The relationship between magnesium and osteoarthritis of knee

Wu, Zhengtao; Yang, Juguang; Liu, Jiangtao; Lian, Kai

doi:10.1097/md.0000000000017774

Cited by 10 publications

(5 citation statements)

References 29 publications

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“…Magnesium supplementation in elderly patients may reduce the risk of knee osteoarthritis. Magnesium supplementation may also improve the symptoms and progression of knee osteoarthritis ( Wu et al., 2019 ). Although there has been no traditional epidemiological study of the relationship between magnesium and gout, a MR study suggested a positive link with the risk of gout ( Cheng et al., 2019 ).…”

Section: Discussionmentioning

confidence: 99%

MR-PheWAS for the causal effects of serum magnesium on multiple disease outcomes in Caucasian descent

Yang

Huang

et al. 2021

iScience

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Magnesium is integral to many physiological processes, whereas variations in its levels, even within the normal range, can have critical implications for health. To explore the broad clinical effects of varying serum magnesium levels, we performed a two-sample Mendelian randomization and phenome-wide association study (MR-PheWAS) in the UK Biobank cohort. In total, MR-PheWAS analysis implicated a causal role of serum magnesium levels in five disease groups and six disease outcomes. In addition, our study indicated the gender-specific effects of nine disease groups/outcomes in MR estimated effects. The protein-protein interaction network demonstrated an interaction between the serum magnesium-associated gene DCDC1 and the cataract-associated gene PAX6. The present study verified several previously reported disease outcomes and identified novel potential disease outcomes for serum magnesium levels. The DCDC1 gene and the PAX6 gene may be the new targets for promoting the treatments of cataracts using magnesium intervention.

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Section: Discussionmentioning

confidence: 99%

MR-PheWAS for the causal effects of serum magnesium on multiple disease outcomes in Caucasian descent

Yang

Huang

et al. 2021

iScience

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“…Wu Z, et al In their study (22). In this particular research, a higher magnesium consumption was not connected with a decreased incidence of knee osteoarthritis.…”

Section: Resultsmentioning

confidence: 58%

Study the Level of Collagen2-1NO2 (Coll2-1NO2) in Serum of Iraqi Patients with Osteoarthritis

Mutar¹,

Hasan²,

Muhi³

2022

PJMHS

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Osteoarthritis, often known as OA, is characterized by the degeneration of articular cartilage, limited intraarticular inflammation with synovitis, and peri-articular and subchondral bone changes. This study measured Coll2-1NO2, CRP, ESR, Vitamin D3, Mg, Calcium, and Lipid profiles in OA patients. The current study contained a total of 130 participants, who were divided into two groups. Group1 contained 90 OA patients, and group 2 controls 40; the samples were extracted from females and males, the levels, Coll2-1 NO2, CRP, ESR , Vitamin D3 ,Mg, Calcium, Cholesterol, TG, VLDL, LDL, and HDL were calculated. The levels of Coll2-1NO2, CRP, and Vitamin D3 were evaluated using an enzyme-linked immunosorbent assay (ELISA), while the levels of Mg, Calcium, Cholesterol, TG, VLDL, LDL, and HDL were determined using a Human Reader HS Device. Westergren method was used to analyze the level of ESR . The result of Coll2-1NO2 shows a high significant change among OA patients and control. Serum vitamin D3 and CRP value have high significant change in their levels in OA patients. Serum levels of Triglyceride, HDL, Mg, Ca, ESR and VLDL showed a significant variation among OA patient and control. Cholesterol and LDL values have non-significant variation in their levels in OA patients in comparison with control. Conclusion: According to the presented results Coll2-1NO2, CRP, ESR, Vitamin D3, Mg, Calcium, T.G, VLDL, and HDL do affect by Osteoarthritis patients. LDL and cholesterol don’t affect osteoarthritis patients.

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“…Although some studies on human subjects have indicated an important role of Mg +2 intake in preventing the onset and progression of KOA, they have been contradicted by studies that did not obtain a lower risk of KOA in increased Mg +2 intake, or that noticed only modest inverse associations between them (34). On the other hand, Wu and his colleagues, claim a lower risk of KOA in association with higher serum Mg +2 values, but more evaluations are needed to confirm this hypothesis (35).…”

Section: Discussionmentioning

confidence: 99%

Role of Progranulin and its Implication in Knee Osteoarthritis among Iraqi Patients

Al-Ghafoor¹,

Ahmed²

2022

PJMHS

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Background: Osteoarthritis is a complicated, chronic disorder of cartilage and bone, associated with homeostasis of bio-elements. The current study aims to assess the role of serum progranulin levels among Iraqi patients with knee osteoarthritis. Patients and Methods: The study encompassed 50 patients aged 52.50 ± 3.12 years (25 males and 25 females), admitted to the at the Baghdad Medical City through the period from November 2021 to March 2022. All individuals were identified by physicians in a Rheumatology and Rehabilitation Outpatient Clinic and the clinical data was collected along with the assess¬ment of biochemical parameters. Fasting serum glucose, lipid profile, calcium, magnesium, alkaline phosphatase, vitamin D3, and progranulin levels were determined. Results: All patients in this study had higher levels of serum glucose and dyslipidemia with significant increases (p < 0.05) in alkaline phosphatase and progranulin levels and considerable reduced (p < 0.05) in serum calcium, magnesium, and vitamin D3 as compared to healthy group. Additionally, hypovitaminosis D were appeared in all patients and progranulin levels were (56.30±8.50 ng/mL) vs. (40.45 ± 8.90 ng/mL) in control group with OR and CI= 1.54 (0.97-2.58). Conclusions: Inflammation has an integral role in the pathogenesis of osteoarthritis. Serum vitamin D3 level is considerably low in patients with knee osteoarthritis paralleled to healthy individuals. However, this study demonstrates increased progranulin levels in knee osteoarthritis patients and associates with vitamin D level, disease activity, and inflammation among those patients. Keywords: Knee osteoarthritis, Calcium, Magnesium, Alkaline phosphatase,Vitamin D3, Progranulin.

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The relationship between magnesium and osteoarthritis of knee

Cited by 10 publications

References 29 publications

MR-PheWAS for the causal effects of serum magnesium on multiple disease outcomes in Caucasian descent

MR-PheWAS for the causal effects of serum magnesium on multiple disease outcomes in Caucasian descent

Study the Level of Collagen2-1NO2 (Coll2-1NO2) in Serum of Iraqi Patients with Osteoarthritis

Role of Progranulin and its Implication in Knee Osteoarthritis among Iraqi Patients

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