The Relationship between Leptin Concentration and Bone Metabolism in the Human Fetus

Ogueh, Onome; Sooranna, Suren R.; Nicolaides, Kypros H.; Johnson, Mark R.

doi:10.1210/jcem.85.5.6591

Cited by 61 publications

(33 citation statements)

References 10 publications

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“…A (carboxy-terminal telopeptide type I collagen), que é um marcador de reabsorção óssea, sugerindo que a leptina provavelmente diminui a reabsorção óssea, com conseqüente aumento da massa óssea 21 . Christou et al 22 observaram que o peso ao nascer apresenta uma associação independente dos níveis de IGF-I com as concentrações de leptina do cordão, sugerindo que a leptina esteja envolvida em mecanismos ainda desconhecidos de regulação do crescimento fetal.…”

Section: Discussionunclassified

Leptin as a marker of sexual dimorphism in newborn infants

I.M.C.G.¹,

Geloneze²,

Tambascia³

et al. 2004

J Pediatr (Rio J)

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Fonte financiadora: Fundação de Amparo à Pesquisa do Estado de São Paulo -FAPESP.Artigo submetido em 17.12.03, aceito em 26.04.04. AbstractObjective: To determine cord blood leptin levels in newborns appropriate for gestational age, according to gender, birth weight, birth height and ponderal index.Methods: A cross-sectional study was carried out with 132 term newborns appropriate for gestational age (68 females, 64 males), gestational age between 35-42 weeks. Data were collected through interviews with the mothers at the maternity, anthropometrycal study of the newborns, and cord blood estradiol, testosterone and leptin assays obtained immediately after birth.Results: The levels of leptin were significantly higher in females than in males (8.34±0.65 ng/ml versus 6.06±0.71 ng/ml; p = 0.000). The concentrations of estradiol and testosterone did not differ between males and females. Leptin levels were positively correlated with gestational age (r = 0.394, p < 0.01), birth weight (r = 0.466, p < 0.01), birth length (r = 0.335, p < 0.01) and ponderal index (r = 0.326, p < 0.01).Conclusions: Leptin concentration in the umbilical cord is positively correlated with gestational age, birth weight, birth height, and ponderal index, suggesting its participation in the neonatal growth process. In addition, a gender difference with higher levels of leptin in females neonates was observed, suggesting that the sexual dimorphism in relation to body composition already exists in newborns. ResumoObjetivo: Avaliar os níveis de leptina do cordão umbilical em recém-nascidos adequados para a idade gestacional conforme sexo, peso, comprimento e índice ponderal de nascimento.Método: Estudo tipo transversal, envolvendo 132 recém-nascidos adequados para idade gestacional (68 do sexo feminino, 64 do sexo masculino), com idade gestacional de 35-42 semanas. Os dados foram obtidos mediante entrevista com as mães na maternidade, pelo estudo antropométrico dos recém-nascidos e pela dosagem de leptina, estradiol e testosterona no cordão umbilical por meio da coleta imediata após o parto.Resultados: Os recém-nascidos do sexo feminino apresentaram níveis de leptina significativamente maiores que os do sexo masculino (8,34±0,65 ng/ml versus 6,06±0,71 ng/ml; p = 0,000). Os níveis de estradiol e testosterona não variaram conforme o sexo. A leptina se correlacionou positivamente com idade gestacional (r = 0,394, p < 0,01), peso (r = 0,466, p < 0,01), comprimento (r = 0,335, p < 0,01) e índice ponderal (r = 0,326, p < 0,01) dos recém-nascidos.Conclusões: A leptina do cordão umbilical se correlaciona positivamente com idade gestacional, peso, comprimento e índice ponderal do recém-nascido, sugerindo sua participação no processo de crescimento neonatal. Além disso, os recém-nascidos do sexo feminino têm níveis séricos de leptina maiores que os do sexo masculino, sugerindo que o dimorfismo sexual relacionado à composição corporal já possa existir em recém-nascidos. ARTIGO ORIGINAL IntroduçãoA leptina (palavra grega leptos, que significa magro ) é uma p...

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Section: Discussionunclassified

Leptin as a marker of sexual dimorphism in newborn infants

I.M.C.G.¹,

Geloneze²,

Tambascia³

et al. 2004

J Pediatr (Rio J)

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“…Increasing evidence indicates that leptin may play a role in fetal bone metabolism (Ogueh et al 2000). Leptin has also been shown to have a potential role in endochondral ossification (Kume et al 2002) and furthermore leptin reduces ovariectomy-induced bone loss in rats (Burguera et al 2001).…”

Section: Discussionmentioning

confidence: 99%

Affected skeletal growth but normal bone mineralization in rat offspring after prenatal dexamethasone exposure

Swolin-Eide¹,

Dahlgren²,

Nilsson³

et al. 2002

Journal of Endocrinology

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Events occurring early in life or prenatally are able to play important roles in the pathogenesis of diseases in adult life. Different sorts of stress or hormonal influences, during particular periods of pregnancy, may result in persisting or transient changes in physiology. Glucocorticoids are used for the treatment of a variety of diseases, to promote organ maturation and to prevent preterm delivery. Glucocorticoids are also known to affect skeletal growth and adult bone metabolism. The aim of the present study was to investigate whether exposure to dexamethasone (Dex) during fetal life has any effect on skeletal growth and/or bone mineral density in adult rat offspring.Pregnant rats were given injections of either Dex (100µg/kg) or vehicle on days 9, 11 and 13 of gestation. Dex-exposed male but not female rat offspring showed transient increases in crown-rump length and tibia and femur lengths at 3-6 weeks of age. In contrast, the cortical bone dimensions were altered in 12-week-old female but not male Dex-exposed offspring. The areal bone mineral densities of the long bones and the spine, as determined by dual X-ray absorptiometry, and trabecular as well as cortical volumetric bone mineral density, as measured using peripheral quantitative computerized tomography, were unchanged in both male and female Dex-exposed offspring.In conclusion, prenatal Dex exposure affects skeletal growth in a gender-specific manner, while the mineralization of bones is unaffected in both male and female offspring.

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“…For example, an inverse relationship between the cross-linked carboxyterminal telopeptide of type 1 collagen (CTX), a marker of bone resorption, and leptin concentrations in foetal blood has been detected. 92 Furthermore, a positive correlation between bone mass and serum leptin levels was observed in non-obese women after adjustment for body weight and fat mass. 93 On the other hand, leptin-deficient ob/ob mice have a high bone mass.…”

Section: Bone Mineral Densitymentioning

confidence: 92%

The role of leptin in anorexia nervosa: clinical implications

et al. 2006

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Leptin is a hormone with pleiotropic functions affecting several tissues. Because leptin has a crucial role in the adaptation of an organism to semi-starvation, anorexia nervosa (AN) serves as a model disorder to elucidate the functional implications of hypoleptinaemia; vice versa, several symptoms in patients with this eating disorder are related to the low leptin levels, which are characteristic of acute AN. Weight gain in AN patients can induce relative hyperleptinaemia in comparison to controls matched for body mass index; circulating leptin concentrations in AN patients thus transverse from subnormal to supranormal levels within a few weeks. We review findings on leptin secretion in AN and focus on implications, particularly for the hypothalamus-pituitary-gonadal axis, bone mineral density and physical hyperactivity. Undoubtedly, the elucidation of leptin's function as a trigger of diverse neuroendocrine adaptations to a restricted energy intake has substantially advanced our knowledge of the pathogenesis of distinct symptoms of AN, including amenorrhoea that represents one of the four diagnostic criteria. The fact that hypoleptinaemia can induce hyperactivity in a rat model for AN has led to a series of studies in AN patients, which support the notion that application of leptin to severely hyperactive patients might prove beneficial.

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The Relationship between Leptin Concentration and Bone Metabolism in the Human Fetus

Cited by 61 publications

References 10 publications

Leptin as a marker of sexual dimorphism in newborn infants

Leptin as a marker of sexual dimorphism in newborn infants

Affected skeletal growth but normal bone mineralization in rat offspring after prenatal dexamethasone exposure

The role of leptin in anorexia nervosa: clinical implications

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