The Relationship Between Inflammatory Reagents and Mortality in Patients Over the Age of 55 Hospitalised in the Internal Medicine Intensive Care Unit from the Emergency Service

Uluoz, Hasim Onur; Sebe, Ahmet; Ay, Mehmet Oğuzhan; Topal, Yagmur; Açıkalın, Ayça; Gülen, Müge; Acehan, Selen

doi:10.5152/jaem.2013.009

Cited by 4 publications

(1 citation statement)

References 37 publications

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“…It is an acutephase reactant and its serum level decreases with inflammation [19]. Studies have shown that there is a relationship between low albumin levels and mortality [20,21]. The ratio of CRP/albumin, which is used as a new inflammation parameter, is thought to be more related to severity of inflammation relative to albumin or CRP alone [22].…”

Section: Discussionmentioning

confidence: 99%

The relationship between venous insufficiency and serum magnesium level

Caliskan¹,

Atay²,

Gunay-Polatkan³

et al. 2022

Magnesium Research

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Background: Magnesium is the second most common cation in the cell. In addition to its role as a cofactor in many enzymatic pathways in physiological processes, it is necessary for the regular functioning of vascular smooth muscle cells. Magnesium deficiency has been associated with exacerbation of inflammation, which plays a role in the aetiopathogenesis of many diseases. Aim: To investigate the potential relationship between serum magnesium level and the development of chronic venous insufficiency by comparison with healthy individuals. Methods: The study included 394 patients with venous insufficiency based on physical examination findings and colour Doppler ultrasonography, and 206 controls without venous insufficiency. Venous insufficiency was defined by colour Doppler as reflux lasting 0.5 seconds or more in superficial veins, and longer than one second in femoral and popliteal veins. Clinical, haematological and biochemical parameters, including serum magnesium level and indicators of inflammation, were compared between groups. Results: A total of 600 participants were included. There was no significant difference between the groups in terms of age and gender. In total, 187 (47.46%) patients with chronic venous insufficiency and 105 (50.97%) of the control group were male (p=0.414). The median age of the patients with chronic venous insufficiency was 48 (min-max: 41-49), and the median age of the control group was 49.00 (min-max: 45.00-60.25) (p=0.064). Serum magnesium level was found to be significantly lower in the group with chronic venous insufficiency compared to the control group; 1.90 mg/dL (min-max: 1.82-2) versus 2.1 mg/dL (min-max: 2-2.2) (p<0.001), respectively. Conclusion: Low serum magnesium levels may pose a potential risk for the development of chronic venous insufficiency, which is common in the community.

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Section: Discussionmentioning

confidence: 99%

The relationship between venous insufficiency and serum magnesium level

Caliskan¹,

Atay²,

Gunay-Polatkan³

et al. 2022

Magnesium Research

View full text Add to dashboard Cite

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Effect of platelet–lymphocyte ratio and lactate levels obtained on mortality with sepsis and septic shock

Bıyıklı

Kayıpmaz

Kavalcı

2018

The American Journal of Emergency Medicine

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Evaluation of predictive effect of PAF-AH on the prognosis of intensive care unit patients / Yoğun bakım hastalarında PAF-AH’ın prognoz üzerindeki prediktif etkisinin değerlendirilmesi

Taş

Bayrak

Yağan

et al. 2016

Turkish Journal of Biochemistry

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Objective: Determination of the factors associated with the intensive care unit (ICU) prognosis and mortality has important role in the clinical follow-up of the patients. Definition of novel biomarkers, beside older biomarkers available for evaluation of the outcome of these patients has been proposed. Platelet-activating factor acetylhydrolase (PAF-AH) is an enzyme that inactivates the platelet-activating factor. A reduction in the level of the PAF-AH has been demonstrated during systemic inflammation and multiple organ failure. This research aims to determine whether measurement of PAF-AH enzyme activity in ICUs can be used as a prognostic indicator like conventional biomarkers.Methods: Eighty five adult patients have been included. Following data have been recorded: preliminary C-reactive protein (CRP), lactate, albumin and PAF-AH values, APACHE II scores and discharge forms from ICU. Patients were divided in two groups with respect to APACHE II values: Group 1 (1-19) and Group 2 (≥20).Results: Observed mortality was 51.2%. In the APACHE II Group 2 patients, the values of CRP (p=0.001) and lactate (p=0.040) were significanty high, and the values of PAF-AH (p=0.008) and albumin (p=0.001) were significantly low. A statistically significant difference was found between PAF-AH values of exitus and alive patients (p=0.001). According to ROC analysis, the sensitivity and specificity of predicting mortality was 70.5% and 70.7% for CRP, 63.6% and 70.7% for lactate, 90.2% and 61.4% for albumin and 63.6% and 70% PAF-AH, respectively.Conclusion: Our study demonstrated that, in predicting the ICU mortality risk, sensitivity of the PAF-AH is similar to the sensitivity of the lactate, and specificity of the PAF-AH is better than that of the albumin. According to our results, PAF-AH can be included in the novel biomarkers.

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The Relationship Between Inflammatory Reagents and Mortality in Patients Over the Age of 55 Hospitalised in the Internal Medicine Intensive Care Unit from the Emergency Service

Cited by 4 publications

References 37 publications

The relationship between venous insufficiency and serum magnesium level

The relationship between venous insufficiency and serum magnesium level

Effect of platelet–lymphocyte ratio and lactate levels obtained on mortality with sepsis and septic shock

Evaluation of predictive effect of PAF-AH on the prognosis of intensive care unit patients / Yoğun bakım hastalarında PAF-AH’ın prognoz üzerindeki prediktif etkisinin değerlendirilmesi

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