The relationship between inflammation and mean platelet volume in varicocele pathophysiology

Demirer, Zafer; Karademir, İbrahim; Uslu, Ali Uğur; Gürağaç, Ali; Aksu, Yusuf

doi:10.1016/j.androl.2017.06.005

Cited by 17 publications

(20 citation statements)

References 29 publications

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“…Elevated MPV indicates an increase in platelet volume and an increase in the number of large‐sized platelets, which may be a vascular risk factor for triggering endothelial dysfunction in patients with varicocele, as an important indicator of platelet reactivity, MPV can provide guidance for the study of varicocele pathophysiology and the relevant vascular pathologies (Coban et al ., ). Varicocele may be induced by an inflammatory incident and lead to local and/or systemic inflammation, as reported by Demirer et al ., increased MPV levels in patients with varicocele may be associated with inflammation, and the underlying mechanism may be the result of low‐grade inflammation (Demirer et al ., ). Platelet activation plays an important role in inflammation and may be an important vascular cause of varicocele.…”

Section: Discussionmentioning

confidence: 97%

Relationship between varicocele and platelet indices: changes of mean platelet volume before and after operation

Zhang¹,

Liang

et al. 2019

Andrology

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Background: The correlation between the increased mean platelet volume and varicocele is controversial. Objectives: We designed this research to demonstrate the correlation relationship between varicocele and mean platelet volume by studying the changes of mean platelet volume in patients with varicocele before and after operation. Materials and methods: A total of 317 patients with left unilateral varicocele underwent operation, and 293 healthy adult males were enrolled in the study. We collected diagnostic data for preoperative patients through physical examination, color Doppler ultrasonography, and blood routine, and recorded the follow-up data at 6 months after operation for varicocele. Platelet indices and the degree of varicocele or the diameter of spermatic vein correlation analysis were performed. Mean platelet volume values of preoperative and 6-month postoperative were statistically evaluated. Results: We found that the degree of varicocele and the diameter of spermatic vein were positively correlated with mean platelet volume (p = 0.001 or p < 0.001). When the left unilateral varicocele patients and healthy subjects were compared, there was a significant increase in mean platelet volume (p = 0.003). Mean platelet volume values of 96 varicocele patients who were cured by operation for varicocele after 6 months were decreased significantly more than preoperative (p = 0.039), but 32 varicocele patients of 6month postoperative recurrence could not prove this change (p = 0.930). Discussion and conclusion: Our research proves that mean platelet volume was positively correlated with the degree of varicocele and the diameter of spermatic vein and varicocele patients showed significantly higher mean platelet volume than healthy subjects. The mean platelet volume of varicocele patients cured by operation for varicocele after 6 months was lower than before, but there was no difference in mean platelet volume between 6-month postoperative recurrent patients with preoperative.

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Section: Discussionmentioning

confidence: 97%

Relationship between varicocele and platelet indices: changes of mean platelet volume before and after operation

Zhang¹,

Liang

et al. 2019

Andrology

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“…On the other hand, the activation of platelets can be found in the pathophysiological changes in many biological processes, that is, infection, inflammation, and tumorigenesis. In the case of inflammation, platelets were rapidly recruited and participated in the pathogenesis of inflammation by secreting cytokines, chemokines, and other inflammatory mediators; however, the relationship between the platelet and HCA has not yet been reported. Interestingly, in our study, we observed that the platelet count of the patients was significantly increased in HCA group compared with the control group ( P < 0.001), and the platelet count in HCA group was significantly higher than in non‐HCA group ( P < 0.001); moreover, receiver operating characteristic curve has been drawn to evaluate the diagnostic value of PLT/WBC to distinguish HCA patients from non‐HCA patients.…”

Section: Discussionmentioning

confidence: 99%

Maternal peripheral blood platelet‐to‐white blood cell ratio and platelet count as potential diagnostic markers of histological chorioamnionitis‐related spontaneous preterm birth

Li-yin

Pan

Rong-lian

et al. 2019

Clinical Laboratory Analysis

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Background Histological chorioamnionitis (HCA) is one of the leading causes of spontaneous preterm birth, thus, to identify novel biomarkers for the early diagnosis of HCA is in a great need. Objective To investigate the diagnostic value of maternal peripheral blood platelet‐to‐white blood cell ratio (PLT/WBC) and platelet (PLT) counts in HCA‐related preterm birth. Methods A total of 400 patients with preterm birth were enrolled in this study: non‐HCA group (n = 193) and HCA group (n = 207), and 87 full‐term pregnancies were enrolled as the control. The peripheral blood of the participators was collected, and the neutrophil count, WBC count, platelet count, and levels of C‐reactive protein (CRP) and procalcitonin were recorded, and the platelet‐to‐white blood cell ratio (PLT/WBC) of the participators was calculated. Receiver operating characteristic (ROC) curve has been drawn to show the sensitivity and specificity of PLT/WBC and PLT count for the diagnosis of HCA‐related spontaneous preterm birth patients. Results The neutrophil count, WBC count, and procalcitonin show no significant differences among the three groups, and the PLT count, PLT/WBC, and CRP (P < 0.05) were significantly increased in HCA group compared with non‐HCA group; moreover, the area under the curve (AUC) of PLT/WBC, PLT, and CRP was 0.744 (95% confidence interval [CI], 0.6966‐0.7922), 0.8095 (95% CI, 0.7676‐0.8514), and 0.5730 (95% CI, 0.5173‐0.6287), respectively. Conclusion Platelet count and PLT/WBC may become a potential biomarker of HCA‐related spontaneous preterm birth.

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“…These markers were significantly higher in subfertile patients with varicocele compared to fertile men (Fig. 4) (Coban et al, 2015;Demirer et al, 2017;Nazari et al, 2017). It was found that spermatozoa motility is reduced in response to elevated ENA-78 in subfertile men with varicocele (Nazari et al, 2017); and the increased MPV tends to decrease following varicocelectomy (Coban et al, 2015).…”

Section: The Role Of Inflammation In the Pathophysiology Of Varicocelementioning

confidence: 92%

“…4) (Coban et al, 2015;Demirer et al, 2017;Nazari et al, 2017). The mean platelet volume (MPV), seminal epithelial neutrophil activating peptide-78 (ENA-78), and seminal IL-1b are laboratory indicators of inflammation status.…”

Section: The Role Of Inflammation In the Pathophysiology Of Varicocelementioning

confidence: 99%

A global view of the pathophysiology of varicocele

2018

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Varicocele is the most common abnormality identified in men being evaluated for subfertility. In this comprehensive review of the pathophysiology of varicocele, we will shed light on novel pathophysiological findings and their clinical implications that may direct future researches; we will shed light on the impact of transient scrotal hyperthermia and the roles of inflammation and differential protein expression and androgen expression in spermatozoa on inducing pathophysiological findings. Furthermore, we will clarify the linked processes contributing to the pathophysiology of varicocele and the impact of genetics on the induction of these processes. Spermatogenesis is a temperature-sensitive process, and heat stress of varicocele is considered the most plausible cause of impaired spermatogenesis. The three processes associated with the presence of varicocele - heat stress, excess reactive oxygen species, and increased apoptosis - appear to be linked; heat stress is associated with increased levels of reactive oxygen species and oxidative stress, which can induce apoptosis. The genetic role should not be overlooked as a contributing factor in the induction of heat stress, excess reactive oxygen species/oxidative stress, and apoptosis; this is evidenced by the association of varicocele with decreased expression of heat-shock proteins, higher polymorphism of glutathione S transferase and nitric oxide synthase genes, and increased BAX and decreased BCL2 genes and proteins. In this article, we will highlight the need of application of novel diagnostic techniques that can provide a precise pathophysiological diagnosis to guide potential specific innovative therapies. Innovative therapies can counteract the varicocele-induced stasis, suppress the degenerative effects of testicular hyperthermia, reduce the varicocele-induced apoptosis, and target the elevated-neutrophil products aiming at abrogating the testicular damage caused by the induced varicocele in rats/mice. In conclusion, on the basis of the novel scientific research, it may be possible to formulate new treatments and achieve the appropriate selection of patients who can benefit from these treatments.

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The relationship between inflammation and mean platelet volume in varicocele pathophysiology

Cited by 17 publications

References 29 publications

Relationship between varicocele and platelet indices: changes of mean platelet volume before and after operation

Relationship between varicocele and platelet indices: changes of mean platelet volume before and after operation

Maternal peripheral blood platelet‐to‐white blood cell ratio and platelet count as potential diagnostic markers of histological chorioamnionitis‐related spontaneous preterm birth

A global view of the pathophysiology of varicocele

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