The Relationship Between Major Food Sources of Fructose and Cardiovascular Outcomes: A Systematic Review and Dose-Response Meta-Analysis of Prospective Studies

Sun, Tao; Zhang, Yabing; Ding, Lin; Zhang, Yonggang; Li, Tao; Li, Qian

doi:10.1016/j.advnut.2022.12.002

Cited by 9 publications

(4 citation statements)

References 110 publications

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“…Recent meta-analyses of prospective studies have reported no associations (11)(12)(13) or indications of inverse associations (11) between the intake of fruit juice and the risk of cardiovascular disease incidence and/or mortality, comparing high versus low intake. A beneficial effect was noted particularly for stroke.…”

Section: Health Outcomes Relevant For Nordic and Baltic Countriesmentioning

confidence: 99%

Fruit juice – a scoping review for Nordic Nutrition Recommendations 2023

Rosell,

Nyström

2024

Food & Nutrition Research

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Fruit juice has a similar nutrient content as whole fruit and may in this respect be part of a healthy diet. However, a lower amount or lack of fibre and a higher concentration of sugars and energy could also contribute to less satiation and increase the risk of excess energy intake. The aim of this scoping review is to describe the overall evidence for the role of fruit juice as a basis for setting and updating food-based dietary guidelines in the Nordic Nutrition Recommendations 2023. PubMed was searched for systematic reviews and meta-analyses and evidence was extracted on relevant health outcomes. Current available evidence indicates that low to moderate consumption of fruit juice is not associated with an apparent risk of chronic diseases and may have protective effects on cardiovascular disease. The association between the intake of fruit juice and weight gain remains unclear and might be of concern for some groups of people. Overall, the evidence regarding health effects of fruit juice is limited.

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Section: Health Outcomes Relevant For Nordic and Baltic Countriesmentioning

confidence: 99%

Fruit juice – a scoping review for Nordic Nutrition Recommendations 2023

Rosell,

Nyström

2024

Food & Nutrition Research

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“…Regarding evidence for other outcomes than cancer, recent meta-analyses have shown inverse associations between total fruit and vegetable intake combined as well as separately and cardiovascular disease incidence and mortality, including coronary heart disease and stroke (17)(18)(19)(20). The risk reductions for high versus low intakes are generally in the range of 10-20%.…”

Section: Health Outcomes Relevant For Nordic and Baltic Countriesmentioning

confidence: 99%

Vegetables, fruits, and berries – a scoping review for Nordic Nutrition Recommendations 2023

Rosell,

Fadnes

2024

Food & Nutrition Research

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Vegetables, fruits, and berries comprise a large variety of foods and are recognised to play an important role in preventing chronic diseases. Many observational studies have been published during the last decade, and the aim of this scoping review is to describe the overall evidence for the role of vegetables, fruits, and berries for health-related outcomes as a basis for setting and updating food-based dietary guidelines. A scoping review was conducted according to the protocol developed within the Nordic Nutrition Recommendations 2023 project. Current available evidence strengthens the role of consuming vegetables, fruits, and berries in preventing chronic diseases. The most robust evidence is found for cancer in the gastric system and lung cancer, cardiovascular disease, and all-cause mortality. Steeper risk reductions are generally seen at the lower intake ranges, but further reductions have been seen for higher intakes for cardiovascular disease. Weaker associations are seen for type 2 diabetes. There is evidence that suggests a beneficial role also for outcomes such as osteoporosis, depression, cognitive disorders, and frailty in the elderly. The observed associations are supported by several mechanisms, indicting causal effects. Some subgroups of vegetables, fruits, and berries may have greater benefits than other subgroups, supporting a recommendation to consume a variety of these foods.

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“…For example, the odds of drinking SSBs one or more times per day is significantly higher among non-Hispanic black respondents (AOR = 1.65) versus non-Hispanic white respondents 8 . This shift in increased SSB consumption and documented racial disparities are gravely concerning given the increasingly recognized role of excess dietary fructose in various, negative health outcomes [11][12][13] , including two recent landmark murine studies, which have begun to define mechanisms linking SSB/HFCS to colon carcinogenesis 14,15 . Despite these studies, the role of dietary fructose in healthy human colon, and as such, the mechanisms that may drive fructose-mediated CRC risk, remain poorly understood.…”

Section: Introductionmentioning

confidence: 99%

Potential role of fructose on human colon DNA methylation in racial disparities observed for colorectal cancer risk

Devall,

Eaton,

et al. 2023

Preprint

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Background and aims: An increasing body of observational studies has linked fructose intake to colorectal cancer (CRC). African Americans (AAs) are significantly more likely than European Americans to consume greater quantities of fructose and to develop right-side colon cancer. Yet, a mechanistic link between these two associations remains poorly defined. We aimed to identify differentially methylated regions (DMRs) associated with dietary fructose consumption measures obtained from food frequency questionnaires in a cohort of normal colon biopsies derived from AA men and women (n=79). Methods: DNA methylation data from this study was obtained using the Illumina Infinium MethylationEPIC kit and is housed under accession GSE151732. DMR analysis was carried out using DMRcate in right and matched left colon, separately. Secondary analysis of CRC tumors was carried out using data derived from TCGA-COAD, GSE101764 and GSE193535. Differential expression analysis was carried out on CRC tumors from TCGA-COAD using DESeq2. Results: We identified 4,263 right-side fructose-DMRs. In contrast, only 24 DMRs survived multiple testing corrections (FDR<0.05) in matched, left colon. To identify targets by which dietary fructose drives CRC risk, we overlaid these findings with data from three CRC tumor datasets. Remarkably, almost 50% of right-side fructose-DMRs overlapped regions associated with CRC in at least one of three datasets. TNXB and CDX2 ranked among the most significant fructose risk DMRs in right and left colon respectively that also displayed altered gene expression in CRC tumors. Conclusions: Our mechanistic data support the notion that fructose has a greater CRC-related effect in right than left AA colon, alluding to a potential role for fructose in contributing to racial disparities in CRC.

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The Relationship Between Major Food Sources of Fructose and Cardiovascular Outcomes: A Systematic Review and Dose-Response Meta-Analysis of Prospective Studies

Cited by 9 publications

References 110 publications

Fruit juice – a scoping review for Nordic Nutrition Recommendations 2023

Fruit juice – a scoping review for Nordic Nutrition Recommendations 2023

Vegetables, fruits, and berries – a scoping review for Nordic Nutrition Recommendations 2023

Potential role of fructose on human colon DNA methylation in racial disparities observed for colorectal cancer risk

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