The relationship between knowledge of family history and cancer characteristics at diagnosis in women newly-diagnosed with invasive breast cancer

Lijovic, Marijana; Davis, Susan Ruth; Fradkin, Pam; Bradbury, Joan; China, Maria La; Schwarz, M. A.; Wolfe, Rory; Farrugia, Helen; Bell, Robin Jean

doi:10.1007/s10689-009-9236-x

Cited by 8 publications

(8 citation statements)

References 24 publications

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“…In contrast to others studies we could not demonstrate a difference in clinical, histopathological or treatment characteristics between those with one or more FDR vs. none [21][22][23][24]. In women with 2 FDR we noted a lower incidence of lymph node metastases, and less adjuvant systemic therapy seemed associated with a positive FH (p40.05).…”

Section: Discussioncontrasting

confidence: 99%

Long-term effects of first degree family history of breast cancer in young women: Recurrences and bilateral breast cancer

et al. 2015

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Background. The aim of this study is to analyze the impact of first degree relative (FDR) of young breast cancer patients. Methods. Data were used from our prospective population-based cohort study which started in 1983. The family history (FH) was registered with regard to FDR: the presence or absence of invasive breast cancer in none vs. one or more FDRs at any age. Results. A total of 1109 women, 50 years with 1128 breast conserving treatments was seen. The incidence of FDR was 17.0% for one FDR and 3.2% 2 FDR. The three groups, none, 1 or 2 FDR, were comparable. The local failure rate is comparable for all three groups. Women with a positive FH and metachronous bilateral breast cancer (MBBC) showed a lower local failure (HR 0.2; 95% CI 0.05-0.8). A positive FH was an independent predictor for a better disease-specific survival (HR 0.6; 95% CI 0.4-0.9). Conclusion. A positive FH, based on FDR implies a better prognosis in relation to survival for young women treated with BCT. In contrast to no FH for FDR, MBBC in women with a positive FH was not associated with an increased risk of local recurrence.

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Section: Discussioncontrasting

confidence: 99%

Long-term effects of first degree family history of breast cancer in young women: Recurrences and bilateral breast cancer

et al. 2015

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“…Furthermore, the authors found that BC death in a family is a stronger predictor for the use of BC screening. Our results confirm the findings of recent studies, which showed that women with affected first-degree relatives were more likely to have smaller carcinomas and more often early disease stage [7][8][9]. Furthermore, our study confirms data from other studies which showed no significant differences with regard to tumor size and stage between patients who had only second-degree relatives affected with BC and patients without FH for BC [7,8].…”

Section: Tumor Size (Table 2 and 5)supporting

confidence: 92%

“…During the last decade, there have only been a few studies which evaluated the impact of FH on BC detection and tumor size in BC patient cohorts [7][8][9]. However, most of them reported only data on tumor size and stage [7], or tumor size and pathological/biological features [9] but did not consider tumor detection method. Malone et al [8] applied a more comprehensive approach and reported both tumor size/stage and detection method.…”

Section: Strengths and Limitationsmentioning

confidence: 99%

“…During the last decade, there have only been a few studies which evaluated the impact of FH on BC detection and tumor size in BC patient cohorts [7][8][9]. To our knowledge, our study is the first comprehensive analysis of the impact of FH on BC detection and tumor size based on a more recent population-based cohort (1990-2009) which does not exclusively consider a subgroup of younger BC patients [8], but rather also analyzes women at an age in which BC mainly occurs (women up to and including 70 years of age).…”

Section: Introductionmentioning

confidence: 99%

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Impact of breast cancer family history on tumor detection and tumor size in women newly-diagnosed with invasive breast cancer

Schwab

Bürki²,

Huang

et al. 2013

Familial Cancer

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This study evaluated the impact of family history (FH) on tumor detection, the patient's age and tumor size at diagnosis in breast cancer (BC). Furthermore, we investigated whether the impact of FH on these features was dependent on degree of relationship, number of relatives with a BC history, or the age of the affected relative at the time that her BC was diagnosed. Out of the entire cohort (n = 1,037), 244 patients (23.5%) had a positive FH; 159 (15.3%) had first-degree relatives affected with BC and 85 patients (8.2%) had second-degree affected relatives. Compared to women who had no BC-affected relatives, the tumors of women who had positive FH were more often found by radiological breast examination (RBE: 31.7%/27.2%, p = 0.008), and they were smaller (general tumor size: 21.8 mm/26.4 mm, p = 0.003; size of tumors found by breast self-examination (BSE): 26.1 mm/30.6 mm, p = 0.041). However, this positive effect of increased use of BC screening and smaller tumor sizes was only observed in patients whose first-degree relatives were affected (comparison with second-degree affected relatives: RBE: 43.8%/24.7%; odds ratio 2.38, p = 0.007; general tumor size: 19.3 mm/26.3 mm; mean difference (MD) -6.9, p = 0.025; tumor size found by BSE: 22.5 mm/31.0 mm; MD -8.5, p = 0.044). When more second-degree relatives or older relatives were diagnosed with BC, the tumors of these patients were similarly often detected by RBE (relationship: 24.7%/27.2%, p = 0.641; age: 33.7 %/27.2 %, p = 0.177) and had similar tumor sizes (general size: 26.3 mm/26.4 mm, p = 0.960; BSE: 31.0 mm/30.6 mm, p = 0.902) as those of women without a FH. Women with a positive FH generally use mammography screening more often and perceive changes in the breast earlier than women without such history. The increased awareness of BC risk decreases if the relationship is more distant.

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“…The authors add follow-up considerations for better representations of the illness and coping mechanisms in order to influence the entire family system (family cohesion and family satisfaction) [28]. Other studies proved that the belief that the illness was part of family history could determine or maintain certain behaviors with negative consequences on the individual's health [29–31]. The direct connection between a high level of family cohesion and a patient's functional, adaptive representation of the disease supports the fact that, for patients with a family history of cancer, therapeutic intervention must address both patients and their families, in order to build balanced, functional systems within these families.…”

Section: Discussionmentioning

confidence: 99%

Cognitive-Behavioral Coping, Illness Perception, and Family Adaptability in Oncological Patients with a Family History of Cancer

Postolica

Iorga

Petrariu

et al. 2017

BioMed Research International

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Aim. The study investigated the differences between patients with and without a family history of cancer regarding coping strategies, illness perception, and family adaptability to the disease. Material and Methods. A total of 124 patients diagnosed with cancer were included in the research (55 of them with a family history of cancer). The Cognitive Emotion Regulation Questionnaire, the Strategic Approach to Coping Scale, the Family Adaptability and Cohesion Scale, and the Illness Perception Questionnaire were applied. The data were processed using the SPSS 21 software. Results. Patients with previous records of cancer in the family get significantly higher scores for the illness coherence factor. Family satisfaction is significantly higher for patients with a genetic risk, compared to the one reported by patients who suffer from the disease but have no genetic risk. Cognitive-behavioral coping strategies and family cohesion are factors that correlate with an adaptive perception of the illness in the case of patients with a family history of cancer. Conclusion. Results are important for the construction of strategies used for patients with a family history of cancer.

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The relationship between knowledge of family history and cancer characteristics at diagnosis in women newly-diagnosed with invasive breast cancer

Abstract: Women with a first degree relative with BC had smaller, earlier stage cancers at diagnosis, possibly reflecting more diligent use of breast screening amongst women who considered themselves at increased risk of developing the disease.

Cited by 8 publications

References 24 publications

Long-term effects of first degree family history of breast cancer in young women: Recurrences and bilateral breast cancer

Long-term effects of first degree family history of breast cancer in young women: Recurrences and bilateral breast cancer

Impact of breast cancer family history on tumor detection and tumor size in women newly-diagnosed with invasive breast cancer

Cognitive-Behavioral Coping, Illness Perception, and Family Adaptability in Oncological Patients with a Family History of Cancer

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