The Relationship between Lectin-Like Oxidized Low-Density Lipoprotein Receptor-1 Ligands Containing Apolipoprotein B and the Cardio-Ankle Vascular Index in Healthy Community Inhabitants: The KOBE Study

Sugiyama, Daisuke; Higashiyama, Aya; Wakabayashi, Ichiro; Kubota, Yoshimi; Adachi, Yoshiko; Hayashibe, Akiko; Kawamura, Kuniko; Kuwabara, Kazuyo; Nishimura, Kunihiro; Kadota, Aya; Nishida, Yoko; Hirata, Takumi; Imano, Hironori; Miyamatsu, Naomi; Miyamoto, Yoshihiro; Sawamura, Tatsuya; Okamura, Tomonori

doi:10.5551/jat.26450

Cited by 17 publications

(13 citation statements)

References 30 publications

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“…Besides uptake through scavenger receptors on macrophages and foam cell formulation in vessel walls, ox-LDL has recently been found to exert other pro-atherogenic effects through LOX-1 22 ) . LOX-1 is the major ox-LDL receptor on the surface of endothelial cells, resulting in endothelial dysfunction, vessel cell proliferation, and thrombogenesis 2 , 23 – 25 ) . Our finding that higher circulating ox-LDL levels were associated with subclinical atherosclerosis, independent of other LDL-related parameters, supports the presence of these pro-atherogenic pathways.…”

Section: Discussionmentioning

confidence: 99%

Circulating Oxidized Low-Density Lipoprotein Levels Independently Predict 10-Year Progression of Subclinical Carotid Atherosclerosis: A Community-Based Cohort Study

Gao

Zhao

et al. 2018

J Atheroscler Thromb

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Aims: To investigate the association between circulating oxidized low-density lipoprotein (ox-LDL) levels and progression of subclinical atherosclerosis and to examine whether this link is independent of other low-density lipoprotein (LDL)-related parameters.Methods: Totally, 804 subjects who were free of cardiovascular disease at baseline completed risk factor surveys and carotid ultrasound measurements in 2002 and 2012. Modified Poisson regression was performed to examine the association between baseline serum ox-LDL levels and the 10-year risk of progression of carotid atherosclerosis which was defined as the development of at least one new plaque in a previously plaque-free carotid segment at re-examination.Results: The mean age of the subjects was 58.6 ± 7.7 years at baseline and 43.3% were men. A total of 504 (62.7%) subjects had carotid plaque progression at re-examination. Subjects in the intermediate and highest tertiles of ox-LDL had a significantly higher adjusted risk of atherosclerosis progression than those in the lowest tertile [relative risk (95% confidence interval) 1.17 (1.01–1.34) for the intermediate tertile and 1.23 (1.07–1.42) for the highest tertile]. This association was independent of baseline levels of LDL-C, total LDL particle number, and small LDL particle number.Conclusion: This study demonstrates that serum ox-LDL levels predict 10-year progression of subclinical atherosclerosis. Moreover, this effect is independent of the cholesterol content, the number, and the size of LDL particles.

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Section: Discussionmentioning

confidence: 99%

Circulating Oxidized Low-Density Lipoprotein Levels Independently Predict 10-Year Progression of Subclinical Carotid Atherosclerosis: A Community-Based Cohort Study

Gao

Zhao

et al. 2018

J Atheroscler Thromb

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“…However, some guidelines recommend the use of non-high-density lipoprotein cholesterol (non-HDL-C) when triglyceride (TG) levels are high or as a secondary target after achieving the management target for low-density lipoprotein cholesterol (LDL-C) 4,6) . Non-HDL-C is a simple measure calculated by subtracting high-density lipoprotein neoplasm or cardiovascular disease; were not receiving treatment for hypertension, diabetes mellitus, or dyslipidemia; and were subjectively healthy based on selfreported result [15][16][17][18] . Between July 2010 and December 2011, 1,134 individuals were included in the baseline survey.…”

Section: Introductionmentioning

confidence: 99%

Relationship between Non-High-Density Lipoprotein Cholesterol and Low-Density Lipoprotein Cholesterol in the General Population:

Kuwabara

Harada

Sugiyama

et al. 2016

JAT

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Aim:The Japan Atherosclerosis Society (JAS) Guidelines for Diagnosis and Prevention of Atherosclerotic Cardiovascular Diseases for Japanese 2012 version have set a non-high-density lipoprotein cholesterol (non-HDL-C)-management target of low-density lipoprotein cholesterol (LDL-C) 30 mg/ dL. However, the actual difference between non-HDL-C and LDL-C is not clear. Therefore, we evaluated its joint distribution and assessed the validity of this criterion in the general Japanese population. Methods: We used baseline cross-sectional data of 4,110 participants from two studies; the KOBE Study (n 1,108) and the Tsuruoka Metabolomic Cohort Study (n 3,002). To evaluate whether the difference between LDL-C and non-HDL-C in the general population match that of the current guidelines, we classified LDL-C levels into four groups according to the JAS Guideline and evaluated its agreement with the corresponding non-HDL-C group. Analysis was also done using six groups (the previous four groups plus the upper and lower cut-off values). Results: The mean difference (mg/dL) between the non-HDL-C and LDL-C (for the KOBE Study and Tsuruoka Metabolomic Cohort Study, respectively) was 19.6 and 24.1 (p 0.001) for men and 15.9 and 18.3 (p 0.001) for women. In both the cohort studies, the difference was lower than 30 mg/dL. It was especially small among individuals with normal triglyceride levels. Conclusions: In the general Japanese population, the difference between non-HDL-C and LDL-C was lower than the expected difference of 30 mg/dL. Changes to the criteria for non-HDL-C target levels may be considered in the future.

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“… 19 In fact, circulating LAB was positively associated with the CAVI, a marker of arterial stiffness, in men. 33 Furthermore, circulating LAB, but not sLOX-1, is reportedly associated with the risk of cardiovascular disease and ischemic stroke. 34 The reason for the potential positive association between ANGPTL2 and LAB confirmed in this study is not fully apparent.…”

Section: Discussionmentioning

confidence: 99%

Association between angiopoietin-like protein 2 and lectin-like oxidized low-density lipoprotein receptor 1 ligand containing apolipoprotein B in patients with type 2 diabetes

et al. 2018

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ObjectiveThis study was performed to evaluate the association of the serum level of angiopoietin-like protein 2 (ANGPTL2) with circulating inflammatory markers and oxidized and modified low-density lipoprotein (LDL) cholesterol as evaluated by lectin-like oxidized LDL receptor 1 ligand containing apolipoprotein B (LAB) in patients with type 2 diabetes.MethodsThe study included 70 patients with type 2 diabetes hospitalized for glycemic control and 9 control subjects.ResultsThe serum level of ANGPTL2 was significantly higher in the patients with type 2 diabetes than in the healthy controls. There was a significant positive correlation between ANGPTL2 and the high-sensitivity C-reactive protein, fibrinogen, and LAB levels and a significant negative correlation between ANGPTL2 and the estimated glomerular filtration rate (eGFR).ConclusionsThese results suggest that the serum ANGPTL2 level has a close positive association with inflammatory markers, especially fibrinogen and oxidized and modified LDL as evaluated by LAB. The data also suggest that the serum ANGPTL2 level is influenced by renal function as reflected by the eGFR.

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The Relationship between Lectin-Like Oxidized Low-Density Lipoprotein Receptor-1 Ligands Containing Apolipoprotein B and the Cardio-Ankle Vascular Index in Healthy Community Inhabitants: The KOBE Study

Abstract: Original Article rosis; the oxidative modification of low-density lipoprotein (LDL) is considered to play a key role in endothelial dysfunction 1) . Lectin-like oxidative LDL receptor-1 (LOX-1) is the receptor for oxidative and/

Cited by 17 publications

References 30 publications

Circulating Oxidized Low-Density Lipoprotein Levels Independently Predict 10-Year Progression of Subclinical Carotid Atherosclerosis: A Community-Based Cohort Study

Circulating Oxidized Low-Density Lipoprotein Levels Independently Predict 10-Year Progression of Subclinical Carotid Atherosclerosis: A Community-Based Cohort Study

Relationship between Non-High-Density Lipoprotein Cholesterol and Low-Density Lipoprotein Cholesterol in the General Population:

Association between angiopoietin-like protein 2 and lectin-like oxidized low-density lipoprotein receptor 1 ligand containing apolipoprotein B in patients with type 2 diabetes

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