The Relationship between Human Serum Cholinesterase and Serum Albumin

Levine, Milton Gjelhaug; Hoyt, Robert

doi:10.1126/science.111.2881.286

Cited by 22 publications

(7 citation statements)

References 6 publications

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“…Kunkel and Ward (9) have already drawn attention to the close relation between the low plasma albumin and low plasma cholinesterase values in chronic liver disease, and we have confirmed this by serial estimations carried out on several of our patients over periods of 12 months or more. We have failed to observe any such marked relation, however, in acute liver disease, and we consider that the conclusions of Levine and Hoyt (25) do not merit the assumption that if the serum albumin' level is low, the serum cholinesterase level must also be low. Our results taken in conjunction with those of Kunkel and Ward (9) and Alcalde (11) justify the conclusion that chronic liver disease is almost invariably associated with low plasma cholinesterase activity.…”

Section: Discussionmentioning

confidence: 89%

Plasma Cholinesterase Activity in Liver Disease: Its Value as a Diagnostic Test of Liver Function Compared With Flocculation Tests and Plasma Protein Determinations 1

Wilson¹,

Calvert²,

Geoghegan³

1952

J. Clin. Invest.

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The physiological significance of plasma cholinesterase is not clearly understood, but attention has recently been focussed on its relation to protein metabolism. It has been identified in high concentration in the a2 globulin of Cohn's fraction IV-6-3 (1).The evidence which has accumulated suggests that the liver is the probable source of plasma cholinesterase; and low values of plasma cholinesterase activity have been reported in patients with liver disease (2-1 1). We have been investigating. acetylcholine and water metabolism in liver disease, and the present communication is an account of work undertaken to determine in which types of liver and biliary tract disease the plasma cholinesterase activity is deranged, and what diagnostic significance can be attached to these findings. Concurrent determinations of plasma proteins and flocculation tests were also made. MATERIAL AND METHODSThe observations were carried out on 43 patients with liver and biliary tract disease. Of these, 15 patients were suffering from acute, four from sub-acute, 14 from chronic liver disease, and ten from extra-hepatic biliary obstruction. The plasma cholinesterase activity of 144 normalsubjects was also studied; of these, 100 were healthy blood donors, and 44 were convalescent patients in hospital, who had no history or clinical evidence of liver disease; concurrent protein estimations were also made on the plasma of the latter patients.Specimens of venous blood were transferred immediately after collection to heparinized tubes and centrifuged. After separation of the plasma, the red cells were washed twice with normal saline, and then laked with an amount of distilled water equal to the original volume of the 1 The expenses of this work were defrayed partially by a grant from the Medical Research Council, from whom one of us (R. J. C.) is in receipt of a whole-time grant, and by financial assistance from the Ministry of Supply, from whom one of us (H. G.) receives a wholetime grant. Maizels (14).In assessing the value of plasma cholinesterase activity as a diagnostic test of liver and biliary tract disease a comparison has been made with the results obtained for plasma albumin and globulin and the serum flocculation tests. For the interpretation of the flocculation tests we have adopted as an index of abnormality the conventional standards used in this hospital (14), for the colloidal red and cephalin cholesterol tests, flocculation greater than one plus (+) at 24 hours, and for the thymol turbidity test a value greater than 4 units. RESULTSIt will be convenient to begin by comparing the total results of the 33 patients with liver disease with those of the normal subjects in respect of plasma cholinesterase activity, plasma albumin and globulin estimations. Our aim here is to determine the limits of normality for these tests. The results have been plotted and give the overlapping histograms seen in Figure 1. The best discrimination will be given by the point on the scale where the two distributions (A) normal and (B) diseased inte...

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Section: Discussionmentioning

confidence: 89%

Plasma Cholinesterase Activity in Liver Disease: Its Value as a Diagnostic Test of Liver Function Compared With Flocculation Tests and Plasma Protein Determinations 1

Wilson¹,

Calvert²,

Geoghegan³

1952

J. Clin. Invest.

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“…Multivariate analyses revealed that BMI, GPT, serum albumin or total cholesterol were strongly correlated with CHE irrespective of OR gene nSNPs ( P < 0.0001; Table 3). These correlation results have been previously reported 30–32 …”

Section: Discussionmentioning

confidence: 99%

“…These correlation results have been previously reported. [30][31][32] Serum albumin levels also reflect protein synthesis in the liver. However, Zou et al suggested that serum cholinesterase activity could be a better and more sensitive parameter than albumin for reflecting aberrant protein synthesis and damage to the liver.…”

Section: E Vidence For the Presence In The Human Genomementioning

confidence: 99%

Common null variant, Arg192Stop, in a G‐protein coupled receptor, olfactory receptor 1B1, associated with decreased serum cholinesterase activity

Koyano

Emi

Saito

et al. 2008

Hepatology Research

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“…Wescoe, Hunt, Riker, and Litt gave 2 mg. di-isopropylfluorophosphate to normal subjects and patients with liver disease and found that the rate of regeneration of the enzyme was depressed in the latter group (24). A third bit of evidence has been the correlation of serum albumin with serum cholinesterase in liver disease and other disease states (13,14,18,25 (17) (Table II). It is still possible that the return to normal of serum cholinesterase may best indicate the earliest point in the recovery from hepatic injury, at which the patient may be allowed full activity.…”

Section: Resultsmentioning

confidence: 99%

“…Low levels are found in extra-hepatic obstruction due to malignancy, possibly due to malnutrition or impairment of liver function by metastases (14,25,26 …”

Section: Resultsmentioning

confidence: 99%

Colorimetric Determination of Serum Cholinesterase: Its Value in Hepatic and Biliary Tract Diseases 1

Sleisenger¹,

Almy²,

Gilder³

et al. 1953

J. Clin. Invest.

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The Relationship between Human Serum Cholinesterase and Serum Albumin

Cited by 22 publications

References 6 publications

Plasma Cholinesterase Activity in Liver Disease: Its Value as a Diagnostic Test of Liver Function Compared With Flocculation Tests and Plasma Protein Determinations 1

Plasma Cholinesterase Activity in Liver Disease: Its Value as a Diagnostic Test of Liver Function Compared With Flocculation Tests and Plasma Protein Determinations 1

Common null variant, Arg192Stop, in a G‐protein coupled receptor, olfactory receptor 1B1, associated with decreased serum cholinesterase activity

Colorimetric Determination of Serum Cholinesterase: Its Value in Hepatic and Biliary Tract Diseases 1

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