The Relationship between MALAT1 Polymorphism rs3200401 C &gt; T and the Risk of Overall Cancer: A Meta-Analysis

Li, Keming; Han, Ze‐Guang; Wu, Jinyu; Ye, Hua; Sun, Guiying; Shi, Jianxiang; Zhang, Jianying; Wang, Peng

doi:10.3390/medicina58020176

Cited by 5 publications

(3 citation statements)

References 42 publications

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“…Wang et al showed that T allele of rs3200401 was protective factor in survival outcomes of patients with advanced lung adenoma 9 . In a recent meta-analysis that did not include lung cancer, the researchers did not find a relationship between the MALAT1 rs3200401 polymorphism and overall cancer risk, rs3200401 C > T polymorphism plays different roles in cancers 52 . Our study revealed that rs3200401 reduces the risk of non-small cell lung cancer and lung squamous cell carcinoma.…”

Section: Discussionmentioning

confidence: 97%

MALAT1 Polymorphisms and Lung Cancer Susceptibility in a Chinese Northeast Han Population

Tong¹,

Tong²,

He³

et al. 2022

Int. J. Med. Sci.

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Background: LncRNA MALAT1 (metastasis-associated lung adenocarcinoma transcript 1) was competitive endogenous RNA (ceRNA) involved in various molecular processes for metastasis development in lung cancer. Single nucleotide polymorphisms (SNPs) in MALAT1 gene might be predictive markers for lung cancer. In our study, we selected rs619586 and rs3200401 in MALAT1 gene to explore their effects on lung cancer susceptibility. Methods: The case-control study included 444 lung cancer cases and 460 healthy controls. Genotyping was performed by Taqman allelic discrimination method. Logistic regression, Student t-test, and Chi-square test (χ 2 ) were used to analyze the data. Results:The findings of the study showed that rs3200401 was significantly associated with the risk of non-small cell lung cancer (NSCLC) and lung squamous cell carcinoma (LUSC). Compared with homozygous CC genotype, CT heterozygous genotype decreased risk of NSCLC (P a = 0.034) and LUSC (P a = 0.025). In addition, no statistical association was detected between rs619586 and lung cancer susceptibility. The interactions between genes and cigarette smoking were discovered via crossover analysis. However, there were no remarkable gene-environment interactions in additive and multiplicative model. Conclusion: Rs3200401 in lncRNA MALAT1 was associated with the susceptibility of non-small-cell lung cancer and lung squamous cell carcinoma. The gene-environmental (cigarette smoking) interactions were not notable.

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Section: Discussionmentioning

confidence: 97%

MALAT1 Polymorphisms and Lung Cancer Susceptibility in a Chinese Northeast Han Population

Tong¹,

Tong²,

He³

et al. 2022

Int. J. Med. Sci.

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“…Additionally, a recent metaanalysis conducted by Li et al found no significant association between the MALAT1 rs3200401C/T variant and the overall cancer risk. However, it may be linked to a higher risk of colorectal cancer, which needs more studies for further validation [73]. Other MALAT1 functional variants have shown associations with the risk of cancer, for example, colorectal cancer (rs619586, rs664589, and rs1194338) and hepatocellular cancer (rs619586), as confirmed by the recent meta-analysis conducted by Cao et al [74].…”

Section: Discussionmentioning

confidence: 81%

Angio-Long Noncoding RNA MALAT1 (rs3200401) and MIAT (rs1061540) Gene Variants in Ovarian Cancer

Fawzy,

Ibrahiem,

Osman

et al. 2024

Epigenomes

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The genotyping of long non-coding RNA (lncRNA)-related single-nucleotide polymorphisms (SNPs) could be associated with cancer risk and/or progression. This study aimed to analyze the angiogenesis-related lncRNAs MALAT1 (rs3200401) and MIAT (rs1061540) variants in patients with ovarian cancer (OC) using “Real-Time allelic discrimination polymerase chain reaction” in 182 formalin-fixed paraffin-embedded (FFPE) samples of benign, borderline, and primary malignant ovarian tissues. Differences in the genotype frequencies between low-grade ovarian epithelial tumors (benign/borderline) and malignant tumors and between high-grade malignant epithelial tumors and malignant epithelial tumors other than high-grade serous carcinomas were compared. Odds ratios (ORs)/95% confidence intervals were calculated as measures of the association strength. Additionally, associations of the genotypes with the available pathological data were analyzed. The heterozygosity of MALAT1 rs3200401 was the most common genotype (47.8%), followed by C/C (36.3%). Comparing the study groups, no significant differences were observed regarding this variant. In contrast, the malignant epithelial tumors had a higher frequency of the MIAT rs1061540 C/C genotype compared to the low-grade epithelial tumor cohorts (56.7% vs. 37.6, p = 0.031). The same genotype was significantly higher in high-grade serous carcinoma than its counterparts (69.4% vs. 43.8%, p = 0.038). Multivariate Cox regression analysis showed that the age at diagnosis was significantly associated with the risk of OC development. In contrast, the MIAT T/T genotype was associated with a low risk of malignant epithelial tumors under the homozygote comparison model (OR = 0.37 (0.16–0.83), p = 0.017). Also, MIAT T allele carriers were less likely to develop high-grade serous carcinoma under heterozygote (CT vs. CC; OR = 0.33 (0.12–0.88), p = 0.027) and homozygote (TT vs. CC; OR = 0.26 (0.07–0.90), p = 0.034) comparison models. In conclusion, our data provide novel evidence for a potential association between the lncRNA MIAT rs1061540 and the malignant condition of ovarian cancer, suggesting the involvement of such lncRNAs in OC development.

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“…Genetic polymorphisms in lncRNAs may influence their expression and function, and thus increase or decrease an individual's susceptibility to the disease, to the extent that the lncRNAs are the direct causative contributors rather than mere genetic markers; this feature would help to assess disease risk and clinical prognosis [21,22]. The SNPs rs3200401 in MALAT1 and rs217727 in H19 are associated with increased risk of T2D [23,24] and different types of cancers [25,26]. Several studies have suggested that there is association between the SNPs rs3200401 and rs217727, and the etiological mechanisms of obesity, such as insulin dysregulation, and abnormal lipid and glucose metabolism [13,20,24].…”

Section: Introductionmentioning

confidence: 99%

The Role of Genetic Variants in the Long Non-Coding RNA Genes MALAT1 and H19 in the Pathogenesis of Childhood Obesity

Шкурат

Ammar

Bocharova

et al. 2023

ncRNA

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Long non-coding RNAs (lncRNAs) play important roles in the maintenance of metabolic homeostasis. Recently, many studies have suggested that lncRNAs, such as Metastasis Associated Lung Adenocarcinoma Transcript 1 (MALAT1) and Imprinted Maternally Expressed Transcript (H19), might participate in the pathogenesis of metabolic disorders such as obesity. We conducted a case-control study with 150 Russian children and adolescents aged between 5 and 17 years old in order to assess the statistical association between the single nucleotide polymorphisms (SNPs) rs3200401 in MALAT1 and rs217727 in H19, and the risk of developing obesity in this population. We further explored the possible association of rs3200401 and rs217727 with BMI Z-score and insulin resistance. The MALAT1 rs3200401 and H19 rs217727 SNPs were genotyped using Taqman SNP genotyping assay. The MALAT1 rs3200401 SNP was identified as a risk factor for childhood obesity (p < 0.05) under the dominant and allelic models, and the CT heterozygous genotype was associated with the risk of increased BMI and with insulin resistance. The H19 rs217727 SNP had no significant association with obesity risk (all p > 0.05). Our findings thus suggest that MALAT1 SNP rs3200401 is a potential indicator of obesity susceptibility and pathogenesis in children and adolescents.

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The Relationship between MALAT1 Polymorphism rs3200401 C > T and the Risk of Overall Cancer: A Meta-Analysis

Cited by 5 publications

References 42 publications

MALAT1 Polymorphisms and Lung Cancer Susceptibility in a Chinese Northeast Han Population

MALAT1 Polymorphisms and Lung Cancer Susceptibility in a Chinese Northeast Han Population

Angio-Long Noncoding RNA MALAT1 (rs3200401) and MIAT (rs1061540) Gene Variants in Ovarian Cancer

The Role of Genetic Variants in the Long Non-Coding RNA Genes MALAT1 and H19 in the Pathogenesis of Childhood Obesity

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