The Relationship Between Iodine Excess and Thyroid Function During Pregnancy and Infantile Neurodevelopment at 18–24 Months

Wu, Wen Shu; Chen, Yanting; Guo, Wenxing; Zhang, Kexin; Fu, Ming; Pan, Ziyun; Yang, Ying; Zhang, Naifan; Zhang, Wanqi

doi:10.1016/j.tjnut.2023.05.012

Cited by 3 publications

(4 citation statements)

References 27 publications

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“…The study by Abel et al has found that low maternal iodine intake linked to poorer language, reading, writing (13). We identified research suggesting that excessive iodine intake may also have adverse effects on infantile neurodevelopment (30). Abel et al (13) and Murcia et al (16) found no association between iodine supplementation during pregnancy and neurodevelopment.…”

Section: • Pufasmentioning

confidence: 72%

“…Focused Areas of Research: The primary emphasis of the included studies was on the interrelation between maternal diet or nutrition during pregnancy and its subsequent effects on child neurodevelopment. In the publications we have examined, the effects on offspring neurodevelopment from the maternal intake or status of polyunsaturated fatty acids (PU-FAs) (11,18,24,25), folate (22,26,27), vitamin D (28,29), iodine (13,16,30), and iron ( 14) have been studied. Several studies have assessed the impact of the mother's dietary pattern (15,20,23), her BMI (12,17,19,31,32), and microbiota (12).…”

Section: Studymentioning

confidence: 99%

“…The Food Frequency Questionnaire (FFQ) emerged as a common tool for dietary pattern assessment across studies (15,18,20,22,35). Other methods used to assess the nutrition of the pregnant woman and her nutritional status was 24-hour dietary recall (27), dietary questionnaire (19,22,26,31), serum ferritin levels (14), blood samples for folate (27), for PUFAs (25), thyroid hormones measurement (30,35), 25(OH) D plasma concentration (28), 25(OH)D in cord blood (29), urinary iodine concentration (UIC) (16,30). We identified a study on the effect of consuming ultra-processed foods (UPF) during pregnancy on child neurodevelopment (21).…”

Section: Assessment Of Maternal Nutrition and Nutritional Statusmentioning

confidence: 99%

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Impact of Maternal Nutrition on Child Neurodevelopment: Insights from Recent Studies

Chamova,

Toneva,

Brajkova

et al. 2023

Biomedical Reviews

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Background:The initial 1000 days of human life, from conception to two years of age, are crucial for health growth and neuropsychological development. This period's primary environmental influence is maternal nutrition, which significantly impacts the development of the fetal nervous system. Objectives: This review aims to synthesize current literature on the effects of dietary patterns and nutritional status of pregnant women on the neurodevelopment of their offspring. Methods: Adhering to the Scale for the Quality Assessment of Narrative Review Articles (SANRA) and elements of the PRISMA guidelines, we conducted a systematic literature search in electronic databases including PubMed, Scopus, and Mendeley, focusing on publications from 2018 to 2023. Results: Our review encapsulates findings from 25 peer-reviewed articles, highlighting the influence of various nutrients like polyunsaturated fatty acids (PUFAs), vitamin D, folate, iodine, and iron on child neurodevelopment. Studies also examined the effects of maternal dietary patterns, body mass index (BMI), and alcohol exposure. Key findings indicate the crucial role of balanced maternal nutrition in optimal neurodevelopmental outcomes in children. Discussion: The review reveals intricate relationships between maternal dietary habits, supplementation, and child growth and neurological development. While some nutrients show clear benefits, others present mixed findings, underlining the complexity of maternal nutrition's role in child development. Conclusion:The review underscores the importance of balanced maternal nutrition for favorable neurodevelopmental outcomes in offspring, calling for more detailed research to understand the nuanced roles of specific nutrients and dietary patterns. Biomed Rev 2023; 34: 109-119

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Section: • Pufasmentioning

confidence: 72%

Section: Studymentioning

confidence: 99%

Section: Assessment Of Maternal Nutrition and Nutritional Statusmentioning

confidence: 99%

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Impact of Maternal Nutrition on Child Neurodevelopment: Insights from Recent Studies

Chamova,

Toneva,

Brajkova

et al. 2023

Biomedical Reviews

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“…Risk of fine motor developmental delay was increased in infants with maternal TSH ≥2.5 mIU/l during pregnancy (OR: 4.32; 95% CI: 1.43–13.0). Wu et al concluded that maternal iodine status above requirement during pregnancy negatively affected infant neurodevelopment [37 ▪▪ ]. Another prospective study of 699 mother–infant pairs from Australia showed that mean (SD) iodine intake during pregnancy was similar at 16 (study entry) and 28 weeks, 308 (120) μg/day, with 82% of women taking iodine supplements.…”

Section: Pregnant Womenmentioning

confidence: 99%

Impact of iodine supply in infancy and childhood

Turck

2024

Current Opinion in Clinical Nutrition &Amp; Metabolic Care

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Purpose of review To assess the most relevant articles on the impact of iodine supply in at-risk populations, namely infants and young children, pregnant and lactating women. Recent findings The 2022 Iodine Global Network Annual Report confirmed the dramatic decrease of severe iodine deficiency over the last 30 years, thanks to universal iodine iodization. However, mild to moderate deficiency is still present in many countries, where recent data showed a decrease of iodine intake and an impairment of iodine status. Unfortunately, there is yet no validated biomarker to classify the iodine status at the individual level. Available data show that there is no clear evidence to link mild-to-moderate iodine deficiency to adverse health outcomes in pregnant and lactating women as well as in infants and children. The description of a negative impact of maternal iodine excess on neurodevelopment of infants is of concern. Summary Optimization of salt iodization (e.g. careful increase in iodine concentration in salt, use by food industry in processed foods) combined with targeted, personalized supplementation under medical supervision if needed (e.g. low intake of iodine rich foods, vegan diet) seems currently preferable to blanket supplementation.

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Risks of Iodine Excess

Sohn,

Inoue,

Rhee

et al. 2024

Endocrine Reviews

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Iodine is a micronutrient that is required for thyroid hormone synthesis. The iodide cycle in thyroid hormone synthesis consists of a series of transport, oxidation, organification, and binding/coupling steps in thyroid follicular cells. Common sources of iodine include the consumption of an iodine-rich diet or iodine-fortified foods, the administration of amiodarone, iodine-containing supplements, or iodinated contrast media, and other miscellaneous sources. Methods to assess population iodine status include the measurement of urinary iodine concentrations, blood thyroglobulin levels, prevalence of elevated neonatal thyrotropin levels, and thyroid volume. Although excessive iodine intake or exposure is generally well tolerated, an acute iodine load may result in thyroid dysfunction (hypothyroidism or hyperthyroidism) in certain susceptible individuals due to the failure to escape from the Wolff–Chaikoff effect and to the Jod–Basedow phenomenon, respectively. In this review, we discuss the associations between excessive iodine intake or exposure, with particular focus on iodinated contrast media as a common source of excess iodine in health care settings, and risks of incident thyroid dysfunction. We also summarize the risks of iodine excess in vulnerable populations and review current guidelines regarding the screening and monitoring of iodinated contrast–induced thyroid dysfunction. Finally, we discuss the long-term potential nonthyroidal health risks associated with iodine excess and suggest the need for more data to define safe upper limits for iodine intake, particularly in high-risk populations.

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The Relationship Between Iodine Excess and Thyroid Function During Pregnancy and Infantile Neurodevelopment at 18–24 Months

Cited by 3 publications

References 27 publications

Impact of Maternal Nutrition on Child Neurodevelopment: Insights from Recent Studies

Impact of Maternal Nutrition on Child Neurodevelopment: Insights from Recent Studies

Impact of iodine supply in infancy and childhood

Risks of Iodine Excess

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