were examined in 51 mother-infant dyads. Indices of maternal distress were assessed at four time periods: third trimester of pregnancy and 1, 3, and 6 months postpartum. Infant saliva samples were collected at each of the three time points in the postpartum period to assess sIgA levels. No relationships were found between prenatal maternal distress and infant sIgA. Results indicated that during the postnatal period, higher concurrent maternal distress was associated with reduced infant sIgA. Maternal distress did not prospectively predict infant sIgA. These findings advance our understanding of the social-context of infant development, highlighting the significance of maternal regulation of infant immunity. K E Y W O R D Sinfant immunity, maternal depression, maternal mood, maternal stress, salivary secretory immunoglobulin A

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The Relationship Between Maternal Postpartum Psychological State and Breast Milk Secretory Immunoglobulin A Level

Abstract: These results indicate that the maternal psychological state may affect the immune properties of breast milk.

Cited by 50 publications

References 43 publications

Nutritional and immunological factors in breast milk: A role in the intergenerational transmission from maternal psychopathology to child development

Nutritional and immunological factors in breast milk: A role in the intergenerational transmission from maternal psychopathology to child development

Maternal psychological distress before birth influences gut immunity in mid‐infancy

Maternal distress across the postnatal period is associated with infant secretory immunoglobulin A

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