The relationship between human papillomavirus and lower genital intraepithelial neoplasia in immunosuppressed women

Sillman, Frederick H.; Stanek, Albert; Sedlis, Alexander; Rosenthal, Julian; Lanks, Karl W.; Buchhagen, Dorothy L.; Nicastri, Anthony D.; Boyce, John

doi:10.1016/s0002-9378(84)90369-7

Cited by 122 publications

(30 citation statements)

References 7 publications

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“…This possibly explains the differences in RR magnitudes between these two studies. Novel findings in our study include the substantial excess risk for cancer of the tongue, anus, vulva and vagina, but no convincing excess risk for in situ or invasive cancer of the cervix as reported previously (Porreco et al, 1975;Sillman et al, 1984), and evidence of a higher risk for kidney cancer with pelvic origin than that of parenchymal origin.…”

Section: Discussionsupporting

confidence: 50%

Cancer risk following organ transplantation: a nationwide cohort study in Sweden

et al. 2003

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A substantial excess risk of lymphomas and nonmelanoma skin cancer has been demonstrated following organ transplantation. Large sample size and long follow-up time may, however, allow more accurate risk estimates and detailed understanding of long-term cancer risk. The objective of the study was to assess the risk of cancer following organ transplantation. A nationwide cohort study comprising 5931 patients who underwent transplantation of kidney, liver or other organs during 1970 -1997 in Sweden was conducted. Complete follow-up was accomplished through linkage to nationwide databases. We used comparisons with the entire Swedish population to calculate standardised incidence ratios (SIRs), and Poisson regression for multivariate internal analyses of relative risks (RRs) with 95% confidence intervals (CI). Overall, we observed 692 incident first cancers vs 171 expected (SIR 4.0; 95% CI 3.7 -4.4). We confirmed marked excesses of nonmelanoma skin cancer (SIR 56.2; 95% CI 49.8 -63.2), lip cancer (SIR 53.3; 95% CI 38.0 -72.5) and of non-Hodgkin's lymphoma (NHL) (SIR 6.0; 95% CI 4.4 -8.0). Compared with patients who underwent kidney transplantation, those who received other organs were at substantially higher risk of NHL (RR 8.4; 95% CI 4.3 -16). Besides, we found, significantly, about 20-fold excess risk of cancer of the vulva and vagina, 10-fold of anal cancer, and five-fold of oral cavity and kidney cancer, as well as two-to four-fold excesses of cancer in the oesophagus, stomach, large bowel, urinary bladder, lung and thyroid gland. In conclusion, organ transplantation entails a persistent, about four-fold increased overall cancer risk. The complex pattern of excess risk at many sites challenges current understanding of oncogenic infections that might become activated by immunologic alterations.

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Section: Discussionsupporting

confidence: 50%

Cancer risk following organ transplantation: a nationwide cohort study in Sweden

et al. 2003

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“…We also looked for evidence of cervical human papillomavirus (HPV) infection in these patients, in view of the continuing debate concerning the role of this virus in cervical malignancy (Anonymous, 1985a). There is some evidence that immunosuppression may lead to the malignant conversion of papillomavirus induced lesions in animals (Campo & Jarrett, 1987) and in man (Sillman et al, 1984;Rudlinger et al, 1986;Schneider et al, 1983 Table IV shows that the lymphoma patients with cervical koilocytosis without CIN were older, more likely to be parous and became sexually active rather later than the patients in whom no significant abnormality was detected. They also had had their lymphomas diagnosed for longer periods.…”

mentioning

confidence: 98%

“…Although cervical neoplasia is reported to be increased in incidence in other immunosuppressed patients such as renal transplant recipients (Porreco et al, 1975), the co-existence of this disease with lymphomas has previously been described only in the form of isolated case reports (ShokriTabibzadeh et al, 1981;Sillman et al, 1984).…”

mentioning

confidence: 99%

Cervical intraepithelial neoplasia in lymphoma patients: a cytological and colposcopic study

Hughes¹,

Colquhoun²,

Eccles³

et al. 1989

Br J Cancer

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“…Another study showed HPV infection in all immunosuppressed women presenting with neoplasia of lower genital tract. 22 In the 1990s, as the diagnosis of HPV infection by molecular diagnosis was developed, there were many reports confirming the rise in the incidence of infection with HPV 23 and other comorbidities, which included warts 24 and cervical squamous intraepithelial lesions 25 in patients who were immunosuppressed. The association of reduced cell-mediated immunity and consequent increase in HPV infection and associated disease in HIV-infected individuals has been demonstrated in various studies wherein these patients have shown increased prevalence [26][27][28][29][30][31] and longer period of persistence of HPV infection, 26,[32][33][34][35] which also provides a strong evidence to support the role of cell-mediated immunity.…”

Section: Discussionmentioning

confidence: 99%

Immune Response Profiling of Patients with Anogenital Warts

Singh¹,

Thakral²,

Kar³

et al. 2017

Indian Journal of Medical Biochemistry

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The incidence of anogenital warts, commonly caused by human papillomavirus (HPV-6 and HPV-11), is increasing worldwide. These infections are frequently associated with relapse, possibly due to weak host immunity. However, the role of cell-mediated immune players in combating infection is not clearly understood till date. Here, we attempted to understand the immune profile among patients with anogenital warts. In this study, we compared the T-helper cell (Th1 and Th2) response in patients with venereal warts due to HPV-6 and HPV-11 infection relative to healthy controls (HCs) in vitro. In the in vitro model, the peripheral blood mononuclear cells were stimulated with HPV peptide 6 or 11, stained for T-cell surface marker and intracellular cytokines (interferon [IFN]-□ and interleukin [IL]-4), and were analyzed by flow cytometry. In the present study, significant decrease was observed in the frequency of IFN-□ T cells as compared with HCs. On the contrary, frequency of T cells expressing IL-4 was significantly increased in the patients. The observed functional skewing of HPV-specific T cells from Th1 to Th2 response in patients indicated suppressed immunity against the HPVs. Findings of our study have potential in the near future for strategizing adjunct immunomodulation approaches with the standard treatment for early remission and prevention of recurrence. How to cite this article Singh M, Thakral D, Kar HK, Rishi N, Mitra DK. Immune Response Profiling of Patients with Anogenital Warts. Indian J Med Biochem 2017;21(1):11-16.

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The relationship between human papillomavirus and lower genital intraepithelial neoplasia in immunosuppressed women

Cited by 122 publications

References 7 publications

Cancer risk following organ transplantation: a nationwide cohort study in Sweden

Cancer risk following organ transplantation: a nationwide cohort study in Sweden

Cervical intraepithelial neoplasia in lymphoma patients: a cytological and colposcopic study

Immune Response Profiling of Patients with Anogenital Warts

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