The Relationship Between Lipoproteins and Insulin Sensitivity in Youth With Obesity and Abnormal Glucose Tolerance

Chung, Stephanie T.; Katz, Lorraine E. Levitt; Stettler-Davis, Nicolas; Shults, Justine; Sherman, Arthur; Ha, Joon; Stefanovski, Darko; Boston, Ray; Rader, Daniel J.; Magge, Sheela N.

doi:10.1210/clinem/dgac113

Cited by 12 publications

(7 citation statements)

References 48 publications

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“…The effects of vitamin D on glucose homeostasis, exerted mainly by its active form 1,25-dihydroxycholecalciferol, include the increase of peripheral and hepatic glucose uptake, the improvement in synthesis and secretion of insulin, the protection of b-cells from cytokine induced apoptosis and attenuation of inflammation (47, 54-56). It has been confirmed that insulin resistance affects obesity-related pro-atherogenic changes in lipid profile (57,58). Insulin resistance impairs the function of insulindependent hormone-sensitive lipase and lipoprotein lipase, which are involved in lipid metabolism, whereas insulin cannot act effectively due to obesity and dyslipidaemia (59,60).…”

Section: Discussionmentioning

confidence: 97%

The link between vitamin D, chemerin and metabolic profile in overweight and obese children - preliminary results

et al. 2023

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BackgroundVitamin D affects adipogenesis, oxidative stress, inflammation, secretion of adipocytokines, lipid metabolism and thermogenesis. Some researchers postulate that those effects could be exerted by the influence of vitamin D on chemerin levels.Aim of the studyWe aimed to investigate if there is a link between serum 25-hydroksyvitamin D [25(OH)D], chemerin and metabolic profile in overweight and obese children before and after vitamin D supplementation.Material and methodsThe prospective study included 65 overweight and obese children aged 9.08-17.5 years and 26 peers as a control. None of the patients in the study group had received vitamin D within the last twelve months before the study.ResultsThe study group had lower baseline 25(OH)D (p<0.001) and higher chemerin (p<0.001), triglycerides (TG, p<0.001), triglycerides/high density lipoprotein cholesterol (TG/HDL-C, p<0.001), C-reactive protein (CRP, p<0.05), fasting insulin (p<0.001), Homeostasis Model Assessment - Insulin Resistance (HOMA-IR, p<0.001), alanine aminotransferase (ALT, p<0.001) and uric acid (p<0.001) compared to the control group. Baseline vitamin D was related to fasting insulin (R=-0.29, p=0.021), HOMA-IR (R=-0.30, p=0.016), HDL-C (R=0.29, p=0.020) and uric acid (R=-0.28, p=0.037) in the study group. Baseline chemerin was related to insulin at 30’ (R=0.27, p=0.030), 60’ (R=0.27, p=0.033), 90’ (R=0.26, p=0.037) and 120’ (R=0.26, p=0.040) during the oral glucose tolerance test (OGTT) and ALT (R=0.25, p=0.041) in the study group. Correlation between vitamin D and chemerin (R=-0.39, p=0.046) was found only in the control group. After six months of vitamin D supplementation a decrease in CRP (p<0.01), total cholesterol (p<0.05), ALT (p<0.01), glucose at 150’ OGTT (p<0.05) was observed. Moreover, we noticed a tendency for negative association between 25(OH)D and chemerin levels (p=0.085). Multivariable backward linear regression models were build using baseline vitamin D, baseline chemerin and six months chemerin as the dependent variables.ConclusionsOur study confirmed that vitamin D has positive effect on metabolic profile in overweight and obese children. The relationship between vitamin D and chemerin is not clear, nevertheless we have observed a tendency to decrease chemerin concentrations after improving vitamin D status, even without a significant reduction in body fat mass.

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Section: Discussionmentioning

confidence: 97%

The link between vitamin D, chemerin and metabolic profile in overweight and obese children - preliminary results

et al. 2023

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“…This is consistent with the established function of apoA-I in facilitating reverse cholesterol transport and its anti-inflammatory properties, which could potentially mitigate GDM risk through enhanced lipid metabolism as well as reduced inflammation [ 27 , 28 ]. Similarly, the inverse association between HDL cholesterol and the risk of GDM is indicative of the protective role of high-density lipoproteins in cardiovascular health, potentially exerting a similar influence on GDM by modulating lipid homeostasis and insulin sensitivity [ 29 , 30 ]. On the other hand, dysregulated triglyceride levels may increase vulnerability to GDM, as suggested by the positive connection found between triglycerides and GDM risk.…”

Section: Discussionmentioning

confidence: 99%

Lipids, apolipoproteins and gestational diabetes mellitus: a Mendelian randomization study

Shan,

Wang,

2024

BMC Pregnancy Childbirth

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Background This study investigates the causal relationship between lipid traits and GDM in an effort to better understand the aetiology of GDM. Methods Employing a two-sample Mendelian Randomization (MR) framework, we used Single Nucleotide Polymorphisms (SNPs) as instrumental variables to examine the impact of lipids and apolipoproteins on GDM. The research comprised univariable and multivariable MR analyses, with a prime focus on individual and combined effects of lipid-related traits. Statistical techniques included the fixed-effect inverse variance weighted (IVW) method and supplementary methods such as MR-Egger for comprehensive assessment. Results Our findings revealed the following significant associations: apoA-I and HDL cholesterol were inversely correlated with GDM risk, while triglycerides showed a positive correlation. In multivariable analysis, apoA-I consistently exhibited a strong causal link with GDM, even after adjusting for other lipids and Body Mass Index (BMI). Conclusion The study demonstrates a significant causal relationship between apoA-I and GDM risk.

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“…In this study, a significant correlation was observed between fasting blood glucose levels and ESA in the case group ( P = .001). Another study conducted by Zolghadri et al, [ 11 ] which examined the incidence of abnormal glucose tolerance in patients with spontaneous abortion, found that patients with a history of repeated abortion had a higher rate of impaired glucose tolerance than the normal group. In our study, the mean fasting blood glucose levels in the ESA population were significantly higher than those in the control population, supporting the findings of the studies mentioned earlier.…”

Section: Discussionmentioning

confidence: 99%

A study examining the correlation between serum 25-OH-VitD levels, CD3-CD19+ B lymphocytes, and the risk of early spontaneous abortion in pregnant women

2023

Medicine

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The objective of this retrospective cohort study was to investigate the correlation between serum 25-OH-VitD levels, coagulation function, immune factors, and the risk of spontaneous abortion in the first trimester of pregnancy. Additionally, independent risk factors for spontaneous abortion in the first trimester of pregnancy were identified. A total of 412 pregnant women who attended Hubei Maternal and Child Health Care Hospital between October 2021 and February 2022 were included in the study. Of these, 221 met the eligibility criteria and were categorized into the early spontaneous abortion case group (n = 107) or the normal pregnancy control group (n = 114). The serum levels of 25-OH-VitD, CD3 + CD19- T lymphocytes, CD3-CD19 + B lymphocytes, NK (Natural Killer) cells, TNF-α (tumor necrosis factor-α) and coagulation factors (D-dimer, Protein C, Protein S) in both these groups were measured during early pregnancy (within 12 weeks) and evaluated using logistic regression analysis. Compared to the control group, body mass index, Protein S, CD19 + CD3-B lymphocytes, and 25-OH-VitD were significantly lower in the spontaneous abortion group during early pregnancy (P = .001; P = .004; P = .009; P = .001), blood glucose (fasting) and TNF-α significantly increased (P = .001; P = .046). Logistic regression analysis of potential mixed factors showed that fasting blood glucose and TNF-α were significantly different from the control group and were positively correlated (P = .001, P = .038). Fasting blood glucose 0R value is 2.264, 95% confidence interval is 0.043~0.25, TNF-α 0R value is 0.126, 95% confidence interval is 0.800~0.972. CD19 + CD3-B cells and 25-OH-VitD were correlated with spontaneous abortion (P = .005; P = .001), respectively 0R value and 95% confidence interval being −0.007 (1.002~1.012), −0.179 (1.139~1.256). Risk factors for spontaneous abortion in the first trimester (<12 weeks) of pregnancy include fasting glucose tolerance, decreased CD19 + CD3-energy B lymphocytes and 25-OH-VitD, and abnormal increase of TNF-α. Therefore, it is recommended that women with fertility needs be examined as early as possible to avoid adverse outcomes.

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The Relationship Between Lipoproteins and Insulin Sensitivity in Youth With Obesity and Abnormal Glucose Tolerance

Cited by 12 publications

References 48 publications

The link between vitamin D, chemerin and metabolic profile in overweight and obese children - preliminary results

The link between vitamin D, chemerin and metabolic profile in overweight and obese children - preliminary results

Lipids, apolipoproteins and gestational diabetes mellitus: a Mendelian randomization study

A study examining the correlation between serum 25-OH-VitD levels, CD3-CD19+ B lymphocytes, and the risk of early spontaneous abortion in pregnant women

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