The relationship between IL-6 levels and the angiographic severity of coronary artery disease following percutaneous coronary intervention in acute coronary syndrome patients

Yang, Ling; Weng, Hairong; Tang, Shengxing

doi:10.1186/s12872-021-02406-7

Cited by 11 publications

(9 citation statements)

References 39 publications

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“…A systematic review and meta-analysis of studies investigated the association of CRP, IL-6 and fibrinogen with the risk of recurrent stroke, and these three factors were found to be closely linked to the extent of coronary artery disease in ACS patients. Recently, higher circulating IL-6 levels in community-dwelling individuals have been shown to be linearly associated with a higher long-term risk of incident ischemic stroke, and independent of conventional vascular risk factors, they have been reported in several other studies (9,45,46). These reports and our results demonstrate that IL-6 is an atherothrombosis-associated inflammatory response cytokine.…”

Section: Discussionsupporting

confidence: 86%

Soluble programmed cell death-ligand 1 as a new potential biomarker associated with acute coronary syndrome

Yi²,

Wei³

et al. 2022

Front. Cardiovasc. Med.

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BackgroundSoluble programmed cell death-ligand 1 (sPD-L1) has been well documented to activate immunosuppression and is considered an essential predictor of negative clinical outcomes for several malignances and inflammatory conditions. However, the clinical significance of sPD-L1 in the peripheral blood of patients with coronary artery disease (CAD) remains unclear. The aim of this study was to assess the correlations of sPD-L1 with clinical features in CAD patients and evaluate the diagnostic value of this protein in CAD.MethodsA total of 111 CAD patients and 97 healthy volunteers who served as healthy controls (HCs) were consecutively enrolled. Plasma levels of sPD-L1 were measured with an amplified enzyme-linked immunosorbent assay (ELISA), and hs-CRP was measured with a C-reactive protein assay kit. The levels of other inflammatory cytokines were assessed in 88 CAD patients and 47 HCs by a multiparameter immunoluminescence flow cytometry detection technique. A logistic regression model was used to assess the independent association of sPD-L1 with acute coronary syndrome (ACS). The correlation between sPD-L1 and inflammatory cytokines in ACS was also assessed.ResultsPlasma levels of sPD-L1 were significantly increased in CAD patients, especially those with ACS. Univariate logistic regression analysis revealed that sPD-L1 (OR: 3.382, 95% CI: 2.249–5.084, p < 0.001), BMI, hypertension, diabetes, dyslipidemia, previous MI, and the levels of HDL-C, LDL-C and hs-CRP were significantly associated with ACS. sPD-L1 (OR: 3.336, 95% CI: 1.084–6.167, p = 0.001) was found to be independently and significantly associated with ACS in the subsequent multivariable logistic regression analysis. Additionally, elevated plasma sPD-L1 levels were associated with increased interleukin-6 and interleukin-8 levels in ACS patients. Receiver operating characteristic (ROC) analysis showed that the AUC of sPD-L1 for diagnosing ACS was 0.778, with a sensitivity of 73.9% and a specificity of 73.4%, which was comparable with that of the inflammatory biomarker hs-CRP.ConclusionThe plasma sPD-L1 level reflects the severity of CAD, is associated with inflammatory responses and is a potential new biomarker for the diagnosis of ACS.

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Section: Discussionsupporting

confidence: 86%

Soluble programmed cell death-ligand 1 as a new potential biomarker associated with acute coronary syndrome

Yi²,

Wei³

et al. 2022

Front. Cardiovasc. Med.

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“…Tanindi et al [14] had found that IL-6 was associated with more extensive and severe CAD as represented by GS. Despite signi cant association between high levels of IL-6 in single-and multi vessel disease groups as compared with controls, Mokhtar ER et al [15] ndings did not show signi cant association between IL-6 and GS. Gotsman I et al [16] reported that there was signi cant correlations between interleukin-6 with the severity of CAD assessed by the number of obstructed coronary vessels and the lesions severity.…”

Section: Discussionmentioning

confidence: 82%

Relationship between serum interleukin-6 levels and severity of coronary artery disease undergoing percutaneous coronary intervention

Bouzidi

Gamra

2023

Preprint

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Background: Cytokines play a potential role in atherosclerosis pathogenesis and progression. We investigated the association of interleukin-6 (IL-6) with the angiographic severity of coronary artery disease (CAD). Methods: 310 angiografically diagnosed CAD patients and 210 controls were enrolled in this study. CAD patients were stratified according to IL-6 cut-off value into high levels IL-6 group (≥ 9.5 pg/mL) and low levels IL-6 group (< 9.5 pg/mL). The severity of CAD was assessed according to Gensini score (GS), artery stenosis degree and the number of vessels involved. The mean age was 60.3 ± 11.0 years. Results:The level of IL-6 in patients was increased compared to controls and ranged from 1.5 to 3640.0 pg/mL. High levels of IL-6 were significantly associated with high levels of GS (>40) but not with stenosis degree and vessel score. GS levels were significantly more elevated in patients with high levels of IL-6 group than in low IL6 levels patients (60.6 ± 39.5 vs 46.7 ± 37.2; p = 0.027). The analysis of the ROC curve performed in myocardial infarction patients showed that IL-6 (AUC: 0.941 (CI 95% 0.886, 0.997; p<0.001) could be a powerful predictor marker in evaluating the infarct size after myocardial infarction when compared to myonecrosis biomarkers. Conclusions: IL-6 levels were associated with the severity of CAD assessed by the GS. Based on the highest levels of IL-6 measured in patients with STEMI, our study strongly suggests that IL-6 could be a powerful marker in evaluating the myocardial necrosis. ClinicalTrials.gov Number: NCT03075566 (09/03/2017)

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“…Tanindi et al [ 13 ] had found that IL-6 was associated with more extensive and severe CAD as represented by GS. Despite significant association between high levels of IL-6 in single- and multi vessel disease groups as compared with controls, Mokhtar ER et al [ 14 ] findings did not show significant association between IL-6 and GS. Gotsman I et al [ 15 ] reported that there was significant correlations between interleukin-6 with the severity of CAD assessed by the number of obstructed coronary vessels and the lesions severity.…”

Section: Discussionmentioning

confidence: 93%

Relationship between serum interleukin-6 levels and severity of coronary artery disease undergoing percutaneous coronary intervention

Bouzidi,

Gamra

2023

BMC Cardiovasc Disord

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Background Cytokines play a potential role in atherosclerosis pathogenesis and progression. We investigated the association of interleukin-6 (IL-6) with the angiographic severity of coronary artery disease (CAD). Methods Three hundred ten angiografically diagnosed CAD patients and 210 controls were enrolled in this study. CAD patients were stratified according to IL-6 cut-off value into high levels IL-6 group (≥ 9.5 pg/mL) and low levels IL-6 group (< 9.5 pg/mL). The severity of CAD was assessed according to Gensini score (GS), artery stenosis degree and the number of vessels involved. The mean age was 60.3 ± 11.0 years. Results The level of IL-6 in patients was increased compared to controls and ranged from 1.5 to 3640.0 pg/mL. High levels of IL-6 were significantly associated with high levels of GS (> 40) but not with stenosis degree and vessel score. GS levels were significantly more elevated in patients with high levels of IL-6 group than in low IL6 levels patients (60.6 ± 39.5 vs 46.7 ± 37.2; p = 0.027). The analysis of the ROC curve performed in myocardial infarction patients showed that IL-6 (AUC: 0.941 (CI 95% 0.886, 0.997; p < 0.001) could be a powerful predictor marker in evaluating the infarct size after myocardial infarction when compared to myonecrosis biomarkers. Conclusions IL-6 levels were associated with the severity of CAD assessed by the GS. Based on the highest levels of IL-6 measured in patients with STEMI, our study strongly suggests that IL-6 could be a powerful marker in evaluating the myocardial necrosis. Trial registration ClinicalTrials.gov Number: NCT03075566 (09/03/2017).

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The relationship between IL-6 levels and the angiographic severity of coronary artery disease following percutaneous coronary intervention in acute coronary syndrome patients

Cited by 11 publications

References 39 publications

Soluble programmed cell death-ligand 1 as a new potential biomarker associated with acute coronary syndrome

Soluble programmed cell death-ligand 1 as a new potential biomarker associated with acute coronary syndrome

Relationship between serum interleukin-6 levels and severity of coronary artery disease undergoing percutaneous coronary intervention

Relationship between serum interleukin-6 levels and severity of coronary artery disease undergoing percutaneous coronary intervention

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