The Relationship Between High‐Sensitivity C‐Reactive Protein Levels and Left Ventricular Hypertrophy in Patients With Newly Diagnosed Hypertension

Abstract

The authors aimed to evaluate the relationship between high-sensitivity C-reactive protein (hs-CRP) and presence of left ventricular hypertrophy and diastolic dysfunction in patients with hypertension. A total of 95 newly diagnosed hypertensive patients (mean age, 54AE10 years) and 20 controls were included in this study. Patients were divided into four groups according to relative wall thickness as normal, concentric remodeling, concentric, and eccentric hypertrophy. hs-CRP was measured in all patients and serum hs-CRP level was shown to be increased in patients with hypertension compared with controls (0.57 mg/dL vs 0.25 mg/dL, respectively; P<.001). The hs-CRP level was highest in patients with concentric hypertrophy. When compared with controls, serum hs-CRP level was significantly higher in patients with concentric remodeling (0.61AE0.3 mg/dL vs 0.43AE0.5 mg/dL, P<.030) and concentric hypertrophy (0.69AE0.3 mg/dL vs 0.43AE0.5 mg/dL, P<.032). The present study shows that serum hs-CRP is significantly associated with left ventricular diastolic function and concentric hypertrophy in patients with hypertension. J Clin Hypertens (Greenwich). 2016;18:679-684. ª 2015 Wiley Periodicals, Inc.Systemic hypertension is an independent risk factor for cardiovascular mortality and morbidity and is associated with injury or dysfunction of different systems known as hypertensive target organ damage. Left ventricular (LV) hypertrophy (LVH) is a hypertensive target organ damage and is strongly predictive of future cardiovascular morbidity and mortality.1 Thus, assessment of LV mass (LVM) by echocardiography is a well-established procedure to estimate the risk of cardiovascular diseases in hypertensive patients. However, the pathophysiologic mechanisms underlying the progression from LVH to cardiovascular event development are still unclear, but they may include accelerated atherosclerosis caused by systemic inflammation and endothelial dysfunction. 2,3High-sensitivity C-reactive protein (hs-CRP), a marker of systemic inflammation, is associated with increased risk of coronary heart disease. 4 Previously, several studies have shown that CRP levels were noted to be higher in patients with hypertension and increased baseline CRP levels were associated with future development of hypertension in healthy women and men. [5][6][7] Although various studies have examined the association between CRP and LVM, the results obtained were controversial. 8,9 In addition, in patients with newly diagnosed essential hypertension, the relation between CRP levels and LVH and LV diastolic function has not yet been investigated.The aim of this study was to evaluate the relationship between serum hs-CRP levels and LVH, and LV diastolic function in patients with never-treated essential hypertension. MATERIAL AND METHODS Study PopulationThe study population consisted of 95 newly diagnosed essential hypertensive patients without known hypertension and a history of antihypertensive drug treatment according to national healthcare records. Twenty healthy n...

Hypersensitive C-reactive Protein as a Potential Indicator for Predicting Left Ventricular Hypertrophy in Elderly Community-Dwelling Patients with Hypertension

“…While hs-CRP and NLR were independently correlated with LVH, RDW did not show an independent in uence on LVH in our study. These results differ from previous studies [15,24]. One possible explanation is that the previous studies included newly diagnosed or untreated hypertension patients, where the in ammatory effects were not suppressed.…”

“…Salles et al [12] reported that high CRP (≥ 3.7 mg/L) is independently associated with the occurrence of LVH in patients with resistant hypertension, even after adjusting for important confounding factors. Studies conducted by Seyfeli et al [15] and Yu et al [11] consistently demonstrated a signi cant association between serum hs-CRP and left ventricular diastolic function as well as concentric hypertrophy in hypertensive patients. The precise pathophysiological mechanisms underlying these associations are still not fully understood.…”

“…In particular, LVH is strongly associated with in ammation. Previous studies have demonstrated that CRP, NLR, and RDW can increase the risk of LVH in hypertensive patients [11,[13][14][15][23][24]. In our study, we compared the routine indicators of in ammation between the two groups using the health screening program.…”

“…Of these, CRP has been extensively studied and is considered the most representative in ammatory factor. These ndings have been demonstrated in studies conducted on speci c hypertensive populations, such as those with newly diagnosed hypertension, pediatric hypertension, and hypertension combined with systemic diseases [15][16][17]. However, there is a lack of research focusing on the correlation between hs-CRP levels and LVH in elderly hypertensive patients residing in the community.…”

Comprehensive bioinformatics analysis identifies LAPTM5 as a potential blood biomarker for hypertensive patients with left ventricular hypertrophy

“…This has led to accelerate research on the use of circulating biomarkers as diagnostic and prognostic tools for LVH AGING in patients with hypertension, as it is difficult to obtain tissue biopsies. Circulating biomarkers for hypertensive heart disease, including brain natriuretic peptide (BNP), pro-BNP, soluble ST2 (sST2), Creactive protein (CRP), cardiotrophin-1, and the ratio of neutrophil-to-lymphocyte [4][5][6][7] have been extensively investigated. Despite the high clinical and diagnostic value of these biomarkers, more practical biomarkers are required to enhance the early detection and the diagnostic accuracy of cardiac disease.…”