The relationship between inflammatory bowel disease and socioeconomic variables

Bernstein, Çharles N.; Kraut, Allen; Blanchard, James; Rawsthorne, Patricia; Yu, Nancy; Walld, Randy

doi:10.1111/j.1572-0241.2001.03946.x

Cited by 122 publications

(81 citation statements)

References 15 publications

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“…Stepwise multiple logistic regression was used to determine the effects of age (15)(16)(17)(18)(19)(20)(21)(22)(23)(24)(25)(26)(27)(28)(29)(30)(31)(32)(33)(34)(35)(36)(37)(38)(39)(40)(41)(42)(43)(44), and 45-64 years), gender, educational status (less than grade 10, grade 10-12, some postsecondary schooling), area of residence (Winnipeg, non-Winnipeg urban, and rural), marital status (married and common law versus all other), ethnicity (aboriginal versus nonaboriginal), living with a fulltime employed person (yes, no), living in the same dwelling for the previous 5 years (yes, no), household income (continuous variable), previous mental health care (yes, no), suicide attempts from 1 April 1983 to 5 June 1986 (yes, no), and employment status on the likelihood of an individual attempting suicide following the census. The employment variables were divided into the following four mutually exclusive categories: full-time employed, part-time employed, unemployed, and not in the labor force.…”

Section: Discussionmentioning

confidence: 99%

“…Although we did not specifically validate this definition of attempted suicide, claimsbased definitions of various diseases, including diabetes (26) and inflammatory bowel disease (27), have been validated in previous work through the use of the linked data. In our data set of working-age noninstitutionalized persons, 112 persons attempted suicide 126 times prior to the census, and 144 persons attempted suicide 158 times in the 3.5 years following the census.…”

Section: Identification Of Attempted and Successful Suicide Casesmentioning

confidence: 99%

See 1 more Smart Citation

Influence of lack of full-time employment on attempted suicide in Manitoba, Canada

Kraut

Walld²

2003

Scand J Work Environ Health

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Section: Discussionmentioning

confidence: 99%

Section: Identification Of Attempted and Successful Suicide Casesmentioning

confidence: 99%

Influence of lack of full-time employment on attempted suicide in Manitoba, Canada

Kraut

Walld²

2003

Scand J Work Environ Health

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“…Medium-scale single-strand RNA synthesis RNA oligonucleotides were synthesized at a scale of 1-2 mmol on an ABI 394 DNA/RNA Synthesizer or BioAutomation MerMade-12 using commercially available 59-O-DMT phosphoramidite monomers (ChemGenes, Glen Research) following standard protocols for solid-phase synthesis and deprotection (Bernstein et al 2001a;Fallows et al 2001). Bis-cyanoethyl-N,N-diisopropyl phosphoramidite was used to synthesize phosphates (ChemGenes).…”

Section: Small-scale Synthesismentioning

confidence: 99%

Comprehensive evaluation of canonical versus Dicer-substrate siRNA in vitro and in vivo

Foster

Barros²,

Duncan³

et al. 2012

RNA

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Since the discovery of RNA interference (RNAi), researchers have identified a variety of small interfering RNA (siRNA) structures that demonstrate the ability to silence gene expression through the classical RISC-mediated mechanism. One such structure, termed ''Dicer-substrate siRNA'' (dsiRNA), was proposed to have enhanced potency via RISC-mediated gene silencing, although a comprehensive comparison of canonical siRNAs and dsiRNAs remains to be described. The present study evaluates the in vitro and in vivo activities of siRNAs and dsiRNAs targeting Phosphatase and Tensin Homolog (PTEN) and Factor VII (FVII). More than 250 compounds representing both siRNA and dsiRNA structures were evaluated for silencing efficacy. Lead compounds were assessed for duration of silencing and other key parameters such as cytokine induction. We identified highly active compounds from both canonical siRNAs and 25/27 dsiRNAs. Lead compounds were comparable in potency both in vitro and in vivo as well as duration of silencing in vivo. Duplexes from both structural classes tolerated 29-OMe chemical modifications well with respect to target silencing, although some modified dsiRNAs demonstrated reduced activity. On the other hand, dsiRNAs were more immunostimulatory as compared with the shorter siRNAs, both in vitro and in vivo. Because the dsiRNA structure does not confer any appreciable benefits in vitro or in vivo while demonstrating specific liabilities, further studies are required to support their applications in RNAi therapeutics.

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“…The outer ring of studies in Figure 1 represents special files--both clinical and survey data--used for various projects (Bernstein et al 2001;Robinson et al 1997;Murray et al 2002;Mustard et al 1999). Increasingly, primary data are being collected with record linkage in mind.…”

Section: Administrative Datamentioning

confidence: 99%

Working More Productively: Tools for Administrative Data

Roos

Soodeen²,

Bond³

et al. 2003

Health Services Research

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Objective. This paper describes a web‐based resource (http://www.umanitoba.ca/centres/mchp/concept/) that contains a series of tools for working with administrative data. This work in knowledge management represents an effort to document, find, and transfer concepts and techniques, both within the local research group and to a more broadly defined user community. Concepts and associated computer programs are made as “modular” as possible to facilitate easy transfer from one project to another. Study Setting/Data Sources. Tools to work with a registry, longitudinal administrative data, and special files (survey and clinical) from the Province of Manitoba, Canada in the 1990–2003 period. Data Collection. Literature review and analyses of web site utilization were used to generate the findings. Principal Findings. The Internet‐based Concept Dictionary and SAS macros developed in Manitoba are being used in a growing number of research centers. Nearly 32,000 hits from more than 10,200 hosts in a recent month demonstrate broad interest in the Concept Dictionary. Conclusions. The tools, taken together, make up a knowledge repository and research production system that aid local work and have great potential internationally. Modular software provides considerable efficiency. The merging of documentation and researcher‐to‐researcher dissemination keeps costs manageable.

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The relationship between inflammatory bowel disease and socioeconomic variables

Cited by 122 publications

References 15 publications

Influence of lack of full-time employment on attempted suicide in Manitoba, Canada

Influence of lack of full-time employment on attempted suicide in Manitoba, Canada

Comprehensive evaluation of canonical versus Dicer-substrate siRNA in vitro and in vivo

Working More Productively: Tools for Administrative Data

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