The relationship between HER2/neu expression and drug resistance for non-small cell lung cancer

Blood digital polymerase chain reaction as a potential method to detect human epidermal growth factor receptor 2 amplification in non-small cell lung cancer

“…Previous studies have shown that HER2 gene amplification was present in 10-20% of NSCLC patients (6,7). Notably, HER2 amplification rates have been shown to be associated with the drug resistance in NSCLC (8,9). At present, the clinical detection of HER2 amplification is generally by immunohistochemistry (IHC) or fluorescence in situ hybridization (FISH) (10).…”