The relationship between grip strength and muscle mass (MM), inflammatory biomarkers and physical performance in community-dwelling very old persons

Legrand, Delphine; Adriaensen, Wim; Vaes, Bert; Matheï, Catharina; Wallemacq, Pierre; Degryse, Jean-Marie

doi:10.1016/j.archger.2013.06.003

Cited by 78 publications

(71 citation statements)

References 43 publications

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“…However, only those individuals aged 70-79 years who had completed the 7-year follow-up were included. These results could not be confirmed in more representative studies of the elderly (Verghese et al 2011;Brinkley et al 2009), including our findings (Legrand et al 2013). Despite the biological interactions, TNF-α was shown to be less stable than IL-6, and only weak correlations could be found between these markers (Verghese et al 2011) (Pearson r=0.12, p=0.012).…”

Section: Value Of Crp and Other Inflammatory Markerscontrasting

confidence: 84%

Interleukin-6 predicts short-term global functional decline in the oldest old: results from the BELFRAIL study

Adriaensen

Matheï

Vaes

et al. 2014

AGE

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The chronic inflammatory state at old age may contribute to the pathophysiology of or reflect chronic conditions resulting in loss of physical and mental functioning. Therefore, our objective was to examine the predictive value of a large battery of serum inflammatory markers as risk indicators for global functional decline and its specific physical and mental determinants in the oldest old. Global functional decline and specific aspects of physical and mental functional decline were assessed during an average of 1.66 years (±0.21) in a sample of 303 persons aged 80 years or older of the BELFRAIL study. Serum levels of 14 inflammatory proteins, including cytokines, growth factors, and acute phase proteins, were measured at baseline. Almost 20 % of the participants had a significant global functional decline over time. Interleukin (IL)-6 serum levels were uniquely positively associated with global functional decline, even after correcting for multiple confounders (odds ratio 1.51). Odds ratios for the individual aspects (physical dependency, physical performance, cognition, and depression) of functioning were lower, and composite scores of physical or mental decline were not significant. The proportion of global functional decline exhibited a dose-response curve with increasing levels of IL-6. Thus, IL-6 is an independent risk indicator for accelerated global functional decline in the oldest old. Our results suggest that simple serum levels of IL-6 may be very useful in short-term identification or evaluation of global functional status in the oldest old.

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Section: Value Of Crp and Other Inflammatory Markerscontrasting

confidence: 84%

Interleukin-6 predicts short-term global functional decline in the oldest old: results from the BELFRAIL study

Adriaensen

Matheï

Vaes

et al. 2014

AGE

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“…A few considered alternative methods to create a latent variable or inflammatory index from multiple inflammatory biomarkers to account for their interrelationship [18,19]. Only two included adults aged 80 and over, but reported conflicting results [15,18]. Comparison between the studies employing an inflammatory profile approach in relation to muscle strength is difficult because of the differences in biomarker selection, methods used to derive summary measure of inflammation, physical performance tests used, and the population included.…”

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

“…However, the results have been contradictory. In the Health ABC study, TNF-α and CRPrelated components (derived by PCA from 8 inflammatory biomarkers) were inversely associated with GS [19], but higher inflammatory index (a combination of gender-adjusted tertiles of IL-6 and TNF-α) was not associated with worse GS and physical performance in older adults aged ≥80 living in Belgium [18]. Furthermore, little is known about the prospective inflammation-muscle strength relationship in the very old, who are at the highest risk of low muscle strength as well as subclinical inflammation [20].…”

Section: Introductionmentioning

confidence: 99%

“…Both cross-sectional and longitudinal studies have shown the relationship between lower muscle strength and decline with higher plasma concentration of interleukin-6 (IL-6) and tumour necrosis factor alpha (TNF-α) and C-reactive protein (hsCRP) which were analysed either separately [10][11][12][13][14][15], or in combination [9,16], or as a part of summary variable derived statistically to characterise inflammatory profile [17][18][19]. Assessing these biomarkers individually in relation to muscle strength and physical performance decline has been the commonest approach.…”

Section: Introductionmentioning

confidence: 99%

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37grip Strength and Inflammatory Biomarker Profiles in Very Old Adults

et al. 2017

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Background: weak grip strength (GS) and chronic inflammation have been implicated in the aetiology of sarcopenia in older adults. Given the interrelationships between inflammatory biomarkers, a summary variable may provide better insight into the relationship between inflammation and muscle strength. This approach has not been investigated in very old adults (aged ≥85) who are at highest risk of muscle weakness. Methods: we used mixed models to explore the prospective association between GS over 5 years in 845 participants in the Newcastle 85+ Study, and inflammatory components identified by principal component analysis (PCA). Cut-offs of ≤27 kg (men) and ≤16 (women) were used to define sub-cohorts with weak and normal GS at each assessment. Results: PCA identified three components, which explained 70% of the total variance in seven baseline biomarkers. Basal interleukin-6 (IL-6) and tumour necrosis factor (TNF-α) had the highest loadings on Component 1; stimulated IL-6 and TNF-α and homocysteine the highest on Component 2; high-sensitivity C-reactive protein (hsCRP) loaded positively and albumin negatively to Component 3. In adjusted mixed models, only Component 3 was associated with GS. One SD increase of Component 3 was associated with a 0.41 kg lower GS initially (P = 0.03) in all participants, but not with GS decline over time. Similar conclusions held for those in the weak and normal GS sub-cohorts.

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Association of Body Composition, Physical Functioning, and Protein Intake in Adult Patients With Mitochondrial Diseases

Zweers

Bordier

Hulst

et al. 2020

J Parenter Enteral Nutr

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Background Whether decreased physical functioning of patients with mitochondrial disease (MD) is related to altered body composition or low protein intake needs clarification at the background of the nutrition state. Methods In this 2‐site cross‐sectional study, MD patients were age‐, body mass index (BMI)–, and gender‐matched to controls. Body composition was assessed by dual‐energy x‐ray absorptiometry. Physical functioning was measured by handgrip strength, 6‐minute walking test, 30‐second sit‐to‐stand test (30SCT), and 6‐minute mastication test. Total daily protein intake was calculated by 3‐day food records. Malnutrition was assessed by Patient‐Generated Subjective Global Assessment and the Global Leadership Initiative on Malnutrition (GLIM) criteria and sarcopenia by the 2018 consensus. Data were analyzed using independent samples t‐tests, Fisher exact test, and Spearman and Pearson correlation coefficients. Results Thirty‐seven MD patients (42 ± 12 years, BMI: 23 ± 4 kg/m2, 59% females) and 37 matched controls were included. Handgrip strength was moderate, inversely related to fat mass index in both MD patients and controls, whereas it correlated with fat‐free mass index in controls solely. Protein intake was associated with muscle strength (handgrip strength and 30SCT) in MD patients but not in controls. Twenty‐seven MD patients (73%) were malnourished, and 5 (14%) were classified as sarcopenic. Conclusions Muscle strength is related to body composition and protein intake in MD patients. This, in combination with the high incidence of both malnutrition and sarcopenia, warrants individual nutrition assessment in MD patients.

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The relationship between grip strength and muscle mass (MM), inflammatory biomarkers and physical performance in community-dwelling very old persons

Cited by 78 publications

References 43 publications

Interleukin-6 predicts short-term global functional decline in the oldest old: results from the BELFRAIL study

Interleukin-6 predicts short-term global functional decline in the oldest old: results from the BELFRAIL study

37grip Strength and Inflammatory Biomarker Profiles in Very Old Adults

Association of Body Composition, Physical Functioning, and Protein Intake in Adult Patients With Mitochondrial Diseases

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