The Relationship between Hypomagnesemia and Pulmonary Function Tests in Patients with Chronic Asthma

Kılıç, Hatice; Kanbay, Asiye; Karalezli, Ayşegül; Babaoğlu, Elif; Hasanoğlu, H. Canan; Erel, Özcan; Ateş, Can

doi:10.1159/000487760

Cited by 10 publications

(7 citation statements)

References 26 publications

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“…The role of magnesium in asthma is not clear, although many studies have found hypomagnesemia in chronic stable asthmatics as well as during asthma exacerbations [32,33,34].…”

Section: Cardiovascular Manifestationsmentioning

confidence: 99%

Magnesium: The Forgotten Electrolyte—A Review on Hypomagnesemia

2019

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Magnesium is the fourth most abundant cation in the body and the second most abundant intracellular cation. It plays an important role in different organ systems at the cellular and enzymatic levels. Despite its importance, it still has not received the needed attention either in the medical literature or in clinical practice in comparison to other electrolytes like sodium, potassium, and calcium. Hypomagnesemia can lead to many clinical manifestations with some being life-threatening. The reported incidence is less likely than expected in the general population. We present a comprehensive review of different aspects of magnesium physiology and hypomagnesemia which can help clinicians in understanding, identifying, and treating this disorder.

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“…The role of magnesium in asthma is not clear, although many studies have found hypomagnesemia in chronic stable asthmatics as well as during asthma exacerbations [32,33,34].…”

Section: Cardiovascular Manifestationsmentioning

confidence: 99%

Magnesium: The Forgotten Electrolyte—A Review on Hypomagnesemia

2019

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“…5 In a study done by Fantidis P et al which measured polymorphonuclear magnesium content in patients with asthma, low polymorphonuclear magnesium content was seen in patients with bronchial asthma. 6 In a study by Kilic et al 7 and OS Alamoudi 8 , hypomagnesemia and hypophosphatemia were found to be the most common electrolyte abnormalities in patients with chronic stable asthma. There is no popular marker for association with level of control of asthma.…”

Section: Discussionmentioning

confidence: 96%

“…Anxiety and Depression among Adolescents control. It was serum magnesium, 2,3 erythrocytic magnesium, 4,5 polymorphonuclear magnesium, 6 hypomagnesemia and hypophosphatemia 7,8 in different studies.…”

Section: Original Articlementioning

confidence: 91%

“…Search is on to find markers of bronchial asthma control in the form of serum magnesium, 2,3 erythrocytic magnesium, 4,5 polymorphonuclear magnesium, 6 hypomagnesemia and hypophosphatemia. 7,8 But none has become popular. As magnesium and calcium are antagonistic to each other and magnesium has beneficial bronchodilating effect and reduces bronchial hyperreactivity 15 while calcium causes contraction, the ratio of magnesium and calcium can have an association between level of asthma control.…”

Section: Original Articlementioning

confidence: 99%

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Association between Serum Magnesium to Calcium Ratio with Level of Asthma Control in Children

Kundu

Dutta

Chatterjee

et al. 2022

J. Nepal Paedtr. Soc.

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Introduction: Bronchial asthma is an inflammatory reversible obstructive airway disease. This study aims to determine the association between serum magnesium to calcium ratio with level of asthma control in children by comparing serum magnesium to calcium ratio between - children with well controlled, partly controlled and uncontrolled asthma. Methods: An analytical cross sectional study was done on 90 children diagnosed with bronchial asthma between five to 12 years age from January 2019 to June 2020. Children were selected from the outpatient and inpatient departments of paediatric medicine of a tertiary care medical college hospital. They were classified into well controlled, partly controlled and uncontrolled groups as per Global Initiative for Asthma (GINA) assessment of asthma control in children. The serum magnesium to serum calcium ratio of these children were compared between the groups classified. Results: Mean level of serum magnesium to calcium ratio in well controlled group was 0.29857 (SD 0.07633), partly controlled 0.2439 (SD 0.0532), uncontrolled 0.2545 (SD 0.04467), respectively. Serum magnesium to calcium ratio more than or equal to 0.3 was positively correlated with well controlled asthma. Comparisons of serum magnesium to calcium ratio of well controlled group with partly controlled, uncontrolled and both partly and uncontrolled were statistically significant. Conclusions: Higher serum magnesium to calcium ratio is associated with well controlled asthma. In our study, serum magnesium to calcium ratio more than 0.3 is significantly associated with well controlled asthma.

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“…This may be related to respiratory muscle weakness caused by hypomagnesemia (10) . In addition, magnesium regulates the contractibility of smooth muscle cells, and hypomagnesemia leads to bronchospasm, which in turn prolongs mechanical ventilation (11) . Our study found that the duration of vasoactive drug use in patients with hypomagnesemia was longer than that in patients without hypomagnesemia, however, the pathological mechanism remained unclear.…”

Section: Discussionmentioning

confidence: 99%

Effect of Hypomagnesemia On The Prognosis of Patients With Sepsis in ICU: A Retrospective Cohort Study

et al. 2021

Preprint

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Objective Existing studies have shown that the incidence of hypomagnesemia may be as high as 60%. However, the correlation between hypomagnesia and sepsis mortality remains elusive. The current study evaluated the effect of hypomagnesemia on the prognosis of patients with sepsis in ICU. Methods It was a retrospective cohort study based on an online database named MIMIC III. A total of 1448 sepsis patients with serum magnesium were admitted to the database, among which 645 patients were screened out. Results At 28 days, 99 patients (30.84%) in the hypomagnesemia group and 123 patients (38.0%) (P = 0.06) in the non-hypomagnesemia group died. There was no correlation between hypomagnesemia and 28-day mortality in patients with sepsis (HR = 1.07; P = 0.87, 95% CI). However, the duration of mechanical ventilation (P < 0.01), the duration of vasoactive drug use (P < 0.01), the length of ICU stay (P < 0.01), and the length of hospital stay (P < 0.01) of patients in the hypomagnesemia group were higher than those in the non-hypomagnesemia group. In the subgroup analysis, the time of no vasopressor (P < 0.01) and the time of no mechanical ventilation (P < 0.01) in the magnesium supplementation group were significantly longer than those in the non-magnesium supplementation group. More importantly, the 14-day mortality (30.8% vs 48.9%, P < 0.01) and 28-day mortality (33.8% vs 48.9%, P = 0.03) in patients with magnesium supplementation were lower than patients without magnesium supplementation. Conclusions For sepsis patients in ICU, although hypomagnesemia had no significant correlation with 28-day mortality, it still prolonged the duration of mechanical ventilation and vasoactive drug use, and increased the length of ICU stay and hospital stay. Even for patients with normal serum magnesium levels, optimizing serum magnesium levels may improve the prognosis of patients with sepsis.

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The Relationship between Hypomagnesemia and Pulmonary Function Tests in Patients with Chronic Asthma

Cited by 10 publications

References 26 publications

Magnesium: The Forgotten Electrolyte—A Review on Hypomagnesemia

Magnesium: The Forgotten Electrolyte—A Review on Hypomagnesemia

Association between Serum Magnesium to Calcium Ratio with Level of Asthma Control in Children

Effect of Hypomagnesemia On The Prognosis of Patients With Sepsis in ICU: A Retrospective Cohort Study

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