The relationship between histopathology and age factor in patients who were operated for renal masses

Abstract

Objective: Renal neoplasms have a predilection to occur in older patients and they are often malignant. They may have different structural characteristics according to age groups. In our study, we have investigated age-related demographic characteristics of the patients who were operated because of suspected malignant renal masses. Material and methods:Between 2010 and 2014, 129 patients were treated surgically for suspected malignant renal masses at our institution. These cases had undergone open radical, open partial, and laparoscopic radical nephrectomies. Patients were divided into two groups based on their ages and evaluated accordingly as Group 1 (≤50 years) and Group 2 (>50 years). Groups were compared based on their clinical and pathological features.Results: Group 1 and Group 2 consisted of 29 (22.4%) and 91 (77.6%) patients, respectively. The mean age of younger patients was 43.1 years (23-49 years), with a male to female ratio of 19/10, while the average tumor size was 57.6 mm (20-120 mm). Twenty-four patients (83%) had a malignant pathology and five patients (17%) had a benign pathology. Clear cell carcinoma was diagnosed in 67% of the patients in both groups. There was no significant difference with respect to age and tumor size of male and female patients in the younger age group, while younger female adults tended to have a more benign pathology than their male counterparts (40% and 5%, respectively, p<0.05). Conclusion:There was no significant difference with respect to gender, tumor size, laterality, and surgical and pathologic features between younger and older patients. An organ-sparing approach should be strongly considered when treatment for renal tumors in young females is performed because of a potentially higher incidence of a benign pathology of renal masses.

Clinicopathological Features and Survival Data of Localized Renal Masses in Young Adults

“…Similarly, Eggener et al, (2004) reported benign pathology in 36% of young females and 9.5% in males. It is suggested that nephron sparing surgery should be preferred to young women because of these high benign mass rate (Yıkılmaz et al, 2015;Eggener et al, 2004). In our study, benign pathologies were detected in 35% of the young women and in 13,6% of the young males and this difference was statistically significant (p<0,05).…”

“…Studies in relation to gender and histopathology have reported that benign pathologies are seen at high rates in young females. Yıkılmaz et al, (2015) reported that 40% of young females had benign pathologies, while in males this rate was reported as 4% (p <0.05). Similarly, Eggener et al, (2004) reported benign pathology in 36% of young females and 9.5% in males.…”

“…The studies mentioned are related to general populations. In the young adult patient population, the proportion of bening pathologies was reported by Mohsin et al, (2012) as 11%, Yıkılmaz et al, (2015) as 16%, Eggener et al, (2004) as 20.2%. In these studies, benign pathologies such as angiomyolipoma, oncocytoma, simple cyst, hidatic cyst, pyelonephritis and schwannoma were determined at different rates.…”

Survival Outcomes in Elderly Patients with Renal Cell Carcinoma: A Single-Center Experience

“…2 In a study from Turkey, Yıkılmaz et al divided the patients into two groups according to age as follows ≤50 years and >50 years. 16 They reported that there was no significant difference regarding to gender, tumor size, laterality, surgical and pathologic features between two groups. 16 The TNM stage is a broadly utilized prognostic factor for cancer survival.…”

“…16 They reported that there was no significant difference regarding to gender, tumor size, laterality, surgical and pathologic features between two groups. 16 The TNM stage is a broadly utilized prognostic factor for cancer survival. 17 Şimşek et al reported that radiological lymph node involvement and stage were independent predictors that affecting the survival rates of renal cell carsinoma patients.…”