The relationship between heart rate variability and time-course of carcinoembryonic antigen in colorectal cancer

Mouton, Charlotte; Ronson, Alain; Razavi, Darius; Delhaye, François; Kupper, Nina; Paesmans, Marianne; Moreau, Michel; Nogaret, Jean-Marie; Hendlisz, Alain; Gidron, Yori

doi:10.1016/j.autneu.2011.10.002

Cited by 63 publications

(73 citation statements)

References 31 publications

(48 reference statements)

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“…Using a cut-off of 20 msec for SDNN (29), a significant interaction was found between SDNN and stage [F(2,41)=15.262; p<0.001] in relation to PSA levels at 6 months. The same significant interaction was observed between the cut-off for RMSSD (also 20 ms) and stage [F(2,37)=13.194; p<0.001] in relation to PSA levels at 6 months.…”

Section: Resultsmentioning

confidence: 99%

“…Such short ECGs have been found to correlate with ECGs of longer durations (5 and 10 min), particularly with respect to RMSSD (33,34), but also for SDNN (24 h) (35). Furthermore, 10 sec SDNN has been shown to predict tumor marker levels in colon cancer (29). For the moderation analyses, a cut-off of 20 msec was used, as in previous studies in cancer (29), to distinguish between patients with high vs. low SDNN and RMSSD.…”

Section: Methodsmentioning

confidence: 99%

“…Most patients were excluded due to the lack of ECG in their medical files. Based on the effect sizes previously observed with smaller samples (27,29), the sample sizes in both PC and NSCLC were expected to be sufficient to detect statistically significant relationships and to explore for moderators.…”

Section: Methodsmentioning

confidence: 99%

“…Furthermore, 10 sec SDNN has been shown to predict tumor marker levels in colon cancer (29). For the moderation analyses, a cut-off of 20 msec was used, as in previous studies in cancer (29), to distinguish between patients with high vs. low SDNN and RMSSD.…”

Section: Methodsmentioning

confidence: 99%

“…These studies also included patients with cardiac diseases or other conditions known to affect HRV. We recently showed that low HRV predicts increases in the colon marker carcinoembryonic antigen (CEA), independent of confounders and excluding cardiac patients (29). However, the sample size of the latter study was also relatively small (N=72), and baseline levels of the tumor marker were not considered.…”

Section: Introductionmentioning

confidence: 99%

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The relationship between vagal nerve activity and clinical outcomes in prostate and non-small cell lung cancer patients

Couck¹,

Brummelen²,

Schallier³

et al. 2013

Oncology Reports

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Abstract. Recent studies suggest that vagal nerve activity, indexed by heart rate variability (HRV), could have a prognostic role in cancer. However, most studies did not control adequately for confounders and included cardiac patients. Furthermore, the validity of this prognostic role needs to be tested in different types of cancer. The present study tested the prognostic role of HRV in prostate cancer (PC) and non-small cell lung cancer (NSCLC) patients, using a historical prospective design. HRV was derived from brief 10 sec ECGs obtained at approximately the time of diagnosis in 113 PC patients and 133 NSCLC patients. Outcomes included prostate-specific antigen (PSA) at 6 and 24 months in PC, and overall survival (OS) (for the full sample) and survival time (for the deceased patients) in NSCLC. Furthermore, the possible mediating role of C-reactive protein (CRP) was tested (in NSCLC), as well as whether age and stage moderated the relationship between HRV and prognosis in both types of cancer. In the PC patients, HRV significantly inversely predicted PSA levels at 6 and 24 months, independent of confounders. Furthermore, this was particularly significant in metastatic PC patients, indicating moderation by stage. In NSCLC patients, HRV did not predict OS and survival time, but it did positively predict survival time in patients under the age of 65, independent of confounders. Additionally, CRP was not found to mediate the relationship between HRV and OS or survival time in NSCLC. The present results partly support previous studies and extend them to two additional common types of cancer, using a more rigorous control over confounders. Together with recent experimental findings, these results propose a modulatory role of vagal nerve activity in cancer. Therefore, routine measurement of HRV in estimating prognosis in cancer may be considered.

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Section: Resultsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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The relationship between vagal nerve activity and clinical outcomes in prostate and non-small cell lung cancer patients

Couck¹,

Brummelen²,

Schallier³

et al. 2013

Oncology Reports

Self Cite

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Putative role of non‐invasive vagus nerve stimulation in cancer pathology and immunotherapy: Can this be a hidden treasure, especially for the elderly?

Abdullahi,

Wong,

2023

Cancer Medicine

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Cancer is globally a disease of significant public health concern owing to its prevalence, and association with morbidity and mortality. Thus, cost‐effective treatments for cancer are important to help reduce its significant morbidity and mortality. However, the current therapeutic options for cancer such as chemotherapy, radiotherapy, and surgery may produce serious adverse events such as nausea, vomiting, fatigue, and peripheral neuropathy, especially in the long term. In addition, these therapeutic options may not be well tolerated by the elderly especially those who are frail. The current article is aimed at discussing an alternative therapeutic option, non‐invasive vagus nerve stimulation (VNS), and the roles it plays in cancer pathology and immunotherapy. The VNS does this by reducing oxidative stress via silent information regulator 1 (SIRT1); inhibiting inflammation via both hypothalamic–pituitary–axis (HPA) and the release of corticosteroid from the adrenal gland, and cholinergic anti‐inflammatory pathway (CAP), and increasing vagal activity which helps in the regulation of cell proliferation, differentiation, apoptosis, and metabolism, and increase chance of survival. Furthermore, it helps with reducing complications due to cancer or its treatments such as postoperative ileus and severity of peripheral neuropathy induced by chemotherapy, and improves cancer‐related fatigue, lymphopenia, and quality of life. These suggest that the importance of non‐invasive VNS in cancer pathology and immunotherapy cannot be overemphasized. Therefore, considering the safety of non‐invasive VNS and its cost‐effectiveness, it is a therapeutic option worth trying for these patients, especially in combination with other therapies.

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Psychosocial Factors and the Prognosis of Cancer

Gidron

2019

Behavioral Medicine

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The relationship between heart rate variability and time-course of carcinoembryonic antigen in colorectal cancer

Abstract: These preliminary results showed that higher HRV predicts lower levels of a tumor marker, one year later, independent of confounders. This supports the hypothesized role of vagal activity in tumor modulation. Replication in larger samples is needed.

Cited by 63 publications

References 31 publications

The relationship between vagal nerve activity and clinical outcomes in prostate and non-small cell lung cancer patients

The relationship between vagal nerve activity and clinical outcomes in prostate and non-small cell lung cancer patients

Putative role of non‐invasive vagus nerve stimulation in cancer pathology and immunotherapy: Can this be a hidden treasure, especially for the elderly?

Psychosocial Factors and the Prognosis of Cancer

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