The Relationship Between Low Serum Vitamin D Level and Early Dental Implant Failure: A Systematic Review

Alsulaimani, Lujain; Alqarni, Abdullah; Almarghlani, Ammar; Hassoubah, Mawadah

doi:10.7759/cureus.21264

Cited by 9 publications

(7 citation statements)

References 47 publications

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“…A high rate of vitamin D deficiency (VDD) is reported among AD individuals; for instance, a study from 2022 on five European cohorts, a total of 1028 patients with autoimmune AD, found that 34–57% of them had VDV, defined as a level of 25-hydroxyvitamin D (25OHD) between 10 and 20 ng/mL, while 5–22% had severe VDV (a value of 25OHD below 10 ng/mL) [ 140 ]. VDV impacts general oral health, especially in children, pregnant women, and seniors (where reports showed correlations with bone density); it is suggested to be an additional contributor to PD, and probably to dental implant failure [ 141 , 142 , 143 ]. VD replacement might help the process of osseous integration after dental implants, as its role in bone healing has been noted [ 144 , 145 ].…”

Section: Methodsmentioning

confidence: 99%

New Approach to Addison Disease: Oral Manifestations Due to Endocrine Dysfunction and Comorbidity Burden

et al. 2022

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This review highlights oral anomalies with major clinical impact in Addison disease (AD), including dental health and dermatologic features, through a dual perspective: pigmentation issues and AD comorbidities with oral manifestations. Affecting 92% of AD patients, cutaneomucosal hyperpigmentation is synchronous with or precedes general manifestations by up to a decade, underlying melanocytic infiltration of the basal epidermal layer; melanophages in the superficial dermis; and, rarely, acanthosis, perivascular lymphocytic infiltrate, and hyperkeratosis. Intraoral pigmentation might be the only sign of AD; thus, early recognition is mandatory, and biopsy is helpful in selected cases. The buccal area is the most affected location; other sites are palatine arches, lips, gums, and tongue. Pigmented oral lesions are patchy or diffuse; mostly asymptomatic; and occasionally accompanied by pain, itchiness, and burn-like lesions. Pigmented lingual patches are isolated or multiple, located on dorsal and lateral areas; fungiform pigmented papillae are also reported in AD individuals. Dermoscopy examination is particularly indicated for fungal etiology; yet, it is not routinely performed. AD’s comorbidity burden includes the cluster of autoimmune polyglandular syndrome (APS) type 1 underlying AIRE gene malfunction. Chronic cutaneomucosal candidiasis (CMC), including oral CMC, represents the first sign of APS1 in 70–80% of cases, displaying autoantibodies against interleukin (IL)-17A, IL-17F ± IL-22, and probably a high mucosal concentration of interferon (IFN)-γ. CMC is prone to systemic candidiasis, representing a procarcinogenic status due to Th17 cell anomalies. In APS1, the first cause of mortality is infections (24%), followed by oral and esophageal cancers (15%). Autoimmune hypoparathyroidism (HyP) is the earliest endocrine element in APS1; a combination of CMC by the age of 5 years and dental enamel hypoplasia (the most frequent dental complication of pediatric HyP) by the age of 15 is an indication for HyP assessment. Children with HyP might experience short dental roots, enamel opacities, hypodontia, and eruption dysfunctions. Copresence of APS-related type 1 diabetes mellitus (DM) enhances the risk of CMC, as well as periodontal disease (PD). Anemia-related mucosal pallor is related to DM, hypothyroidism, hypogonadism, corresponding gastroenterological diseases (Crohn’s disease also presents oral ulceration (OU), mucogingivitis, and a 2-3 times higher risk of PD; Biermer anemia might cause hyperpigmentation by itself), and rheumatologic diseases (lupus induces OU, honeycomb plaques, keratotic plaques, angular cheilitis, buccal petechial lesions, and PD). In more than half of the patients, associated vitiligo involves depigmentation of oral mucosa at different levels (palatal, gingival, alveolar, buccal mucosa, and lips). Celiac disease may manifest xerostomia, dry lips, OU, sialadenitis, recurrent aphthous stomatitis and dental enamel defects in children, a higher prevalence of caries and dentin sensitivity, and gingival bleeding. Oral pigmented lesions might provide a useful index of suspicion for AD in apparently healthy individuals, and thus an adrenocorticotropic hormone (ACTH) stimulation is useful. The spectrum of autoimmune AD comorbidities massively complicates the overall picture of oral manifestations.

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Section: Methodsmentioning

confidence: 99%

New Approach to Addison Disease: Oral Manifestations Due to Endocrine Dysfunction and Comorbidity Burden

et al. 2022

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“…Durante la oseointegración el calcitriol afecta la activación y diferenciación de osteoblastos y osteoclastos, entonces la vitamina aumenta la mineralización ósea, también se ha descubierto que participa en la maduración y función las células óseas por su actividad precursora. 15 Por otra parte, una regeneración ósea es un procedimiento que comúnmente se puede llevar antes o durante la colocación de un implante y resultados de estudios in vitro indican que tiene un alto potencial terapéutico debido a que existe una mejoría en la diferenciación de células madre en los osteoblastos. 16 La dosis recomendada según el Instituto de Medicina de los EE.…”

Section: Factores Relacionados a La Deficiencia De Vitamina D Y La Os...unclassified

Niveles bajos de vitamina D y su efecto en la oseointegración: revisión sistemática.

Xicoténcatl¹,

Flores²

2023

Revista De La Asociación Dental Mexicana

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Introduction: vitamin D is a hormone that is synthesized by skin cells using UV light and consumed through the diet. The relationship established between vitamin D deficiency and the failure of bone grafts or implants is based on immunological and inflammatory alterations due to the intimate link with innate and adaptive immunity. Objective: to identify the factors that occur in the periodontium when there are low levels of vitamin D and periodontal treatments such as bone grafts and implants are performed. Material and methods: a search for articles was carried out in PubMed and Google Scholar (Spanish and English). Results: vitamin D affects and predisposes to graft rejection, absence of osseointegration in implants due to immunomodulation. Conclusion: the success of the treatment becomes predictable when optimal levels of vitamin D are found together with the correct surgical approach techniques that allow the generation of an ideal integration of the periodontal tissues.

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“…Moreover, a recent systematic review concluded that it is difficult to prove a direct relationship or causality between low serum vitamin D levels and early dental implant failures. The small number of clinical trials and their limited number of patients make it necessary to carry out future research to clarify the specific role of vitamin D deficiencies 402 . Conclusions from other systematic reviews were the opposite: serum vitamin D levels in patients may play a relevant role in osseointegration, marginal bone loss, and dental implant survival 403 …”

Section: Diet‐related Factors Altering Bone Metabolismmentioning

confidence: 99%

Emerging factors affecting peri‐implant bone metabolism

Insua,

Galindo‐Moreno,

Miron

et al. 2023

Periodontology 2000

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Implant dentistry has evolved to the point that standard implant osseointegration is predictable. This is attributed in part to the advancements in material sciences that have led toward improvements in implant surface technology and characteristics. Nonetheless, there remain several cases where implant therapy fails (specifically at early time points), most commonly attributed to factors affecting bone metabolism. Among these patients, smokers are known to have impaired bone metabolism and thus be subject to higher risks of early implant failure and/or late complications related to the stability of the peri‐implant bone and mucosal tissues. Notably, however, emerging data have unveiled other critical factors affecting osseointegration, namely, those related to the metabolism of bone tissues. The aim of this review is to shed light on the effects of implant‐related factors, like implant surface or titanium particle release; surgical‐related factors, like osseodensification or implanted biomaterials; various drugs, like selective serotonin reuptake inhibitors, proton pump inhibitors, anti‐hypertensives, nonsteroidal anti‐inflammatory medication, and statins, and host‐related factors, like smoking, diet, and metabolic syndrome on bone metabolism, and aseptic peri‐implant bone loss. Despite the infectious nature of peri‐implant biological complications, these factors must be surveyed for the effective prevention and management of peri‐implantitis.

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The Relationship Between Low Serum Vitamin D Level and Early Dental Implant Failure: A Systematic Review

Cited by 9 publications

References 47 publications

New Approach to Addison Disease: Oral Manifestations Due to Endocrine Dysfunction and Comorbidity Burden

New Approach to Addison Disease: Oral Manifestations Due to Endocrine Dysfunction and Comorbidity Burden

Niveles bajos de vitamina D y su efecto en la oseointegración: revisión sistemática.

Emerging factors affecting peri‐implant bone metabolism

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