The relationship between lavender and tea tree essential oils and pediatric endocrine disorders: A systematic review of the literature

Hawkins, Jessie; Hires, Christy; Dunne, Elizabeth; Baker, Colby

doi:10.1016/j.ctim.2019.102288

Cited by 22 publications

(15 citation statements)

References 34 publications

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“…Despite the great interest in TTO reported in the last years 54 , 55 , the contribution of TTO as a sensitizer of cancer, and in particular, of melanoma therapy 56 , 57 , is unknown. We demonstrated that TTO synergized with dabrafenib and trametinib, when administered either as single agents or in combination, in terms of apoptosis induction, when TTO treatment was followed by exposure to one of the two drugs.…”

Section: Discussionmentioning

confidence: 99%

Antitumor effect of Melaleuca alternifolia essential oil and its main component terpinen-4-ol in combination with target therapy in melanoma models

et al. 2021

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Essential oils (EOs) have been recently emerging for their promising biological activities in preventing tumorigenesis or progression of different tumor histotypes, including melanoma. In this study, we investigated the antitumor activity of a panel of EOs in different tumor models. The ability of Melaleuca alternifolia (tea tree oil) and its main component, terpinen-4-ol, to sensitize the target therapy currently used for melanoma treatment was also assessed. Our results demonstrated that EOs differently affect the viability of human cancer cells and led us to select six EOs effective in melanoma and lung cancer cells, without toxic effects in human fibroblasts. When combined with dabrafenib and/or trametinib, Melaleuca alternifolia synergistically reduced the viability of melanoma cells by activating apoptosis. Through machine learning classification modeling, α-terpineol, tepinolene, and terpinen-4-ol, three components of Melaleuca alternifolia, were identified as the most likely relevant components responsible for the EO’s antitumor effect. Among them, terpinen-4-ol was recognized as the Melaleuca alternifolia component responsible for its antitumor and proapoptotic activity. Overall, our study holds promise for further analysis of EOs as new anticancer agents and supports the rationale for their use to improve target therapy response in melanoma.

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Section: Discussionmentioning

confidence: 99%

Antitumor effect of Melaleuca alternifolia essential oil and its main component terpinen-4-ol in combination with target therapy in melanoma models

et al. 2021

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“…Furthermore, the frequency and duration of exposure to LO inhalation are highly variable, and the effect of LO following skin exposure on children remains inconclusive because of the variable amounts of LO to which the skin is exposed, and difficulties associated with follow-up to assess long-term effects. 36 …”

Section: Discussionmentioning

confidence: 99%

Association of Early Pubertal Onset in Female Rats With Inhalation of Lavender Oil

Kim

Lim

2022

J Korean Med Sci

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Background Central precocious puberty (CPP) is caused by early activation of the hypothalamic–pituitary–gonadal axis but its major cause remains unclear. Studies have indicated an association between chronic environmental exposure to endocrine-disrupting chemicals and pubertal onset. Essential oil is widely used in homes worldwide for relief of respiratory symptoms, stress, and/or sleep disturbance. Methods To evaluate this association, we compared the hormone levels and timing of vaginal opening (VO) in female rats exposed to lavender oil (LO) through different routes (study groups: control, LO nasal spray [LS], and indoor exposure to LO [LE]) during the prepubertal period. The body weights of the animals were also compared every 3 days until the day of VO, at which time gonadotropin levels and internal organ weights were assessed. Results The LS group showed early VO at 33.8 ± 1.8 days compared with the control (38.4 ± 2.9 days) and LE (36.6 ± 1.5 days) groups. Additionally, luteinizing hormone levels were significantly higher in the LE and LS groups than those in the control group. Body weights did not differ significantly among the groups. Conclusion Inhalation exposure to an exogenic simulant during the prepubertal period might trigger early pubertal onset in female rats. Further evaluation of exposure to other endocrine-disrupting chemicals capable of inducing CPP through the skin, orally, and/or nasally is warranted.

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“…Nevertheless, inhalation of environmental LO is di cult to quantify in humans, and epidemiological surveillance data for the sole effect of LO inhalation in children undergoing precocious puberty are unavailable. Furthermore, the frequency and duration of exposure to LO inhalation are highly variable, and the effect of LO following skin exposure on children remains inconclusive because of the variable amounts of LO to which the skin is exposed, and di culties associated with follow-up to assess longterm effects (24).…”

Section: Discussionmentioning

confidence: 99%

Association of Early Pubertal Onset in Female Rats with Inhalation of Lavender Oil

Kim

Lim

2021

Preprint

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Background Central precocious puberty is caused by early activation of the hypothalamic–pituitary–gonadal axis but its major cause remains unclear. Studies have indicated an association between chronic environmental exposure to endocrine-disrupting chemicals and pubertal onset. Methods To evaluate this association, we compared the hormone levels and timing of vaginal opening in female rats exposed to lavender oil (LO) through different routes [study groups: control, LO nasal spray (LS), and indoor exposure to LO (LE)] during the prepubertal period. The body weights of the animals were also compared every 3 days until the day of vaginal opening, at which time gonadotropin levels and internal organ weights were assessed. Results The LS group showed early vaginal opening at 33.8 ± 1.8 days compared with the control (38.4 ± 2.9 days) and LE (36.6 ± 1.5 days) groups. Additionally, luteinizing hormone levels were significantly higher in the LE and LS groups than in the control group. Body weights did not differ significantly among the groups. Conclusions Exposure to an exogenic simulant via inhalation during the prepubertal period triggered early puberty onset in female rats. Further evaluation of exposure to other endocrine-disrupting chemicals capable of inducing central precocious puberty through the skin, orally, and/or nasally is warranted.

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The relationship between lavender and tea tree essential oils and pediatric endocrine disorders: A systematic review of the literature

Cited by 22 publications

References 34 publications

Antitumor effect of Melaleuca alternifolia essential oil and its main component terpinen-4-ol in combination with target therapy in melanoma models

Antitumor effect of Melaleuca alternifolia essential oil and its main component terpinen-4-ol in combination with target therapy in melanoma models

Association of Early Pubertal Onset in Female Rats With Inhalation of Lavender Oil

Association of Early Pubertal Onset in Female Rats with Inhalation of Lavender Oil

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