The relationship between human papillomavirus infection and cervical intraepithelial neoplasia in Turkish women

Abstract

To compare the prevalence of cervical human papillomavirus (HPV) infection in Turkish women with normal Papanicolaou (Pap) smear and cervical intraepithelial neoplasia (CIN). In between March 2002 and November 2005, the study was designed as case-control study. Cytologic abnormalities in Pap smears were classified according to the Bethesda System (2001). Identification of the presence of HPV was carried out by the Hybrid Capture II test for all patients. To compare the groups, Chi-square test was used. A total of 1353 reproductive aged women were screened. Of them, 1344 (99.3%) had normal or class I Pap smear. Remaining nine cases (0.7%) had CIN at several degrees (five CIN I, three CIN II, and one carcinoma in situ). While all these nine cases with cervical pathologies had HPV, only 20 cases from the other group (1.5%) had HPV (chi(2) 466.1; P = 0.0001). This is the first study of the evaluation of the association between HPV and preinvasive cervical lesions in Turkish population. In spite of low general frequency (2.1%) of cervical HPV colonization in this population, a strong correlation was found between HPV and CIN.

The Prevalence of Human Papilloma Virus Infection Among Women who Admitted to Çukurova University Faculty of Medicine Hospital

“…18 İnal ve ark. 19 İzmir' de 2002-2005 yıl la rın da, ser vi kal in tra e pi tel yal lez yon ile HPV iliş ki si nin araş tı rıl dı ğı 1353 ka dın da HC II tes ti kul la nı la rak yap tık la rı ça lış ma da, HPV DNA po zi tif li ği ni % 2.14 (29/1353) ora nın da sap ta mış tır. Po zi tif bu lu nan 19 ör ne ğin %24.1'in de (7/29) HPV 6, %27.5 (8/29)'in de HPV 11, %27.5 (8/29)'in de HPV 16, %10.3'ün de (3/29) HPV 18 ve %10.3'ün -de (3/29) HPV 31 tes pit et miş tir.…”

“…Po zi tif bu lu nan 19 ör ne ğin %24.1'in de (7/29) HPV 6, %27.5 (8/29)'in de HPV 11, %27.5 (8/29)'in de HPV 16, %10.3'ün de (3/29) HPV 18 ve %10.3'ün -de (3/29) HPV 31 tes pit et miş tir. 19 Öz türk ve ark. 20 De niz li' de 2004 yı lın da ji ne ko lo ji po lik li ni ği ne baş-vu ran 18-62 yaş ara sı 206 ka dın da HC II tes ti ile yap tık la rı ça lış ma da HPV DNA pre va lan sı nı %4.9, nor mal ser vi kal si to lo ji si olan lar da %2.1 bul muş tur.…”

“…Di ğer HPV tip le ri nin ora nı ise HPV11 için %4.4, HPV45 %4.4, HPV90 %4.4, HPV35 %2.2, HPV67 %2.2 ve HPV81 için ise %2.2 olup, mul tiple HPV en fek si yo nu %8.9 ora nın da dır. 21 Ça lış ma mız da ki ka dın lar da HPV DNA pre valan sı %5.2 (24/460) olup, ül ke miz de ya pı lan ça lış -ma lar da HPV DNA pre va lan sı De niz li' de %4.9'luk oran la bi zim bul gu mu za ben zer iken, 20 İzmir' de %2.14'lük oran la bi zim bul gu muz dan dü şük, 19 buna kar şı lık An ka ra' da ya pı lan iki ça lış ma da Ro ta ve ark.nın 18 bul gu su %11 ile Dur sun ve ark.nın 21 bulgu su %20 oran la rı bi zim bul gu muz dan yük sek tir. Yi ne ça lış ma mız da tek ve/ve ya mul tip le enfeksiyon şek lin de HR HPV enfeksiyon pre va lan sı ise %3 (14/460) olup Dur sun ve ark.nın 21 mul tip le HPV enfeksiyon bul gu su olan %8.9'dan dü şük tür.…”

Knowledge Level of Working and Student Nurses on Cervical Cancer and Human Papilloma Virus Vaccines

“…The reason of lower HPV vaccination rates can be explained by the fact that quadrivalent vaccine was approved in 2007 and bivalent vaccine was approved in 2008 by Health of Ministry (Arvas, 2007;Samer, 2009) and it has been used for five years. Besides, prevalence of HPV was reported to be low as 2-4% in our country (Arvas, 2007;Inal et al, 2007); therefore, this can be interpreted by lack of attention to HPV and cervical cancer. However; in another literature, it was reported that cervical cancer was ranked ninth among common cancers seen in women in our country (Dursun et al, 2009).…”

Awareness of Turkish Female Adolescents and Young Women about HPV and their Attitudes Towards HPV Vaccination

“…of HPV infection in Turkey is not well studied; though hospital based studies report the prevalence of HPV infection ranging from 2.1-16.5% among low-risk Turkish women (Inal et al, 2007;Eren et al, 2010).…”