The Relationship Between Glycemic Response and the Incidence of OCD in Thoroughbred Weanlings: A Field Study

Pagan, Joe D.; Geor, R. J.; Caddel, Steve; Pryor, Peter B.; Hoekstra, Kari E.

doi:10.7313/upo9781908062161.037

Cited by 20 publications

(24 citation statements)

References 7 publications

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“…Research by Glade et al (1984) and Ralston (1995) suggest that foals that experience a continued exposure to high levels of circulating glucose or insulin in response to a high-grain meal may be predisposed to development of OCD. Research suggests a link between glycaemic index and the incidence of OCD in growing horses (Pagan et al 2001;Pagan 2003) (Figure 3.4). This research suggests that reducing the level of starch, slowing feed intake and lowering the glycaemic index of the feed may help reduce the incidence of OCD in growing horses.…”

Section: Endocrine Factorsmentioning

confidence: 99%

Applied Animal Nutrition

Fleeman¹,

Owens²

2007

Animal Physiotherapy

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Section: Endocrine Factorsmentioning

confidence: 99%

Applied Animal Nutrition

Fleeman¹,

Owens²

2007

Animal Physiotherapy

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“…The aetiology of diabetes is a continuum, with abnormal OGTT preceded by an abnormal insulin response (Barbieri et al 2001). Altered glucose metabolism and/or hyperinsulinaemia has been associated with an increased risk of laminitis (Pass et al 1998), exertional rhabdomyolysis (Valentine et al 1998), osteochondritis dissecan (Ralston 1995;Pagan et al 2001), colic and other serious metabolic problems (Cohen et al 1999). It has yet to be determined whether it is hyperinsulinaemia itself or insulin resistance that is ultimately the cause of these conditions; however, these published data underscore the potential danger of insulin resistance and/or hyperinsulinaemia.…”

Section: Oral Glucose Tolerance Testmentioning

confidence: 99%

Effect of training on age‐related changes in plasma insulin and glucose

Malinowski

Betros

Flora

et al. 2002

Equine Veterinary Journal

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SummaryThe purpose of the study was to determine whether 12 weeks of exercise training would affect plasma glucose and plasma insulin concentrations in young and older Standardbred mares. Eighteen healthy, unfit mares representing 3 age groups were used: young (Y = 6.8 ± 0.4 years; n = 6), middleaged (MA = 15.2 ± 0.4; n = 6), and old (O = 27.0 ± 0.2; n = 6). Pre-and post-training incremental exercise tests (GXT) were performed to measure plasma glucose and insulin concentration from immediately after, until 120 min postexercise. Training consisted of exercise 3 days/week (weeks 1-8) and 4 days/week (weeks 9-12) at a submaximal intensity (~60% of pretraining HR max ) for~30 min/day. Old mares had lower levels of glucose after the GXT when compared to Y and MA mares (P<0.05). There was also a timeby-age interaction (P = 0.003) in that, at 120 min post-GXT, glucose levels had not returned to pre-exercise values. Plasma glucose concentrations, in response to acute exercise, were not altered by training for any age group (P>0.05). Prior to exercise training, O mares had higher plasma insulin compared to Y and MA mares at 120 min postexercise (P<0.05), and insulin was also elevated in O mares compared to all other time points at 120 min post-GXT (P<0.05). Training resulted in increased plasma insulin concentrations at 120 min post-GXT in all age groups (P<0.05). In conclusion, age affected glucose and insulin responses to acute exercise prior to and after 12 weeks of exercise training. With regards to insulin, 12 weeks of exercise training resulted in a postexercise rebound hyperinsulinaemia, which may be related to an increased need for glycogen repletion in the muscle. These factors are important in considering the ability of an older horse to tolerate exercise.

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“…Diets differing in carbohydrate content could influence OC through metabolic parameters such as glucose, insulin, and insulinlike growth factor-1 (IGF-1) as shown in horses (Ralston, 1996;Sloet van Oldruitenborgh-Oosterbaan et al, 1999;Pagan, 2001). Insulin and Contents lists available at ScienceDirect journal homepage: www.elsevier.com/locate/livsci IGF-1 affect survival and proliferation of chondrocytes (Hunziker et al, 1994;Henson et al, 1997) and are involved in growth (Balage et al, 2001;Laron, 2001).…”

Section: Introductionmentioning

confidence: 99%